Reference on EC 3.1.99.B1 - flap endonuclease-1
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Williams, R.; Sengerova, B.; Osborne, S.; Syson, K.; Ault, S.; Kilgour, A.; Chapados, B.R.; Tainer, J.A.; Sayers, J.R.; Grasby, J.A.
Comparison of the catalytic parameters and reaction specificities of a phage and an archaeal flap endonuclease
J. Mol. Biol.
371
34-48
2007
Archaeoglobus fulgidus, Archaeoglobus fulgidus (O29975), Tequintavirus T5
Vallur, A.C.; Maizels, N.
Complementary roles for exonuclease 1 and Flap endonuclease 1 in maintenance of triplet repeats
J. Biol. Chem.
285
28514-28519
2010
Homo sapiens
Vallur, A.C.; Maizels, N.
Distinct activities of exonuclease 1 and flap endonuclease 1 at telomeric g4 DNA
PLoS ONE
5
e8908
2010
Homo sapiens
Mase, T.; Kubota, K.; Miyazono, K.; Kawarabayasi, Y.; Tanokura, M.
Structure of flap endonuclease 1 from the hyperthermophilic archaeon Desulfurococcus amylolyticus
Acta Crystallogr. Sect. F
67
209-213
2011
Desulfurococcus amylolyticus, Desulfurococcus amylolyticus (F2Z289)
Tsutakawa, S.E.; Classen, S.; Chapados, B.R.; Arvai, A.S.; Finger, L.D.; Guenther, G.; Tomlinson, C.G.; Thompson, P.; Sarker, A.H.; Shen, B.; Cooper, P.K.; Grasby, J.A.; Tainer, J.A.
Human flap endonuclease structures, DNA double-base flipping, and a unified understanding of the FEN1 superfamily
Cell
145
198-211
2011
Homo sapiens
Gloor, J.W.; Balakrishnan, L.; Bambara, R.A.
Flap endonuclease 1 mechanism analysis indicates flap base binding prior to threading
J. Biol. Chem.
285
34922-34931
2010
Homo sapiens
Jagannathan, I.; Pepenella, S.; Hayes, J.J.
Activity of FEN1 endonuclease on nucleosome substrates is dependent upon DNA sequence but not flap orientation
J. Biol. Chem.
286
17521-17529
2011
Homo sapiens
Fortini, B.K.; Pokharel, S.; Polaczek, P.; Balakrishnan, L.; Bambara, R.A.; Campbell, J.L.
Characterization of the endonuclease and ATP-dependent flap endo/exonuclease of Dna2
J. Biol. Chem.
286
23763-23770
2011
Homo sapiens
Tomlinson, C.G.; Syson, K.; Sengerova, B.; Atack, J.M.; Sayers, J.R.; Swanson, L.; Tainer, J.A.; Williams, N.H.; Grasby, J.A.
Neutralizing mutations of carboxylates that bind metal 2 in T5 flap endonuclease result in an enzyme that still requires two metal ions
J. Biol. Chem.
286
30878-30887
2011
Tequintavirus T5
Dorjsuren, D.; Kim, D.; Maloney, D.J.; Wilson, D.M.; Simeonov, A.
Complementary non-radioactive assays for investigation of human flap endonuclease 1 activity
Nucleic Acids Res.
39
e11
2011
Homo sapiens
Collins, B.K.; Tomanicek, S.J.; Lyamicheva, N.; Kaiser, M.W.; Mueser, T.C.
A preliminary solubility screen used to improve crystallization trials: crystallization and preliminary X-ray structure determination of Aeropyrum pernix flap endonuclease-1
Acta Crystallogr. Sect. D
60
1674-1678
2004
Aeropyrum pernix
Mase, T.; Kubota, K.; Miyazono, K.; Kawarabayasi, Y.; Tanokura, M.
Crystallization and preliminary X-ray analysis of flap endonuclease 1 (FEN1) from Desulfurococcus amylolyticus
Acta Crystallogr. Sect. F
65
923-925
2009
Desulfurococcus amylolyticus (F2Z289), Desulfurococcus amylolyticus
Henneke, G.
In vitro reconstitution of RNA primer removal in Archaea reveals the existence of two pathways
Biochem. J.
447
271-280
2012
Pyrococcus abyssi (Q9V0P9)
Horie, M.; Fukui, K.; Xie, M.; Kageyama, Y.; Hamada, K.; Sakihama, Y.; Sugimori, K.; Matsumoto, K.
The N-terminal region is important for the nuclease activity and thermostability of the flap endonuclease-1 from Sulfolobus tokodaii
Biosci. Biotechnol. Biochem.
71
855-865
2007
Sulfurisphaera tokodaii (Q976H6), Sulfurisphaera tokodaii, Sulfurisphaera tokodaii 7 (Q976H6)
Chapados, B.R.; Hosfield, D.J.; Han, S.; Qiu, J.; Yelent, B.; Shen, B.; Tainer, J.A.
Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair
Cell
116
39-50
2004
Archaeoglobus fulgidus (O29975)
Hosfield, D.J.; Mol, C.D.; Shen, B.; Tainer, J.A.
Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity
Cell
95
135-146
1998
Pyrococcus furiosus (O93634), Pyrococcus furiosus
Beattie, T.R.; Bell, S.D.
Coordination of multiple enzyme activities by a single PCNA in archaeal Okazaki fragment maturation
EMBO J.
31
1556-1567
2012
Saccharolobus solfataricus (Q980U8)
Rao, H.G.; Rosenfeld, A.; Wetmur, J.G.
Methanococcus jannaschii flap endonuclease: expression, purification, and substrate requirements
J. Bacteriol.
180
5406-5412
1998
Methanocaldococcus jannaschii (Q58839), Methanocaldococcus jannaschii
Hosfield, D.J.; Frank, G.; Weng, Y.; Tainer, J.A.; Shen, B.
Newly discovered archaebacterial flap endonucleases show a structure-specific mechanism for DNA substrate binding and catalysis resembling human flap endonuclease-1
J. Biol. Chem.
273
27154-27161
1998
Archaeoglobus fulgidus (O29975), Methanocaldococcus jannaschii (Q58839), Methanocaldococcus jannaschii, Pyrococcus furiosus (O93634), Pyrococcus furiosus
Matsui, E.; Kawasaki, S.; Ishida, H.; Ishikawa, K.; Kosugi, Y.; Kikuchi, H.; Kawarabayashi, Y.; Matsui, I.
Thermostable flap endonuclease from the archaeon, Pyrococcus horikoshii, cleaves the replication fork-like structure endo/exonucleolytically
J. Biol. Chem.
274
18297-18309
1999
Pyrococcus horikoshii (O50123), Pyrococcus horikoshii
Matsui, E.; Musti, K.V.; Abe, J.; Yamasaki, K.; Matsui, I.; Harata, K.
Molecular structure and novel DNA binding sites located in loops of flap endonuclease-1 from Pyrococcus horikoshii
J. Biol. Chem.
277
37840-37847
2002
Pyrococcus horikoshii (O50123), Pyrococcus horikoshii
Matsui, E.; Abe, J.; Yokoyama, H.; Matsui, I.
Aromatic residues located close to the active center are essential for the catalytic reaction of flap endonuclease-1 from hyperthermophilic archaeon Pyrococcus horikoshii
J. Biol. Chem.
279
16687-16696
2004
Pyrococcus horikoshii (O50123), Pyrococcus horikoshii
Bae, K.W.; Baek, K.W.; Cho, C.S.; Hwang, K.Y.; Kim, H.-R.; Sung, H.-C.; Cho, Y.
Expression, purification, characterization and crystallization of flap endonuclease-1 from Methanococcus jannaschii
Mol. Cells
9
45-48
1999
Methanocaldococcus jannaschii (Q58839), Methanocaldococcus jannaschii
Hwang, K.Y.; Baek, K.; Kim, H.-Y.; Cho, Y.
The crystal structure of flap endonuclease-1 from Methanococcus jannaschii
Nat. Struct. Biol.
5
707-713
1998
Methanocaldococcus jannaschii (Q58839), Methanocaldococcus jannaschii
Dor, A.S.; Kilkenny, M.L.; Jones, S.A.; Oliver, A.W.; Roe, S.M.; Bell, S.D.; Pearl, L.H.
Structure of an archaeal PCNA1-PCNA2-FEN1 complex: elucidating PCNA subunit and client enzyme specificity
Nucleic Acids Res.
34
4515-4526
2006
Archaeoglobus fulgidus (O29975)
Matsui, E.; Urushibata, Y.; Abe, J.; Matsui, I.
Serial intermediates with a 1 nt 3'-flap and 5' variable-length flaps are formed by cooperative functioning of Pyrococcus horikoshii FEN-1 with either B or D DNA polymerases
Extremophiles
18
415-427
2014
Pyrococcus horikoshii (O50123), Pyrococcus horikoshii, Pyrococcus horikoshii OT-3 (O50123)
Matsui, E.; Abe, J.; Yokoyama, H.; Matsui, I.
Aromatic residues located close to the active center are essential for the catalytic reaction of flap endonuclease-1 from hyperthermophilic archaeon Pyrococcus horikoshii
J. Biol. Chem.
279
16687-16696
2004
Pyrococcus horikoshii (O50123), Pyrococcus horikoshii, Pyrococcus horikoshii OT-3 (O50123)
Sgrignani, J.; Magistrato, A.
QM/MM MD simulations on the enzymatic pathway of the human flap endonuclease (hFEN1) elucidating common cleavage pathways to RNase H enzymes
ACS Catal.
5
3864-3875
2015
Homo sapiens (P39748)
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