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Literature summary for 3.4.24.13 extracted from

  • Fu, L.; Zhao, J.; Lin, L.; Zhang, Q.; Xu, Z.; Han, L.; Xie, C.; Zhou, R.; Jin, M.; Zhang, A.
    Characterization of IgA1 protease as a surface protective antigen of Streptococcus suis serotype 2 (2016), Microbes Infect., 18, 285-289 .
    View publication on PubMed
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Application

Application Comment Organism
medicine IgA1 protease is a surface protective antigen of Streptococcus suis serotype 2 (SS2), immunization with purified recombinant IgA1 protease (amino acid residues 600-1926) induces high IgG antibody titers and confers complete protection against a challenge with a lethal dose of SS2 in a mouse model. rIgAP emulsified with a Marcol 52-based adjuvant can induce high titers of specific IgG antibodies, including high levels of antibodies with bactericidal activity in the presence of phagocytes, as well as confer good protection against SS2 infection. The virulence-associated protein IgA1 protease is a protective antigen and one of promising and effective vaccine candidates against SS2 Streptococcus suis DAT1

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface surface distribution of IgA1 protease on SS2 strain ZYS, overview Streptococcus suis DAT1 9986
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Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ dependent on Streptococcus suis DAT1

Organism

Organism UniProt Comment Textmining
Streptococcus suis DAT1 A0A0Z8E9X6 isolated from the brain of a diseased piglet collected during the 2005 Sichuan outbreak in China that expressed MRP, EF, and SLY
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Streptococcus suis DAT1 SC-19 A0A0Z8E9X6 isolated from the brain of a diseased piglet collected during the 2005 Sichuan outbreak in China that expressed MRP, EF, and SLY
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Streptococcus suis DAT1 ZYS A0A0Z8E9X6 isolated from the brain of a diseased piglet collected during the 2005 Sichuan outbreak in China that expressed MRP, EF, and SLY
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Synonyms

Synonyms Comment Organism
IgA1 protease
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 Streptococcus suis DAT1
zinc metalloprotease zmpC UniProt Streptococcus suis DAT1

General Information

General Information Comment Organism
additional information IgA1 protease is a surface protective antigen of Streptococcus suis serotype 2 (SS2), immunization with purified recombinant IgA1 protease (amino acid residues 600-1926) induces high IgG antibody titers and confers complete protection against a challenge with a lethal dose of SS2 in a BALB/c mouse model Streptococcus suis DAT1
physiological function the virulence-associated protein, IgA1 protease, is a surface protective antigen of SS2 Streptococcus suis DAT1