Literature summary for 3.1.99.B1 extracted from

Vallur, A.C.; Maizels, N.
Complementary roles for exonuclease 1 and Flap endonuclease 1 in maintenance of triplet repeats (2010), J. Biol. Chem., 285, 28514-28519.

Search for more literature for 3.1.99.B1

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	the enzyme is inhibited by G4 structures formed by CGG repeats in duplex regions adjacent to 5'-flaps. hFEN1 5'-flap cleavage is impaired by CTG or CGG repeats	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	Human FEN1 can cleave 5'-flaps bearing structures formed by CTG or CGG repeats, although less efficiently than unstructured flaps. hFEN1 is not affected by the stem-loops formed by CTG repeats interrupting duplex regions adjacent to 5'-flaps, but the enzyme is inhibited by G4 structures formed by CGG repeats in analogous positions. hFEN1 binding causes hypersensitivity near the flap/duplex junction. FEN1 can eliminate structures formed by trinucleotide repeats in the course of replication, relying on endonucleolytic activities	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	Human FEN1 can cleave 5'-flaps bearing structures formed by CTG or CGG repeats, although less efficiently than unstructured flaps. hFEN1 is not affected by the stem-loops formed by CTG repeats interrupting duplex regions adjacent to 5'-flaps, but the enzyme is inhibited by G4 structures formed by CGG repeats in analogous positions. hFEN1 binding causes hypersensitivity near the flap/duplex junction. FEN1 can eliminate structures formed by trinucleotide repeats in the course of replication, relying on endonucleolytic activities	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
FEN1	-	Homo sapiens
flap endonuclease 1	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)