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Literature summary for 3.4.21.B25 extracted from

  • Mesnard, D.; Donnison, M.; Fuerer, C.; Pfeffer, P.L.; Constam, D.B.
    The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities (2011), Genes Dev., 25, 1871-1880.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.B25

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CLIP protein + H2O Mus musculus
-
 ?
-
 ?
pro-Nodal + H2O Mus musculus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Mus musculus
-
epiblast
-
 Mus musculus
-
epithelial cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CLIP protein + H2O
-
 Mus musculus ?
-
 ?
pro-Nodal + H2O
-
 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
PACE4
-
 Mus musculus

General Information

General Information Comment Organism
physiological function Pace4 activates Nodal in the epiblast to maintain pluripotency. Secreted Pace4 stimulates mesoderm and endoderm formation. Expression of Pace4 in the extraembryonic ectoderm suppresses neural differentiation Mus musculus