Any feedback?
Information on EC 3.4.24.13 - IgA-specific metalloendopeptidase
for references in articles please use BRENDA:EC3.4.24.13Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
3.4.24.13 IgA-specific metalloendopeptidaseSpecify your search results
Word Map
- 3.4.24.13
- medicine
- hinge
- gonorrhoeae
- influenzae
-
haemophilus
- proteinases
-
neisserial
-
20-year
-
colostrum
-
nontypeable
- fcalpha
-
hexxh
- meningitidis
- airways
- tetrapeptide
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Reaction Schemes
Cleavage of Pro-/-Thr bond in the hinge region of the heavy chain of human IgA
Synonyms
streptococcus pneumoniae iga1 protease, iga1 proteinase, iga protease b1, igab1, zinc metalloprotease zmpc, 
more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
HP1022
IgA protease
IgA1 protease
IgA1 proteinase
-
-
-
-
IgA1-specific proteinase
-
-
-
-
IgA1P
IgA1pr
igaB
IgaB2
immunoglobulin A1 protease
proteinase, immunoglobulin A1
-
-
-
-
zinc metalloprotease zmpC
IgA1 protease
-
-
-
-
IgA1 protease
Neisseria meningitidis serogroup B B44/76
-
-
-
IgA1 protease
-
IgA1pr
Neisseria meningitidis serogroup B B44/76
-
-
-
igaB
-
represents a second immunoglobulin A1 protease gene in nontypeable Haemophilus influenza
immunoglobulin A1 protease
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cleavage of Pro-/-Thr bond in the hinge region of the heavy chain of human IgA
localization of the cleavage site specificity determinant
-
Cleavage of Pro-/-Thr bond in the hinge region of the heavy chain of human IgA
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of peptide bond
hydrolysis of peptide bond
-
-
endopeptidase
-
hydrolysis of peptide bond
-
-
peptides, endopeptidase
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
72231-73-3
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
human immunoglobulin A1 + H2O
Fc fragment + Fab fragment
-
cleavage of the hinge region
-
-
?
human immunoglobulin A1 + H2O
immunoglobulin Fc + immunoglobulin Fab
-
cleavage of the hinge region
-
-
?
immunoglobulin A1 + H2O
immunoglobulin A1 Fabalpha fragments + immunglobulin A1 Fcalpha
-
-
-
-
?
immunoglobulin IgA1 + H2O
effector domain of IgA1 + Fab determinants of IgA1
-
-
specific cleavage of hinge region. IgA1 bound to bacterial porin A is masked by the serogroup B polysaccharide capsule and less accessible to degradation. De novo synthesis of enzyme is required for degradation of porin-A-bound IgA1, specific cleavage of hinge region
-
?
Dabcyl-gammaPRPPAPVFY-Edans + H2O
Dabcyl-gammaPRPP + APVFY-Edans
-
-
-
?
Dabcyl-gammaPRPPAPVFY-Edans + H2O
Dabcyl-gammaPRPP + APVFY-Edans
-
-
-
?
human IgA1 + H2O
?
-
-
cleavage of the peptide bond between amino acid residues 231-232 in each alpha chain
-
?
human IgA1 + H2O
?
-
IgA1 protease is a proteolytic enzyme with strict substrate specificity for human IgA1
-
-
?
human IgA1 + H2O
?
-
human IgA1 possesses a unique hinge region composed of a repeated sequence rich in proline, serine and threonine, which are the specific cleavage sites of IgA1 protease
-
-
?
human IgA1 with CH3 domain exchanged for that of human IgG1 + H2O
?
-
-
-
-
?
human IgA1 with CH3 domain exchanged for that of human IgG1 + H2O
?
-
-
-
-
?
human IgA1 with CH3 domain exchanged for that of human IgG1 + H2O
?
-
-
-
-
?
human IgA1 with CH3 domain exchanged for that of human IgG1 + H2O
?
-
-
-
-
?
human immunoglobulin A1 + H2O
?
-
specific cleavage in the hinge region
-
-
?
human immunoglobulin A1 + H2O
?
-
specific cleavage in the hinge region, the C-terminal region of enzyme IgA1P is necessary for cleavage of IgA1
-
-
?
human immunoglobulin A1 + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
-
?
human immunoglobulin A1 + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
?
human immunoglobulin A1 + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
?
human immunoglobulin A1 + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
-
?
human immunoglobulin A1 + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
-
?
human immunoglobulin A1 + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
-
?
IgA2-IgA1 half hinge + H2O
?
-
antibody with half of the IgA1 hinge region incorporated into the equivalent site in enzyme-resistant IgA2
-
-
?
IgA2-IgA1 half hinge + H2O
?
-
antibody with half of the IgA1 hinge region incorporated into the equivalent site in enzyme-resistant IgA2
-
-
?
IgA2-IgA1 half hinge + H2O
?
-
antibody with half of the IgA1 hinge region incorporated into the equivalent site in enzyme-resistant IgA2
-
-
?
IgA2-IgA1 half hinge + H2O
?
-
antibody with half of the IgA1 hinge region incorporated into the equivalent site in enzyme-resistant IgA2
-
-
?
IgA2-IgA1 half hinge + H2O
?
-
antibody with half of the IgA1 hinge region incorporated into the equivalent site in enzyme-resistant IgA2
-
-
?
IgA2-IgA1 half hinge + H2O
?
-
antibody with half of the IgA1 hinge region incorporated into the equivalent site in enzyme-resistant IgA2
-
-
?
Immunoglobulin A1 + H2O
?
-
amino acid sequence requirements in the hinge of human immunoglobulin A1. Absolute requirement for Pro227 but not for Thr228, which can be replaced by Val. Enzyme from different strains may have different amino acid requirements for cleavage
-
?
Immunoglobulin A1 + H2O
?
-
amino acid sequence requirements in the hinge of human immunoglobulin A1. Absolute requirement for Pro227 but not for Thr228, which can be replaced by Val
-
?
Immunoglobulin A1 + H2O
?
-
amino acid sequence requirements in the hinge of human immunoglobulin A1. The enzyme shows no absolute requirement for either Pro or Thr at residue 227 to 228
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
amino acid sequence requirements in the hinge of human immunoglobulin A1. Absolute requirement for Pro227 but not for Thr228, which can be replaced by Val
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
enzyme cleaves the alpha-chain at the Pro223-Ser224 bond
Fcalpha fragment + Fabalpha fragment
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
enzyme cleaves the alpha-chain at the Pro223-Ser224 bond
Fcalpha fragment + Fabalpha fragment
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
enzyme cleaves the alpha-chain at the Pro223-Ser224 bond
Fcalpha fragment + Fabalpha fragment
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
cleavage products have MW of 30000 Da and 33000 Da
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
type 1 protease cleaves peptide bond Pro231-Ser232
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
type 2 protease cleaves peptide bond 235-236
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
type 3 protease cleaves peptide bond 237-238
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
Fsalpha1 fragment + Fcalpha1 fragment
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
alpha-chain
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
type 2 enzyme cleaves peptide bond 235-236, type 1 enzyme cleaves bond 237-238 in the alpha chain of IgA
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
cleavage of peptide bond Pro235-Thr236
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
the activity level of the type 2 enzyme is 10fold that observed for the type 1 enzyme
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
type 2 protease cleaves peptide bond 235-236
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
type 1 protease cleaves peptide bond 237-238
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
enzyme cleaves the alpha-chain at the Pro223-Ser224 bond
Fcalpha fragment + Fabalpha fragment
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
enzyme cleaves the alpha-chain at the Pro223-Ser224 bond
Fcalpha fragment + Fabalpha fragment
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
specific for human IgA1
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
enzyme cleaves the alpha-chain at the Pro223-Ser224 bond
Fcalpha fragment + Fabalpha fragment
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
enzyme cleaves the alpha-chain at the Pro223-Ser224 bond
Fcalpha fragment + Fabalpha fragment
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
Streptococcus mitior
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
cleavage products have MW of 30000 Da and 33000 Da
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
cleaves peptide bond Pro227-Thr228
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
cleaves peptide bond Pro227-Thr228
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
cleavage of peptide bond Pro235-Thr236
MW of the Fabalpha fragment is 28500 Da and the MW of the Fcalpha fragement is 33000 Da
?
LAMP1 + H2O
?
-
i.e. lysosome-associated membrane protein 1. The enzyme cleaves LAMP1 thereby accelerating its degradation rate in infected A431 human epidermoid carcinoma cells and resulting in the alteration of lysosomes
-
?
LAMP1 + H2O
?
-
i.e. lysosome-associated membrane protein 1. The enzyme cleaves LAMP1 thereby accelerating its degradation rate in infected A431 human epidermoid carcinoma cells and resulting in the alteration of lysosomes. Infection of T84 monolayers also results in IgA1 protease-mediated reduction of LAMP1
-
?
LAMP1 + H2O
?
-
LAMP1 is a major integral membrane glycoprotein of lysosomes and significantly reduces its steady-state levels in an infected cell. Pilus-induced Ca2+ flux triggers lysosome exocytosis and increases the amount of LAMP1 accessible to IgA1 protease
-
?
NIVVAPPSPQANQAEEY + H2O
NIVVAPP + SPQANQAEEY
-
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 protease is an important factor of meningitis
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
retained antigen-binding activity of Fabalpha fragments of human monoclonal immunoglobulin A1 cleaved by IgA 1 protease opens the possibility that IgA1 protease-producing bacteria growing in the presence of IgA1 antibodies are coated with Fabalpha fragments. Such fragments may conceivably protect the microorganism from the immune system by blocking access of intact antibody molecules of the same or other isotypes and of immunocompetent cells
-
-
?
additional information
?
-
-
IgA1 protease of the Brazilian purpuric fever clone may contribute to the pathogenic potential of the virulent phenotype in Brazil
-
-
?
additional information
?
-
-
the enzyme cleaves myeloma IgA1 and secretory IgA but not myeloma IgA2, IgM, or IgG
-
-
?
additional information
?
-
-
enzyme requires 10 or more appropriate amino acids between the Fab and Fc region to maintain a minimum critical distance between the scissile bond and the start of the Fc
-
-
?
additional information
?
-
-
no substrate: human IgA1 with CH3 domain exchanged for that of human IgG1. CH3 domain residues E403, Q406, T409 influence sensitivity to cleavage by enzyme
-
-
?
additional information
?
-
-
all three forms of capsule-specific IgA show comparable susceptibilities to cleavage by bacterial IgA1 protease, demonstrating that secretory component does not prevent the proteolytic degradation of IgA1 by IgA1 protease. IgA1 cleavage results in formation of identical Fab fragments for each of the molecular forms, thereby abolishing the contribution of multivalence of polymeric IgA and secretory IgA
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
the enzyme could play a role in the selective host specificity of mucosal pathogens
-
-
?
additional information
?
-
-
the enzyme could play a role in the selective host specificity of mucosal pathogens
-
-
?
additional information
?
-
-
the enzyme could play a role in the selective host specificity of mucosal pathogens
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
the cleavage of IgA1 by gonococcal IgA1 protease within the lumen of the female lower genital tract is unlikely to be a significant factor in the pathogenesis of infections by Neisseria gonorrhoeae
-
-
?
additional information
?
-
-
enzyme requires 9 or more appropriate amino acids between the Fab and Fc region to maintain a minimum critical distance between the scissile bond and the start of the Fc
-
-
?
additional information
?
-
-
no substrate: human IgA1 with CH3 domain exchanged for that of human IgG1
-
-
?
additional information
?
-
-
IgA1 protease is an important factor of meningitis
-
-
?