Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha1-antitrypsin | - |
Mus musculus | |
decanoyl-Arg-Val-Lys-Arg-chloromethylketone | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
proform bone morphogenetic protein 6 + H2O | Mus musculus | BMP6, the substrate is exclusively found in hypertrophic chondrocytes | mature bone morphogenetic protein 6 + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
ATDC-5 cell | an embryonal carcinoma-derived clonal cell line | Mus musculus | - |
chondrocyte | hypertrophic chondrocyte | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
proform bone morphogenetic protein 6 + H2O | BMP6, the substrate is exclusively found in hypertrophic chondrocytes | Mus musculus | mature bone morphogenetic protein 6 + ? | - |
? | |
proform bone morphogenetic protein 6 + H2O | BMP6, recombinantly expressed FLAG-tagged human substrate protein. The enzyme recognizes the sequence RTTR(371-374) of human BMP6 and cleaves proBMP6 at its C-terminus | Mus musculus | mature bone morphogenetic protein 6 + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PACE4 | - |
Mus musculus |
paired basic amino acid-cleaving enzyme 4 | - |
Mus musculus |
SPC4 | - |
Mus musculus |
subtilisin-like proprotein convertase 4 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | enzyme PACE4 mRNA levels increase markedly during chondrogenic differentiation of ATDC-5 cells, overview | up |
General Information | Comment | Organism |
---|---|---|
evolution | the enzyme belongs to the subtilisin-like proprotein convertase (SPC) family | Mus musculus |
malfunction | enzyme PACE4 knockdown causes blockage of chondrogenic differentiation through downregulation of proBMP6 activation | Mus musculus |
physiological function | the enzyme is required for chondrogenic differentiation, e.g. for differentiation of ATDC-5 cells into type II collagen-expressing chondrocytes, type X collagen-expressing hypertrophic chondrocytes, and mineralizing chondrocytes | Mus musculus |