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anthrax toxin PA + H2O
?
-
contains the sequence RKKR at the cleavage site
-
?
anthrax toxin protective antigen + H2O
?
-
-
-
?
benzyloxycarbonyl-REKR-7-amido-4-trifluoromethylcoumarin + H2O
?
-
-
-
?
BMP2 proprotein + H2O
BMP2 + ?
-
-
-
-
?
CLIP protein + H2O
?
-
-
-
-
?
dipththeria toxin + H2O
?
-
-
-
?
envelope glycoprotein gp160
?
well activated by PaCE4
-
-
?
human immunodeficiency virus type 1 Vpr + H2O
?
undergoes proteolytic processing at a very well conserved proprotein convertase cleavage site, R85QRR88-/-, proprotein convertases PC5 and PACE4 can efficiently process extracellular Vpr
-
-
?
insulin proreceptor + H2O
?
-
-
-
?
insulin receptor isoform B zymogen + H2O
mature insulin receptor isoform B + ?
L-pyroglutamyl-Arg-Thr-Lys-Arg-4-methylcoumaryl 7-amide + H2O
?
-
-
-
?
L-pyroglutamyl-RTKR-4-methylcoumarin 7-amide + H2O
?
-
-
-
?
low density lipoprotein receptor-elated protein + H2O
?
-
-
-
?
pGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin + H2O
?
-
-
-
?
pGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin + H2O
pGlu-Arg-Thr-Lys-Arg + 7-amino-4-methylcoumarin
-
-
-
?
pro-beta site APP cleaving enzyme + H2O
beta site APP cleaving enzyme + ?
-
i.e. BACE, weak substrate
-
?
pro-branching morphogenesis protein 2 + H2O
?
-
-
-
-
?
pro-complement C3 + H2O
?
-
-
-
?
pro-Nodal + H2O
?
-
-
-
-
?
pro7B2 + H2O
7B2 + ?
-
PACE4-A
-
?
proADAMTS-4 + H2O
?
recombinant PACE4 activates proADAMTS-4 by removal of the prodomain
-
-
?
proADAMTS-5 + H2O
?
recombinant PACE4 activates proADAMTS-5 by removal of the prodomain
-
-
?
proalbumin + H2O
albumin + ?
-
-
-
?
proform bone morphogenetic protein 6 + H2O
mature bone morphogenetic protein 6 + ?
prosomatostatin + H2O
somatostatin-14 + somatostatin-28
-
enzyme cleaves at a dibasic Arg-Lys site
-
?
Pyr-Arg-Thr-Lys-Arg-4-methylcoumarin-7-amide + H2O
Pyr-Arg-Thr-Lys-Arg + 7-amino-4-methylcoumarin
-
-
-
ir
tert-butyloxycarbonyl-Arg-Val-Arg-Arg-4-methylcoumarin 7-amide + H2O
tert-butyloxycarbonyl-Arg-Val-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
Vg1 + H2O
?
Vg1 in a TgF beta-related growth factor localized to vegetal blastomers in Xenopus embryos
-
-
?
von Willebrand factor precursor + H2O
mature von Willebrand factor + ?
Xnr1 + H2O
?
i.e. Nodal-related protein 1
-
-
?
Xnr2 + H2O
?
i.e. Nodal-related protein 2
-
-
?
Xnr3 + H2O
?
i.e. Nodal-related protein 3
-
-
?
additional information
?
-
insulin receptor isoform B zymogen + H2O
mature insulin receptor isoform B + ?
-
-
-
?
insulin receptor isoform B zymogen + H2O
mature insulin receptor isoform B + ?
maturation
-
-
?
preprohepcidin + H2O
?
key role of the convertases furin, PACE4, PC5 and/or PC7 in the generation and secretion of active hepcidin
-
-
?
preprohepcidin + H2O
?
key role of the convertases furin, PACE4, PC5 and/or PC7 in the generation and secretion of active hepcidin. PC7 processes this peptide at the cleavage site of preprohepcidin PMFQRRRRR-/-, resulting in a major 1305 Da N-terminal product. Two minor products with masses of 149 Da and 993 Da are also detected which correspond to the loss of one (PMFQRRRR) or two (PMFQRRR) C-terminal Arg, respectively
-
-
?
proform bone morphogenetic protein 6 + H2O
mature bone morphogenetic protein 6 + ?
-
BMP6, the substrate is exclusively found in hypertrophic chondrocytes
-
-
?
proform bone morphogenetic protein 6 + H2O
mature bone morphogenetic protein 6 + ?
-
BMP6, recombinantly expressed FLAG-tagged human substrate protein. The enzyme recognizes the sequence RTTR(371-374) of human BMP6 and cleaves proBMP6 at its C-terminus
-
-
?
von Willebrand factor precursor + H2O
mature von Willebrand factor + ?
-
-
-
?
von Willebrand factor precursor + H2O
mature von Willebrand factor + ?
-
-
-
?
von Willebrand factor precursor + H2O
mature von Willebrand factor + ?
-
-
?
von Willebrand factor precursor + H2O
mature von Willebrand factor + ?
-
cleavage requires both the P4 arginine and the P2 lysine
-
?
additional information
?
-
-
enzyme cleaves at sites with paired basic amino acid residues
-
?
additional information
?
-
-
no substrate: profactor IX
-
?
additional information
?
-
-
no substrate: Pseudomonas exotoxin A
-
?
additional information
?
-
-
PACE4-CS recognizes the motifs X-Ala and X-Pro
-
?
additional information
?
-
-
enzyme binds tightly to heparin and anchors heparan sulfate proteoglycans at the extracellular matrix, role in spatiotemporal regulation of TGFbeta-related factors' biological activity
-
?
additional information
?
-
substrate cleavage analysis
-
-
?
additional information
?
-
-
substrate cleavage analysis
-
-
?
additional information
?
-
no activity with insulin receptor isoform A zymogen
-
-
?
additional information
?
-
-
enzyme requires basic residues in the -1, -2 and -4 position of the substrate sequence, can recognize RAAR and, to a much lesser extent, KR and RR
-
?
additional information
?
-
-
role in proteolytic activation of anthrax toxin PA
-
?
additional information
?
-
does not cleave proopiomelanocortin, proglucagon, prosomatostatin and secretogranin in neuroendocrine cells
-
-
?
additional information
?
-
-
the main substrates for PACE4 are membrane type matrix metalloproteinases
-
-
?
additional information
?
-
PACE4 is identified as a proprotein convertase responsible for activation of aggrecanases in osteoarthritic and cytokine-stimulated cartilage
-
-
?
additional information
?
-
PACE4 regulates the submandibular gland development via the activation of some growth/differentiation factors
-
-
?
additional information
?
-
no cleavage of Xnr5, Derrière or ActivinB pro-proteins
-
-
?
additional information
?
-
no cleavage of Xnr5, Derrière or ActivinB pro-proteins
-
-
?
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2-(11-hydroxy-3-oxo-3H-dibenzo[c,h]xanthen-7-yl)benzoic acid
-
3,3',3'',3'''-(benzene-1,4-diyldimethanetriyl)tetrakis(4-hydroxy-2H-chromen-2-one)
-
3,3'-(1,3-benzodioxol-5-ylmethanediyl)bis(4-hydroxy-2H-chromen-2-one)
-
3,3'-(2,3-dihydro-1H-inden-5-ylmethanediyl)bis(4-hydroxy-2H-chromen-2-one)
-
A23187
-
if reticulocalbin-3 binds to proPACE4 transiently during its biosynthesis, this Ca2+-specific ionophore can block the maturation of proPACE4 to PACE4, accumulation of the proPaCE4-recticulocalbin-3 complex in the cells
Ac-(D)LLLLRVK-2,3-dehydroagmatine
-
Ac-(D)LLLLRVK-4-amidinobenzylamide
-
Ac-LLLLR-((2S)-amino-3S-guanidinobutyryl)-KR-NH2
Ki(furin)/Ki(PACE4): 40
Ac-LLLLR-((2S,3R)-diaminobutyryl)-KR-NH2
Ki(furin)/Ki(PACE4): 9
Ac-LLLLR-((2S,3S)-diaminobutyryl)-KR-NH2
Ki(furin)/Ki(PACE4): 18
Ac-LLLLR-(2,3-diaminobutyryl)-KR-NH2
Ki(furin)/Ki(PACE4): 12
Ac-LLLLR-(2,3-diaminopropionyl)-KR-NH2
Ki(furin)/Ki(PACE4): 51
Ac-LLLLR-(2-amino-3-guanidinopropionyl)-KR-NH2
Ki(furin)/Ki(PACE4): 19
Ac-LLLLR-(2-amino-4-guanidinobutyryl)-KR-NH2
Ki(furin)/Ki(PACE4): 10
Ac-LLLLR-Orn-KR-NH2
Ki(furin)/Ki(PACE4): 21
Ac-LLLLRAKR-NH2
Ki(furin)/Ki(PACE4): 7
Ac-LLLLRKKR-NH2
Ki(furin)/Ki(PACE4): 18
Ac-LLLLRRKR-NH2
Ki(furin)/Ki(PACE4): 12
Ac-LLLLRVK-2,3-dehydroagmatine
-
Ac-LLLLRVK-4-amidinobenzylamide
-
Ac-[C8](D)LLLLRVK-4-amidinobenzylamide
-
Ac-[C8]LLLLRVK-4-amidinobenzylamide
-
Ac-[PEG2](D)LLLLRVK-4-amidinobenzylamide
-
Ac-[PEG8](D)LLLLRVK-2,3-dehydroagmatine
-
Ac-[PEG8](D)LLLLRVK-4-amidinobenzylamide
-
Ac-[PEG8](D)LLLLRVKR-NH2
-
Ac-[PEG8]LLLLRVK-2,3-dehydroagmatine
-
Ac-[PEG8]LLLLRVK-4-amidinobenzylamide
-
alpha1-antitrypsin variant AVRR
-
50% inhibition above 0.002 mM
-
alpha1-antitrypsin variant PDX
-
50% inhibition above 0.00002 mM, forms a complex with the enzyme
-
alpha1-antitrypsin variant Portland
-
contains a minimal consensus sequence (Arg-X-X-Arg) for efficient cleavage by furin in its reactive site loop
-
alpha1-antitrypsin variant RRRRSA
-
rat alpha-antitrypsin showing substitution of Arg-Arg-Arg-Arg for Ala-Val-Pro-Met352 at P4-P1 and Ala for Leu354 at P2'
-
alpha1-antitrypsin variant RRRRSL
-
rat alpha-antitrypsin showing substitution of Arg-Arg-Arg-Arg for Ala-Val-Pro-Met352 at P4-P1
-
alpha1-antitrypsin variant RVRR
-
antisense oligo 5
depletes XPACE4 to 5-10% of control levels; depletes XPACE4 to 5-10% of control levels
Ca2+
-
Ca2+ ionophore inhibits protein maturation
carboxyterminal sequence of PACE4
-
inhibits autocatalytic processing
-
decanoyl-Arg-Val-Lys-Arg-chloromethylketone
decanoyl-L-Arg-L-Val-L-Lys-chloromethylketone
-
potent inhibitor
decanoyl-L-Arg-L-Val-L-Lys-L-Arg-chloromethylketone
-
potent inhibitor
decanoyl-RVKR-chloromethyl ketone
-
H2N-[C8](D)LLLLRVK-2,3-dehydroagmatine
-
H2N-[C8](D)LLLLRVKR-NH2
-
H2N-[C8]LLLLRVK-2,3-dehydroagmatine
-
H2N-[C8]LLLLRVK-4-amidinobenzylamide
-
HgCl2
-
99% inhibition at 1 mM
L-Arg-L-Tyr-L-Lys-L-Arg-L-Thr
-
peptide inhibitor of PACE4
leupeptin
-
94% inhibition at 1 mM
phenylacetyl-Arg-Val-Arg-4-amidinobenzylamide
-
-
reticulocalbin-1
-
reduces efficiency of PACE4 secretion by 21%
-
ZnCl2
-
100% inhibition at 2 mM
[C8](D)LLLLRVK-2,3-dehydroagmatine
-
[C8](D)LLLLRVK-4-amidinobenzylamide
-
[C8]LLLLRVK-2,3-dehydroagmatine
-
[C8]LLLLRVK-4-amidinobenzylamide
-
Ac-LLLLRVKR-NH2
-
Ac-LLLLRVKR-NH2
Ki(furin)/Ki(PACE4): 20
alpha1-antitrypsin variant RVRR
-
50% inhibition at 0.000005 mM, forms a complex with the enzyme
-
alpha1-antitrypsin variant RVRR
-
-
-
decanoyl-Arg-Val-Lys-Arg-chloromethylketone
-
decanoyl-Arg-Val-Lys-Arg-chloromethylketone
-
-
decanoyl-Arg-Val-Lys-Arg-chloromethylketone
-
100% inhibition at 0.01 mM
EDTA
-
85% inhibition at 20 mM
EDTA
-
78% inhibition at 10 mM
EGTA
-
inhibits at 0.5-2 mM
EGTA
-
71% inhibition at 10 mM
additional information
-
no inhibitor: alpha1-antitrypsin
-
additional information
-
not inhibited by alpha1-antitrypsin variant AVRR
-
additional information
-
alpha1-proteinase inhibitor-Portland and alpha1-proteinase inhibitor-Pittsburgh have little effect on PACE4 activity
-
additional information
-
not inhibited by leupeptin and soybean trypsin inhibitor
-
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0.04 - 0.21
Ac-(D)LLLLRVK-2,3-dehydroagmatine
0.025 - 0.04
Ac-(D)LLLLRVK-4-amidinobenzylamide
0.07 - 0.15
Ac-(D)LLLLRVKR-NH2
0.07 - 0.09
Ac-LLLLRVK-2,3-dehydroagmatine
0.025 - 0.04
Ac-LLLLRVK-4-amidinobenzylamide
0.1 - 0.18
Ac-LLLLRVKR-NH2
0.16
Ac-[C8](D)LLLLRVKR-NH2
Homo sapiens
cell survival assay in DU145 cells, pH 7.5, 37°C
0.04
Ac-[C8]LLLLRVK-4-amidinobenzylamide
0.08
Ac-[C8]LLLLRVKR-NH2
Homo sapiens
cell survival assay in DU145 cells, pH 7.5, 37°C
0.07
Ac-[PEG8](D)LLLLRVK-2,3-dehydroagmatine
Homo sapiens
cell survival assay in DU145 cells, pH 7.5, 37°C
0.11 - 0.15
Ac-[PEG8](D)LLLLRVKR-NH2
0.06 - 0.09
H2N-[C8](D)LLLLRVK-2,3-dehydroagmatine
0.09
H2N-[C8](D)LLLLRVKR-NH2
Homo sapiens
cell survival assay in DU145 cells, pH 7.5, 37°C
0.04 - 0.13
H2N-[C8]LLLLRVK-2,3-dehydroagmatine
0.046 - 0.047
H2N-[C8]LLLLRVK-4-amidinobenzylamide
0.015
H2N-[C8]LLLLRVKR-NH2
Homo sapiens
cell survival assay in DU145 cells, pH 7.5, 37°C
0.002
L-Arg-L-Tyr-L-Lys-L-Arg-L-Thr
Rattus norvegicus
-
-
0.013 - 0.03
[C8]LLLLRVK-2,3-dehydroagmatine
0.04
Ac-(D)LLLLRVK-2,3-dehydroagmatine
Homo sapiens
cell survival assay in DU145 cells, pH 7.5, 37°C
0.21
Ac-(D)LLLLRVK-2,3-dehydroagmatine
Homo sapiens
cell survival assay in LNCap cells, pH 7.5, 37°C
0.025
Ac-(D)LLLLRVK-4-amidinobenzylamide
Homo sapiens
cell survival assay in DU145 cells, pH 7.5, 37°C
0.04
Ac-(D)LLLLRVK-4-amidinobenzylamide
Homo sapiens
cell survival assay in LNCap cells, pH 7.5, 37°C
0.07
Ac-(D)LLLLRVKR-NH2
Homo sapiens
cell survival assay in DU145 cells, pH 7.5, 37°C
0.15
Ac-(D)LLLLRVKR-NH2
Homo sapiens
cell survival assay in LNCap cells, pH 7.5, 37°C
0.07
Ac-LLLLRVK-2,3-dehydroagmatine
Homo sapiens
cell survival assay in LNCap cells, pH 7.5, 37°C
0.09
Ac-LLLLRVK-2,3-dehydroagmatine
Homo sapiens
cell survival assay in DU145 cells, pH 7.5, 37°C
0.025
Ac-LLLLRVK-4-amidinobenzylamide
Homo sapiens
cell survival assay in DU145 cells, pH 7.5, 37°C
0.04
Ac-LLLLRVK-4-amidinobenzylamide
Homo sapiens
cell survival assay in LNCap cells, pH 7.5, 37°C
0.1
Ac-LLLLRVKR-NH2
Homo sapiens
cell survival assay in DU145 cells, pH 7.5, 37°C
0.18
Ac-LLLLRVKR-NH2
Homo sapiens
cell survival assay in LNCap cells, pH 7.5, 37°C
0.04
Ac-[C8]LLLLRVK-4-amidinobenzylamide
Homo sapiens
cell survival assay in DU145 cells, pH 7.5, 37°C
0.04
Ac-[C8]LLLLRVK-4-amidinobenzylamide
Homo sapiens
cell survival assay in LNCap cells, pH 7.5, 37°C
0.11
Ac-[PEG8](D)LLLLRVKR-NH2
Homo sapiens
cell survival assay in DU145 cells, pH 7.5, 37°C
0.15
Ac-[PEG8](D)LLLLRVKR-NH2
Homo sapiens
cell survival assay in LNCap cells, pH 7.5, 37°C
0.06
H2N-[C8](D)LLLLRVK-2,3-dehydroagmatine
Homo sapiens
cell survival assay in DU145 cells, pH 7.5, 37°C
0.09
H2N-[C8](D)LLLLRVK-2,3-dehydroagmatine
Homo sapiens
cell survival assay in LNCap cells, pH 7.5, 37°C
0.04
H2N-[C8]LLLLRVK-2,3-dehydroagmatine
Homo sapiens
cell survival assay in DU145 cells, pH 7.5, 37°C
0.13
H2N-[C8]LLLLRVK-2,3-dehydroagmatine
Homo sapiens
cell survival assay in LNCap cells, pH 7.5, 37°C
0.046
H2N-[C8]LLLLRVK-4-amidinobenzylamide
Homo sapiens
cell survival assay in LNCap cells, pH 7.5, 37°C
0.047
H2N-[C8]LLLLRVK-4-amidinobenzylamide
Homo sapiens
cell survival assay in DU145 cells, pH 7.5, 37°C
0.013
[C8]LLLLRVK-2,3-dehydroagmatine
Homo sapiens
cell survival assay in DU145 cells, pH 7.5, 37°C
0.03
[C8]LLLLRVK-2,3-dehydroagmatine
Homo sapiens
cell survival assay in LNCap cells, pH 7.5, 37°C
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Taniguchi, T.; Kuroda, R.; Sakurai, K.; Nagahama, M.; Wada, I.; Tsuji, A.; Matsuda, Y.
A critical role for the carboxy terminal region of the proprotein convertase, PACE4A, in the regulation of its autocatalytic activation coupled with secretion
Biochem. Biophys. Res. Commun.
290
878-884
2002
Homo sapiens
brenda
Mains, R.E.; Berard, C.A.; Denault, J.B.; Zhou, A.; Johnson, R.C.; Leduc, R.
PACE4: a subtilisin-like endoprotease with unique properties
Biochem. J.
321
587-593
1997
Rattus norvegicus
-
brenda
Sucic, J.F.; Moehring, J.M.; Inocencio, N.M.; Luchini, J.W.; Moehring, T.J.
Endoprotease PACE4 is Ca2+-dependent and temperature-sensitive and can partly rescue the phenotype of a furin-deficient cell strain
Biochem. J.
339
639-647
1999
Homo sapiens
brenda
Rehemtulla, A.; Barr, P.J.; Rhodes, C.J.; Kaufman, R.J.
PACE4 is a member of the mammalian propeptidase family that has overlapping but not identical substrate specificity to PACE
Biochemistry
32
11586-11590
1993
Homo sapiens
brenda
Tsuji, A.; Sakurai, K.; Kiyokage, E.; Yamazaki, T.; Koide, S.; Toida, K.; Ishimura, K.; Matsuda, Y.
Secretory proprotein convertases PACE4 and PC6A are heparin-binding proteins which are localized in the extracellular matrix. Potential role of PACE4 in the activation of proproteins in the extracellular matrix
Biochim. Biophys. Acta
1645
95-104
2003
Homo sapiens
brenda
Johnson, R.C.; Darlington, D.N.; Hand, T.A.; Bloomquist, B.T.; Mains, R.E.
PACE4: a subtilisin-like endoprotease prevalent in the anterior pituitary and regulated by thyroid status
Endocrinology
135
1178-1185
1994
Rattus norvegicus (Q63415), Rattus norvegicus
brenda
Pinnix, I.; Council, J.E.; Roseberry, B.; Onstead, L.; Mallender, W.; Sucic, J.; Sambamurti, K.
Convertases other than furin cleave beta-secretase to its mature form
FASEB J.
15
1810-1812
2001
Homo sapiens
brenda
Creemers, J.W.; Groot Kormelink, P.J.; Roebroek, A.J.; Nakayama, K.; Van de Ven, W.J.
Proprotein processing activity and cleavage site selectivity of the Kex2-like endoprotease PACE4
FEBS Lett.
336
65-69
1993
Homo sapiens
brenda
Brakch, N.; Galanopoulou, A.S.; Patel, Y.C.; Boileau, G.; Seidah, N.G.
Comparative proteolytic processing of rat prosomatostatin by the convertases PC1, PC2, furin, PACE4 and PC5 in constitutive and regulated secretory pathways
FEBS Lett.
362
143-146
1995
Mammalia
brenda
Zhong, M.; Benjannet, S.; Lazure, C.; Munzer, S.; Seidah, N.G.
Functional analysis of human PACE4-A and PACE4-C isoforms: identification of a new PACE4-CS isoform
FEBS Lett.
396
31-36
1996
Homo sapiens
brenda
Nagahama, M.; Taniguchi, T.; Hashimoto, E.; Imamaki, A.; Mori, K.; Tsuji, A.; Matsuda, Y.
Biosynthetic processing and quaternary interactions of proprotein convertase SPC4 (PACE4)
FEBS Lett.
434
155-159
1998
Homo sapiens
brenda
Gordon, V.M.; Rehemtulla, A.; Leppla, S.H.
A role for PACE4 in the proteolytic activation of anthrax toxin protective antigen
Infect. Immun.
65
3370-3375
1997
Mammalia
brenda
Mori, K.; Kii, S.; Tsuji, A.; Nagahama, M.; Imamaki, A.; Hayashi, K.; Akamatsu, T.; Nagamune, H.; Matsuda, Y.
A novel human PACE4 isoform, PACE4E is an active processing protease containing a hydrophobic cluster at the carboxy terminus
J. Biochem.
121
941-948
1997
Homo sapiens (P29122), Homo sapiens
brenda
Mori, K.; Imamaki, A.; Nagata, K.; Yonetomi, Y.; Kiyokage-Yoshimoto, R.; Martin, T.J.; Gillespie, M.T.; Nagahama, M.; Tsuji, A.; Matsuda, Y.
Subtilisin-like proprotein convertases, PACE4 and PC8, as well as furin, are endogenous proalbumin convertases in HepG2 cells
J. Biochem.
125
627-633
1999
Homo sapiens
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Tsuji, A.; Ikoma, T.; Hashimoto, E.; Matsuda, Y.
Development of selectivity of alpha1-antitrypsin variant by mutagenesis in its reactive site loop against proprotein convertase. A crucial role of the P4 arginine in PACE4 inhibition
Protein Eng.
15
123-130
2002
Homo sapiens
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Tsuji, A.; Kikuchi, Y.; Sato, Y.; Koide, S.; Yuasa, K.; Nagahama, M.; Matsuda, Y.
A proteomic approach reveals transient association of reticulocalbin-3, a novel member of the CREC family, with the precursor of subtilisin-like proprotein convertase, PACE4
Biochem. J.
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2006
Homo sapiens
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Bassi, D.E.; Lopez De Cicco, R.; Cenna, J.; Litwin, S.; Cukierman, E.; Klein-Szanto, A.J.
PACE4 expression in mouse basal keratinocytes results in basement membrane disruption and acceleration of tumor progression
Cancer Res.
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2005
Rattus norvegicus
brenda
Birsoy, B.; Berg, L.; Williams, P.H.; Smith, J.C.; Wylie, C.C.; Christian, J.L.; Heasman, J.
XPACE4 is a localized pro-protein convertase required for mesoderm induction and the cleavage of specific TGFb proteins in Xenopus development
Development
132
591-602
2005
Xenopus laevis (Q5G5T8), Xenopus laevis (Q5G5T9)
brenda
Mains, R.E.
Proprotein convertase PACE4
Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , Eds. ) Academic Press
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2004
Aplysia sp., Mus musculus, Homo sapiens (P29122), Rattus norvegicus (Q63415)
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Nour, N.; Mayer, G.; Mort, J.S.; Salvas, A.; Mbikay, M.; Morrison, C.J.; Overall, C.M.; Seidah, N.G.
The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases
Mol. Biol. Cell
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5215-5226
2005
Mus musculus
brenda
Lapierre, M.; Siegfried, G.; Scamuffa, N.; Bontemps, Y.; Calvo, F.; Seidah, N.G.; Khatib, A.M.
Opposing function of the proprotein convertases furin and PACE4 on breast cancer cells malignant phenotypes: role of tissue inhibitors of metalloproteinase-1
Cancer Res.
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2007
Homo sapiens
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Page, R.E.; Klein-Szanto, A.J.; Litwin, S.; Nicolas, E.; Al-Jumaily, R.; Alexander, P.; Godwin, A.K.; Ross, E.A.; Schilder, R.J.; Bassi, D.E.
Increased expression of the pro-protein convertase furin predicts decreased survival in ovarian cancer
Cell. Oncol.
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2007
Homo sapiens
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Akamatsu, T.; Purwanti, N.; Karabasil, M.R.; Li, X.; Yao, C.; Kanamori, N.; Hosoi, K.
Temporospatially regulated expression of subtilisin-like proprotein convertase PACE4 (SPC4) during development of the rat submandibular gland
Dev. Dyn.
236
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2007
Rattus norvegicus (Q63415)
brenda
Yuasa, K.; Suzue, K.; Nagahama, M.; Matsuda, Y.; Tsuji, A.
Transcriptional regulation of subtilisin-like proprotein convertase PACE4 by E2F: possible role of E2F-mediated upregulation of PACE4 in tumor progression
Gene
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2007
Homo sapiens
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Seidah, N.G.; Mayer, G.; Zaid, A.; Rousselet, E.; Nassoury, N.; Poirier, S.; Essalmani, R.; Prat, A.
The activation and physiological functions of the proprotein convertases
Int. J. Biochem. Cell Biol.
40
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2008
Homo sapiens
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Tsuji, A.; Kanie, H.; Makise, H.; Yuasa, K.; Nagahama, M.; Matsuda, Y.
Engineering of alpha 1-antitrypsin variants selective for subtilisin-like proprotein convertases PACE4 and PC6: importance of the P2 residue in stable complex formation of the serpin with proprotein convertase
Protein Eng. Des. Sel.
20
163-170
2007
Homo sapiens
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Freyer, C.; Kilpatrick, L.M.; Salamonsen, L.A.; Nie, G.
Pro-protein convertases (PCs) other than PC6 are not tightly regulated for implantation in the human endometrium
Reproduction
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2007
Homo sapiens (P29122), Homo sapiens
brenda
Malfait, A.M.; Arner, E.C.; Song, R.H.; Alston, J.T.; Markosyan, S.; Staten, N.; Yang, Z.; Griggs, D.W.; Tortorella, M.D.
Proprotein convertase activation of aggrecanases in cartilage in situ
Arch. Biochem. Biophys.
478
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2008
Rattus norvegicus (Q78EH2)
brenda
Padua, M.B.; Hansen, P.J.
Regulation of DNA synthesis and the cell cycle in human prostate cancer cells and lymphocytes by ovine uterine serpin
BMC Cell Biol.
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5
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Mus musculus (P29121)
brenda
Akamatsu, T.; Azlina, A.; Purwanti, N.; Karabasil, M.R.; Hasegawa, T.; Yao, C.; Hosoi, K.
Inhibition and transcriptional silencing of a subtilisin-like proprotein convertase, PACE4/SPC4, reduces the branching morphogenesis of and AQP5 expression in rat embryonic submandibular gland
Dev. Biol.
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2009
Rattus norvegicus (Q78EH2)
brenda
Remacle, A.G.; Shiryaev, S.A.; Oh, E.S.; Cieplak, P.; Srinivasan, A.; Wei, G.; Liddington, R.C.; Ratnikov, B.I.; Parent, A.; Desjardins, R.; Day, R.; Smith, J.W.; Lebl, M.; Strongin, A.Y.
Substrate cleavage analysis of furin and related proprotein convertases. A comparative study
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283
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2008
Homo sapiens (P29122), Homo sapiens
brenda
Komiyama, T.; Coppola, J.M.; Larsen, M.J.; van Dort, M.E.; Ross, B.D.; Day, R.; Rehemtulla, A.; Fuller, R.S.
Inhibition of furin/PC-catalyzed surface and intracellular processing by small molecules
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284
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2009
Rattus norvegicus (Q78EH2)
brenda
Xiao, Y.; Chen, G.; Richard, J.; Rougeau, N.; Li, H.; Seidah, N.G.; Cohen, E.A.
Cell-surface processing of extracellular human immunodeficiency virus type 1 Vpr by proprotein convertases
Virology
372
384-397
2008
Homo sapiens (Q6UW60), Homo sapiens
brenda
Fuller, J.A.; Brun-Zinkernagel, A.M.; Clark, A.F.; Wordinger, R.J.
Subtilisin-like proprotein convertase expression, localization, and activation in the human retina and optic nerve head
Invest. Ophthalmol. Vis. Sci.
50
5759-5768
2009
Homo sapiens
brenda
Byun, S.; Tortorella, M.D.; Malfait, A.M.; Fok, K.; Frank, E.H.; Grodzinsky, A.J.
Transport and equilibrium uptake of a peptide inhibitor of PACE4 into articular cartilage is dominated by electrostatic interactions
Arch. Biochem. Biophys.
499
32-39
2010
Rattus norvegicus
brenda
Yuasa, K.; Masuda, T.; Yoshikawa, C.; Nagahama, M.; Matsuda, Y.; Tsuji, A.
Subtilisin-like proprotein convertase PACE4 is required for skeletal muscle differentiation
J. Biochem.
146
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2009
Mus musculus
brenda
Akamatsu, T.; Azlina, A.; Javkhlan, P.; Hasegawa, T.; Yao, C.; Hosoi, K.
Salivary gland development: its mediation by a subtilisin-like proprotein convertase, PACE4
J. Med. Invest.
56
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2009
Rattus norvegicus
brenda
Mesnard, D.; Donnison, M.; Fuerer, C.; Pfeffer, P.L.; Constam, D.B.
The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities
Genes Dev.
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2011
Mus musculus
brenda
Akamatsu, T.
Physiological role of a subtilisin - Like proprotein convertase, PACE4, in submandibular gland development
J. Oral Biosci.
52
81-93
2010
Rattus norvegicus
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brenda
Yuasa, K.; Futamatsu, G.; Kawano, T.; Muroshita, M.; Kageyama, Y.; Taichi, H.; Ishikawa, H.; Nagahama, M.; Matsuda, Y.; Tsuji, A.
Subtilisin-like proprotein convertase paired basic amino acid-cleaving enzyme 4 is required for chondrogenic differentiation in ATDC5 cells
FEBS J.
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2012
Mus musculus
brenda
Kara, I.; Poggi, M.; Bonardo, B.; Govers, R.; Landrier, J.F.; Tian, S.; Leibiger, I.; Day, R.; Creemers, J.W.; Peiretti, F.
The paired basic amino acid-cleaving enzyme 4 (PACE4) is involved in the maturation of insulin receptor isoform B: an opportunity to reduce the specific insulin receptor-dependent effects of insulin-like growth factor 2 (IGF2)
J. Biol. Chem.
290
2812-2821
2015
Homo sapiens (P29122)
brenda
Kim, H.; Tabata, A.; Tomoyasu, T.; Ueno, T.; Uchiyama, S.; Yuasa, K.; Tsuji, A.; Nagamune, H.
Estrogen stimuli promote osteoblastic differentiation via the subtilisin-like proprotein convertase PACE4 in MC3T3-E1 cells
J. Bone Miner. Metab.
33
30-39
2015
Mus musculus
brenda
Kwiatkowska, A.; Couture, F.; Levesque, C.; Ly, K.; Beauchemin, S.; Desjardins, R.; Neugebauer, W.; Dory, Y.L.; Day, R.
Novel insights into structure-activity relationships of N-terminally modified PACE4 inhibitors
ChemMedChem
11
289-301
2016
Homo sapiens (P29122)
brenda
Dianati, V.; Shamloo, A.; Kwiatkowska, A.; Desjardins, R.; Soldera, A.; Day, R.; Dory, Y.L.
Rational design of a highly potent and selective peptide inhibitor of PACE4 by salt bridge interaction with D160 at position P3
ChemMedChem
12
1169-1172
2017
Homo sapiens (P29122)
brenda
Yao, Z.; Sun, B.; Hong, Q.; Yan, J.; Mu, D.; Li, J.; Sheng, H.; Guo, H.
PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways
Drug Des. Devel. Ther.
9
5911-5923
2015
Homo sapiens (P29122), Homo sapiens
brenda
Bessonnard, S.; Mesnard, D.; Constam, D.
PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation
J. Cell Biol.
210
1185-1197
2015
Mus musculus
brenda
Lin, Y.E.; Wu, Q.N.; Lin, X.D.; Li, G.Q.; Zhang, Y.J.
Expression of paired basic amino acid-cleaving enzyme 4 (PACE4) correlated with prognosis in non-small cell lung cancer (NSCLC) patients
J. Thorac. Dis.
7
850-860
2015
Homo sapiens (P29122), Homo sapiens
brenda
Wang, F.; Wang, L.; Pan, J.
PACE4 regulates proliferation, migration and invasion in human breast cancer MDA-MB-231 cells
Mol. Med. Rep.
11
698-704
2015
Homo sapiens (P29122), Homo sapiens
brenda
Tian, X.F.; Huang, G.M.; Zang, H.L.; Cao, H.
PACE4 regulates apoptosis in human pancreatic cancer Panc-1 cells via the mitochondrial signaling pathway
Mol. Med. Rep.
14
5205-5210
2016
Homo sapiens (P29122), Homo sapiens
brenda