EC Number   |
General Information |
Reference |
|---|
   2.3.1.254 | evolution |
Nat3p and Mdm20p subunits form a heterodimer, named NatB, which is a member of the NAT family |
756403 |
| 2.3.1.254 | evolution |
Nat3p and Mdm20p subunits form a heterodimer, named NatB, which is a member of the NAT family. Each NAT family member preferentially catalyzes the N-terminal acetylation of the N-terminal amino acid of its target proteins. NatB prefers to acetylate proteins beginning with Met-Asp, Met-Glu, and Met-Asn in yeast and mammals |
-, 756403 |
| 2.3.1.254 | evolution |
the family of N-terminal acetyltransferases (NATs) has six subtypes with their unique substrate specificity, NatA-NatF. The substrate specificity of Nats is determined by the first two amino acids of the substrate protein/peptide. NatB has a unique substrate specificity different from all other NATs, which requires acidic amino acids or their amides at the second position |
-, 758486 |
| 2.3.1.254 | malfunction |
enzyme knockdown disrupts normal cell-cycle progression and induces cell growth inhibition. Enzyme knockdown results in an increase in G0/G1-phase cells |
740011 |
| 2.3.1.254 | malfunction |
Naa25 inactivation is embryonic lethal in homozygocity. Recombinant Bax accumulates in the mitochondria of Naa25-/- MEF cells, but does not promote cytochrome c release, suggesting that an additional step is required for full activation of Bax |
-, 756931 |
| 2.3.1.254 | malfunction |
recombinant Bax accumulates in the mitochondria of yeast naa20DELTA (W303 naa20DELTA), but does not promote cytochrome c release, suggesting that an additional step is required for full activation of Bax |
-, 756931 |
| 2.3.1.254 | malfunction |
shutoff activity of influenza A viral PA-X is suppressed in NatB-deficient cells, and PA-X mutants that are not acetylated by NatB show reduced shutoff activities. Polymerase acidic proteins (PAs) that are not acetylated by NatB lost their function in the viral polymerase complex |
-, 756403 |
| 2.3.1.254 | metabolism |
the enzyme controls the levels of acetyl-coenzyme A by antagonizing the acetyl-CoA hydrolase ACER-1 |
741225 |
| 2.3.1.254 | more |
Naa20 and Naa25 are the components of enzyme complex NatB |
756403 |
| 2.3.1.254 | more |
Nat3p (equivalent to human NAA20) and Mdm20p (equivalent to human NAA25) are the components of enzyme complex NatB |
-, 756403 |
