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Literature summary for 3.4.21.B25 extracted from
- Physiological role of a subtilisin - Like proprotein convertase, PACE4, in submandibular gland development (2010), J. Oral Biosci., 52, 81-93.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| decanoyl-L-Arg-L-Val-L-Lys-chloromethylketone | potent inhibitor | Rattus norvegicus |  |
| additional information | not inhibited by leupeptin and soybean trypsin inhibitor | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pro-branching morphogenesis protein 2 + H2O | Rattus norvegicus | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| submandibular gland | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pro-branching morphogenesis protein 2 + H2O | - |
Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PACE4 | - |
Rattus norvegicus |
| SPC4 | - |
Rattus norvegicus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | silencing of PACE4 causes the suppression of branching morphogenesis and aquaporin 5 expression in rat embryonic submandibular gland rudiments culture system | Rattus norvegicus |
| physiological function | PACE4 plays an important role in submandibular gland development | Rattus norvegicus |
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Release 2023.1 (January 2023)
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