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Information on EC 2.6.1.29 - diamine transaminase
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2.6.1.29 diamine transaminaseSpecify your search results
Word Map
- 2.6.1.29
- riboflavin
- fmn
-
2.7.1.26
-
5'-phosphotransferase
- mononucleotide
- flavokinase
- 5'-phosphate
-
monofunctional
- orthophosphate
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Reaction Schemes
Synonyms
amine transaminase, amine-ketoacid transaminase, aminotransferase, diamine, diamine aminotransferase, diamine-ketoglutaric transaminase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
amine transaminase
-
-
-
-
amine-ketoacid transaminase
-
-
-
-
aminotransferase, diamine
-
-
-
-
diamine aminotransferase
-
-
-
-
diamine-ketoglutaric transaminase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
an alpha,omega-diamine + 2-oxoglutarate = an omega-aminoaldehyde + L-glutamate
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
amino group transfer
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
diamine:2-oxoglutarate aminotransferase
-
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CAS REGISTRY NUMBER
COMMENTARY
9031-83-8
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(+)-1,4-diaminobutan-2-ol + 2-oxoglutarate
?
-
30% of the activity with putrescine
-
-
-
1,6-diaminohexane + 2-oxoglutarate
6-aminohexanal + L-glutamate
-
-
-
?
1,7-diaminoheptane + 2-oxoglutarate
7-aminoheptanal + L-glutamate
-
30% of the activity with putrescine
-
?
1,7-diaminoheptane + 2-oxoglutarate
7-aminoheptanal + L-glutamate
-
30% of the activity with putrescine
-
?
4-aminobutanoate + 2-oxoglutarate
4-oxobutanoate + L-glutamate
-
-
-
?
4-aminobutanoate + 2-oxoglutarate
4-oxobutanoate + L-glutamate
-
11% of the activity with putrescine
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
-
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
-
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
equally active as putrescine
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
equally active as putrescine
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
-
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
-
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
-
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
-
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
-
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
-
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
-
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
-
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
-
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
-
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
-
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
-
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
-
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
-
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
-
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
-
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
-
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
-
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
additional information
?
-
-
inactive with 1,3-diaminopropane, lysine, ornithine, spermidine
-
-
-
additional information
?
-
-
inactive with 1,3-diaminopropane, lysine, ornithine, spermidine
-
-
-
additional information
?
-
-
inactive with histamine, tyramine, 4-aminobutanol, beta-alanine
-
-
-
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
cadaverine + 2-oxoglutarate
5-aminopentanal + L-glutamate
-
enzyme catalyzes the second step in lysine catabolism
-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
pyridoxal 5'-phosphate
-
purified enzyme normally active without added pyridoxal phosphate, absolute requirement when irradiated with UV light or treated with 2 mM phenylhydrazine and then with Norite
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
0.00064
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
8 - 10.5
-
almost completely inactive at pH 7, pH 8 about 40% of maximum activity, pH 10.5 about 20% of maximum activity
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
37
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
Sequence
Q1IZ18_DEIGD
Deinococcus geothermalis (strain DSM 11300)
492
0
53520
TrEMBL
I4D743_DESAJ
Desulfosporosinus acidiphilus (strain DSM 22704 / JCM 16185 / SJ4)
454
0
49538
TrEMBL
L0R9B9_9DELT
460
0
50331
TrEMBL
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
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PURIFICATION/commentary
ORGANISM
UNIPROT
LITERATURE
precipitation with ammonium sulphate followed by column chromatography
-
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kim, K.H.
Purification and properties of a diamine alpha-ketoglutarate transaminase from Escherichia coli
J. Biol. Chem.
239
783-786
1964
Escherichia coli
brenda
Kim, K.H.; Tchen, T.T.
Diamine-alpha-ketoglutarate aminotransferase (Escherichia coli)
Methods Enzymol.
17B
812-815
1971
Escherichia coli
-
brenda
Bascarán, V.; Sánchez, L.; Hardisson, C.; Braña, A.F.
Stringent response and initiation of secondary metabolism in Streptomyces clavuligerus
J. Gen. Microbiol.
137
1625-1634
1991
Streptomyces clavuligerus
brenda
Madduri, K.; Stuttard, C.; Vining, L.C.
Lysine catabolism in Streptomyces spp. is primarily through cadaverine: beta-lactam producers also make alpha-aminoadipate
J. Bacteriol.
171
299-302
1989
Amycolatopsis lactamdurans, Amycolatopsis lactamdurans NRRL 3802, Streptomyces clavuligerus, Streptomyces clavuligerus NRRL 3585, Streptomyces glaucescens, Streptomyces glaucescens GLAO, Streptomyces griseus, Streptomyces griseus NRRL 3851, Streptomyces lividans, Streptomyces lividans TK24, Streptomyces parvulus, Streptomyces parvulus ISP5048, Streptomyces phaeochromogenes, Streptomyces phaeochromogenes B2196, Streptomyces rimosus, Streptomyces rimosus NRRL 2234, Streptomyces venezuelae, Streptomyces venezuelae ISP5230, Streptomyces viridochromogenes, Streptomyces viridochromogenes CUB416
brenda
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