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Information on EC 2.3.1.254 - N-terminal methionine Nalpha-acetyltransferase NatB

for references in articles please use BRENDA:EC2.3.1.254
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IUBMB Comments
N-terminal acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus and makes the N-terminal residue larger and more hydrophobic, and may also play a role in membrane targeting and gene silencing. The NatB complex is found in all eukaryotic organisms, and specifically targets N-terminal L-methionine residues attached to Asn, Asp, Gln, or Glu residues at the second position.
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Word Map
  • 2.3.1.254
  • anti-fcepsilonri
  • auxiliary
  • ige
  • substrate-specific
  • alpha-chain
  • arylamine
  • meiosis
  • fcepsilonri
  • fcepsilonri-mediated
  • basophils
  • cross-linkage
The enzyme appears in viruses and cellular organisms
Reaction Schemes
hide(3 overall reactions are displayed. Show all (4)>>)
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an N-terminal L-methionyl-L-asparaginyl-[protein]
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an N-terminal Nalpha-acetyl-L-methionyl-L-asparaginyl-[protein]
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an N-terminal L-methionyl-L-glutaminyl-[protein]
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an N-terminal Nalpha-acetyl-L-methionyl-L-glutaminyl-[protein]
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an N-terminal L-methionyl-L-aspartyl-[protein]
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an N-terminal Nalpha-acetyl-L-methionyl-L-aspartyl-[protein]
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Synonyms
cra-1, naa50p, naa20, naa25, n-acetyltransferase 3, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acetyl-CoA + an N-terminal L-methionyl-L-asparaginyl-[protein] = an N-terminal Nalpha-acetyl-L-methionyl-L-asparaginyl-[protein] + CoA
show the reaction diagram
(1)
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acetyl-CoA + an N-terminal L-methionyl-L-aspartyl-[protein] = an N-terminal Nalpha-acetyl-L-methionyl-L-aspartyl-[protein] + CoA
show the reaction diagram
(3)
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acetyl-CoA + an N-terminal L-methionyl-L-glutaminyl-[protein] = an N-terminal Nalpha-acetyl-L-methionyl-L-glutaminyl-[protein] + CoA
show the reaction diagram
(2)
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acetyl-CoA + an N-terminal L-methionyl-L-glutamyl-[protein] = an N-terminal Nalpha-acetyl-L-methionyl-L-glutamyl-[protein] + CoA
show the reaction diagram
(4)
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