EC Number   |
General Information |
Reference |
|---|
   3.4.21.B25 | evolution |
the enzyme belongs to the subtilisin-like proprotein convertase (SPC) family |
731787 |
| 3.4.21.B25 | malfunction |
enzyme PACE4 knockdown causes blockage of chondrogenic differentiation through downregulation of proBMP6 activation |
731787 |
| 3.4.21.B25 | malfunction |
silencing of PACE4 causes the suppression of branching morphogenesis and aquaporin 5 expression in rat embryonic submandibular gland rudiments culture system |
718024 |
| 3.4.21.B25 | malfunction |
the expression of myosin light chain mRNA transcript is markedly reduced in PACE4 knockdown cells |
708949 |
| 3.4.21.B25 | malfunction |
the PACE4 gene-knockdown cells show a drastic decrease in mineralization even in the presence of any estrogen stimulus |
732215 |
| 3.4.21.B25 | malfunction |
when the PACE4 gene is silenced by small interfering RNA the knockdown of human breast cancer MDA-MB-231 cells shows significantly reduced proliferation, migration and invasion rates |
754757 |
| 3.4.21.B25 | metabolism |
insulin receptor requires the proteolytic cleavage of its proform by intra-Golgi furin-like activity. In mammalian cells, insulin receptor is expressed as two isoforms B and A that are responsible for insulin action, but only isozyme A transmits the growth-promoting and mitogenic effects of insulin-like growth factor 2. The two insulin receptor isoforms are similarly cleaved by furin, but when this furin-dependent maturation is inefficient, insulin receptor proforms move to the cell surface where the proprotein convertase PACE4 selectively supports insulin receptor B maturation |
732179 |
| 3.4.21.B25 | physiological function |
morula compaction and inner cell mass formation depend on PC7 and the related proteases Furin and Pace4. These proteases jointly regulate cell-cell adhesion mediated by E-cadherin processing during blastocyst formation |
754231 |
| 3.4.21.B25 | physiological function |
Pace4 activates Nodal in the epiblast to maintain pluripotency. Secreted Pace4 stimulates mesoderm and endoderm formation. Expression of Pace4 in the extraembryonic ectoderm suppresses neural differentiation |
717637 |
| 3.4.21.B25 | physiological function |
PACE4 plays a critical role in myogenic differentiation of C2C12 cells through its association with the insulin-like growth factor-II pathway |
708949 |
