Ligand 1,3-diaminopropane

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of 1,3-diaminopropane (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C3H10N2
1,3-diaminopropane
KHWCHTKSEGGWEX-RRKCRQDMSA-N
Synonyms:
1,3-propanediamine, an alkane-alpha,omega-diamine, an alpha,omega-diamine, diaminopropane, propane-1,3-diamine


Show all pahtways known for Show all BRENDA pathways known for 1,3-diaminopropane

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-aspartic 4-semialdehyde + 1,3-diaminopropane + NADPH + H+ = carboxynorspermidine + NADP+ + H2O
show the reaction diagram
-
L-aspartate 4-semialdehyde + propane-1,3-diamine + NADPH + H+ = carboxynorspermidine + H2O + NADP+
show the reaction diagram
-
acetyl-CoA + 1,3-diaminopropane = CoA + ?
show the reaction diagram
-
S-adenosyl 3-(methylthio)propylamine + propane-1,3-diamine = S-methyl-5'-thioadenosine + norspermidine
show the reaction diagram
-
S-adenosylmethioninamine + propane-1,3-diamine = 5'-methylthioadenosine + N-(3-aminopropyl)-1,3-diaminopropane
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
spermidine + cytochrome c = 1,3-diaminopropane + gamma-aminobutylaldehyde
show the reaction diagram
-
putrescine + spermidine = sym-homospermidine + propane-1,3-diamine
show the reaction diagram
L-2,4-diaminobutanoate = propane-1,3-diamine + CO2
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (20 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1,3-diaminopropane + NAD+ + H2O = ?
show the reaction diagram
-
L-aspartic 4-semialdehyde + 1,3-diaminopropane + NADPH + H+ = carboxynorspermidine + NADP+ + H2O
show the reaction diagram
-
1,3-diaminopropane + O2 + H2O = 3-aminopropanal + NH3 + H2O2
show the reaction diagram
-
1,3-diaminopropane + H2O + O2 = 3-aminopropanal + NH3 + H2O2
show the reaction diagram
-
1,3-diaminopropane + H2O + 2,6-dichlorophenol indophenol = ? + NH3 + reduced 2,6-dichlorophenol indophenol
show the reaction diagram
-
carbamoyl phosphate + 1,3-diaminopropane = phosphate + N1-carbamoyl-1,3-diaminopropane
show the reaction diagram
-
caffeoyl-CoA + diaminopropane = CoA + N-caffeoyl-1,3-diaminopropane
show the reaction diagram
-
S-adenosyl 3-(methylthio)propylamine + propane-1,3-diamine = 5'-S-methyl-5'-thioadenosine + bis(3-aminopropyl)amine
show the reaction diagram
-
S-adenosyl 3-(methylthio)propylamine + propane-1,3-diamine = S-methyl-5'-thioadenosine + norspermidine
show the reaction diagram
-
S-adenosyl 3-(methylthio)propylamine + propane-1,3-diamine = S-methyl-5'-thioadenosine + norspermidine
show the reaction diagram
-
S-adenosyl-(5')-3-methylthio-1-propylamine + 1,3-diaminopropane = ?
show the reaction diagram
-
putrescine + 1,3-diaminopropane = homospermidine + spermidine
show the reaction diagram
mesaconate + propane-1,3-diamine = ?
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (61 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
spermidine + O2 + H2O = 4-aminobutyraldehyde + 1,3-diaminopropane + H2O2
show the reaction diagram
-
spermidine + H2O + O2 = 1,3-diaminopropane + NH3 + H2O2
show the reaction diagram
-
carboxynorspermidine + H2O + NADP+ = L-aspartate 4-semialdehyde + propane-1,3-diamine + NADPH + H+
show the reaction diagram
-
N1-benzyl-propane-1,3-diamine + O2 + H2O = propane-1,3-diamine + H2O2 + benzylalcohol
show the reaction diagram
-
N8-acetylspermidine + O2 + H2O = 1,3-diaminopropane + ?
show the reaction diagram
-
N-(3-aminopropyl)acetamide + H2O = propane-1,3-diamine + acetate
show the reaction diagram
-
L-2,4-diaminobutanoate = 1,3-diaminopropane + CO2
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
supports aminoacylation in presence of crude tRNA not in presence of resolved tRNA
-

Inhibitor in Enzyme-catalyzed Reactions (21 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
86% of initial activity at 0.5 mM
-
10 mM, 88% inhibition in the presence of 0.5 mM N-acetyl-L-glutamate
-
competitive
-
product inhibition, about 50% at 5 mM
-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (3 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.06
-
pH 7.4, 70°C

KM Value (12 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
2.9
-
-
1.88
-
pH 7.4, 70°C
1.675
-
pH 7.5, 78°C

Ki Value (6 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.1
-
pH 6.0, 25°C
0.0063
-
-
0.0129
-
-
35
-
pH 8.0, 37°C

References & Links

Links to other databases for 1,3-diaminopropane

ChEBI
PubChem
-
PubChem