Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,2-diethyl-3-hydroxypyridine-4(1H)-thione | - |
Streptococcus pneumoniae | |
1-ethyl-3-hydroxy-2-methylpyridine-4(1H)-thione | - |
Streptococcus pneumoniae | |
1-[2-(3-bromophenyl)ethyl]-3-hydroxy-2-methylpyridine-4(1H)-thione | - |
Streptococcus pneumoniae | |
1-[2-(3-chloro-4-methoxyphenyl)ethyl]-3-hydroxy-2-methylpyridine-4(1H)-thione | - |
Streptococcus pneumoniae | |
1-[2-(3-chlorophenyl)ethyl]-3-hydroxy-2-methylpyridine-4(1H)-thione | - |
Streptococcus pneumoniae | |
1-[2-(3-fluorophenyl)ethyl]-3-hydroxy-2-methylpyridine-4(1H)-thione | - |
Streptococcus pneumoniae | |
3-hydroxy-1,2-dimethylpyridine-4(1H)-thione | - |
Streptococcus pneumoniae | |
3-hydroxy-1-[2-(3-methoxyphenyl)ethyl]-2-methylpyridine-4(1H)-thione | - |
Streptococcus pneumoniae | |
3-hydroxy-1-[2-(4-methoxyphenyl)ethyl]-2-methylpyridine-4(1H)-thione | - |
Streptococcus pneumoniae | |
3-hydroxy-2-methyl-1-(2-phenylethyl)pyridine-4(1H)-thione | - |
Streptococcus pneumoniae | |
3-hydroxy-2-methyl-1-[2-(3-methylphenyl)ethyl]pyridine-4(1H)-thione | - |
Streptococcus pneumoniae | |
Berberine | - |
Streptococcus pneumoniae | |
norharmane | - |
Streptococcus pneumoniae | |
remerine | - |
Streptococcus pneumoniae |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Streptococcus pneumoniae | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | contains zinc | Streptococcus pneumoniae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
immunoglobulin A1 + H2O | Streptococcus pneumoniae | - |
immunoglobulin A1 Fabalpha fragments + immunglobulin A1 Fcalpha | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus pneumoniae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
immunoglobulin A1 + H2O | - |
Streptococcus pneumoniae | immunoglobulin A1 Fabalpha fragments + immunglobulin A1 Fcalpha | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IgA1P | - |
Streptococcus pneumoniae |
immunoglobulin A1 protease | - |
Streptococcus pneumoniae |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0043 | - |
in 50 mM Tris-HCl, pH 7.0, at 37°C | Streptococcus pneumoniae | 1-[2-(3-chlorophenyl)ethyl]-3-hydroxy-2-methylpyridine-4(1H)-thione | |
0.00498 | - |
in 50 mM Tris-HCl, pH 7.0, at 37°C | Streptococcus pneumoniae | 1-[2-(3-chloro-4-methoxyphenyl)ethyl]-3-hydroxy-2-methylpyridine-4(1H)-thione | |
0.00614 | - |
in 50 mM Tris-HCl, pH 7.0, at 37°C | Streptococcus pneumoniae | 1-[2-(3-bromophenyl)ethyl]-3-hydroxy-2-methylpyridine-4(1H)-thione | |
0.00664 | - |
in 50 mM Tris-HCl, pH 7.0, at 37°C | Streptococcus pneumoniae | 3-hydroxy-1-[2-(3-methoxyphenyl)ethyl]-2-methylpyridine-4(1H)-thione | |
0.007 | - |
in 50 mM Tris-HCl, pH 7.0, at 37°C | Streptococcus pneumoniae | 3-hydroxy-1-[2-(4-methoxyphenyl)ethyl]-2-methylpyridine-4(1H)-thione | |
0.00774 | - |
in 50 mM Tris-HCl, pH 7.0, at 37°C | Streptococcus pneumoniae | 1-[2-(3-fluorophenyl)ethyl]-3-hydroxy-2-methylpyridine-4(1H)-thione | |
0.00914 | - |
in 50 mM Tris-HCl, pH 7.0, at 37°C | Streptococcus pneumoniae | 3-hydroxy-2-methyl-1-[2-(3-methylphenyl)ethyl]pyridine-4(1H)-thione | |
0.0127 | - |
in 50 mM Tris-HCl, pH 7.0, at 37°C | Streptococcus pneumoniae | 3-hydroxy-2-methyl-1-(2-phenylethyl)pyridine-4(1H)-thione | |
0.0231 | - |
in 50 mM Tris-HCl, pH 7.0, at 37°C | Streptococcus pneumoniae | remerine | |
0.0523 | - |
in 50 mM Tris-HCl, pH 7.0, at 37°C | Streptococcus pneumoniae | Berberine | |
0.152 | - |
in 50 mM Tris-HCl, pH 7.0, at 37°C | Streptococcus pneumoniae | norharmane | |
0.887 | - |
in 50 mM Tris-HCl, pH 7.0, at 37°C | Streptococcus pneumoniae | 1-ethyl-3-hydroxy-2-methylpyridine-4(1H)-thione | |
0.962 | - |
in 50 mM Tris-HCl, pH 7.0, at 37°C | Streptococcus pneumoniae | 1,2-diethyl-3-hydroxypyridine-4(1H)-thione | |
1.3 | - |
in 50 mM Tris-HCl, pH 7.0, at 37°C | Streptococcus pneumoniae | 3-hydroxy-1,2-dimethylpyridine-4(1H)-thione |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme catalyzes the proteolysis of human IgA1 at its hinge region to leave the bacterial cell surface masked by IgA1 Fab, enabling the bacteria to evade the host's immune system and adhere to host epithelial cells to promote colonization | Streptococcus pneumoniae |