Literature summary for 3.4.24.13 extracted from

Gallo, M.C.; Kirkham, C.; Eng, S.; Bebawee, R.S.; Kong, Y.; Pettigrew, M.M.; Tettelin, H.; Murphy, T.F.
Changes in IgA protease expression are conferred by changes in genomes during persistent infection by nontypeable Haemophilus influenzae in chronic obstructive pulmonary disease (2018), Infect. Immun., 86, e00313-18 .

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Cloned(Commentary)

Cloned (Comment)	Organism
gene igA2, genotyping and expression analysis	Haemophilus influenzae NTHI
gene igB1, genotyping and expression analysis	Haemophilus influenzae NTHI

Organism

Organism	UniProt	Comment	Textmining
Haemophilus influenzae NTHI	-	nontypeable Haemophilus influenzae	-

Synonyms

Synonyms	Comment	Organism
IgA protease A2	-	Haemophilus influenzae NTHI
IgA protease B1	-	Haemophilus influenzae NTHI
igA2	-	Haemophilus influenzae NTHI
igaB1	-	Haemophilus influenzae NTHI

General Information

General Information	Comment	Organism
evolution	expression of IgA proteases is variable from strain to strain among NTHi. Analysis of IgA protease expression by 101 persistent strains (median duration of persistence) collected longitudinally from patients enrolled in a 20-year study of COPD upon initial acquisition and immediately before clearance from the host. Upon acquisition, 89 (88%) express IgA protease. A total of 16 of 101 (16%) strains of NTHi alter expression of IgA protease during persistence. Indels and slipped-strand mispairing of mononucleotide repeats confer changes in expression of igaA2. Mechanism of changes in expression, overview	Haemophilus influenzae NTHI
physiological function	nontypeable Haemophilus influenzae (NTHi) expresses four IgA protease variants (A1, A2, B1, and B2) that play different roles in virulence	Haemophilus influenzae NTHI

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Release 2023.1 (January 2023)