Ligand coenzyme A

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Basic Ligand Information

Molecular Structure
Picture of coenzyme A (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C21H36N7O16P3S
coenzyme A
RGJOEKWQDUBAIZ-IBOSZNHHSA-N
Synonyms:
CoA, CoA-SH, CoA-[4'-phosphopantetheine], CoASH, coenzyme-A, HS-CoA, reduced CoA

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (403 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
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3-oxopropanoate + CoA + NAD+ = acetyl-CoA + CO2 + NADH
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pyruvate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH
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2-oxoglutarate + CoA + NADP+ = succinyl-CoA + CO2 + NADPH
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phenylglyoxylate + NAD+ + CoA-SH = benzoyl-S-CoA + CO2 + NADH
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coniferaldehyde + CoA + NADP+ = feruloyl-CoA + NADPH + H+
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propanal + CoA + NAD+ = propanoyl-CoA + NADH + H+
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pyruvate + CoA + NAD+ = acetyl-CoA + CO2 + NADH
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3-hydroxy-5-phosphonooxypentane-2,4-dione + coenzyme A = glycerone phosphate + acetyl-CoA
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CoA + acetyl phosphate = acetyl-CoA + phosphate
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coenzyme A + H2O = ?
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ATP + biotin + CoA = ?
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ATP + acetate + CoA = ADP + phosphate + acetyl-CoA
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ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA
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ATP + citrate + CoA = ADP + phosphate + (3S)-citryl-CoA
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ATP + phytanate + CoA = ?
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ATP + 4-hydroxybenzoate + CoA = AMP + diphosphate + 4-hydroxybenzoyl-CoA
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ATP + 3alpha,7alpha-dihydroxy-5beta-cholestanate + CoA = ?
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ferulic acid + CoASH + ATP = trans-feruloyl-CoA + products of ATP breakdown
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3-hydroxypropanoate + ATP + coenzyme A = 3-hydroxypropanoyl-CoA + AMP + diphosphate
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ATP + 3-hydroxybenzoate + CoA = AMP + diphosphate + 3-hydroxybenzoyl-CoA
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[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetate + ATP + CoA = AMP + diphosphate + [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA
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ATP + 4-hydroxybutanoate + CoA = AMP + diphosphate + 4-hydroxybutanoyl-CoA
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ATP + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + CoA = AMP + diphosphate + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA
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ATP + 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + CoA = AMP + diphosphate + 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA
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ATP + L-carnitine + CoA = AMP + diphosphate + L-carnitinyl-CoA
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ATP + L-firefly luciferin + CoA = AMP + diphosphate + L-firefly luciferyl-CoA
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ATP + 2-succinylbenzoate + CoA = ADP + phosphate + 2-succinylbenzoyl-CoA
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ATP + 2-(imidazol-4-yl)acetate + CoA = ADP + phosphate + 2-(imidazol-4-yl)acetyl-CoA
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3-phenylpropanoate + CoA + ATP = 3-phenylpropionyl-CoA + AMP + diphosphate
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In Vivo Product in Enzyme-catalyzed Reactions (1569 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(3,5-dihydroxyphenyl)acetyl-CoA + O2 = (3,5-dihydroxyphenyl)glyoxylate + CoA
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malonyl-CoA + NADPH = malonate-semialdehyde + CoA + NADP+
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tetradecanoyl-CoA + NADPH = tetradecanal + CoA + NADP+
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sulfoacetyl-CoA + NADPH + H+ = 2-sulfoacetaldehyde + CoA + NADP+
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stearoyl-CoA + NADPH = octadecanal + CoA + NADP+
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CoA-glutathione + GSH = CoA + GSSG
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acetyl-CoA + hydrogen sulfide = CoA + thioacetate
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palmitoyl-CoA + myelin proteolipid protein = CoA + myelin proteolipid O-palmitoylprotein
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acetyl-CoA + L-N6-hydroxylysine = CoA + N6-acetyl-N6-hydroxylysine
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acetyl-CoA + 1-alkyl-sn-glycero-3-phosphate = CoA + 1-alkyl-2-acetyl-sn-glycero-3-phosphate
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acetyl-CoA + thioethanolamine = CoA + S-acetylthioethanolamine
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feruloyl-CoA + tyramine = CoA + feruloyltyramine
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eicosanoyl-CoA + 4 methylmalonyl-CoA + 8 NADPH + 8 H+ = tetramethyl-branched mycocerosoyl-CoA + 4 CoA + 4 CO2 + 8 NADP+ + 4 H2O
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malonyl-CoA + D-tryptophan = CoA + N2-malonyl-D-tryptophan
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malonyl-CoA + 3,4-dichloroaniline = CoA + N-(3,4-dichlorophenyl)-malonamate
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apigenin 7-O-apiosylglucoside + malonyl-CoA = apigenin 7-O-apiosylglucoside -6''-O-malonylester + CoA
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malonyl-CoA + kaempferol 3-O-glucoside = CoA + kaempferol 3-O-glucoside malonylester
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acyl-CoA + 1-alkenylglycerophosphoethanolamine = CoA + 1-alkenyl-2-acylglycerophosphoethanolamine
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caffeoyl-CoA + isocitrate = CoA + 2-caffeoylisocitrate
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benzoyl-CoA + L-ornithine = CoA + N2,N5-dibenzoyl-L-ornithine
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acyl-CoA + glycine = CoA + N-acylglycine
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sinapoyl-CoA + glucarolactone = CoA + O-sinapoylglucarolactone
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caffeoyl-CoA + putrescine = CoA + N-caffeoylputrescine
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phenylacetyl-CoA + L-glutamine = CoA + alpha-N-phenylacetyl-L-glutamine
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(E,E)-piperoyl-CoA + piperidine = CoA + N-[(E,E)-piperoyl]-piperidine
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cinnamoyl-CoA + malonyl-CoA = 3,5-dihydroxystilbene + CoA + CO2
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acetyl-CoA + salutaridinol = CoA + 7-O-acetylsalutaridinol
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benzoyl-CoA + malonyl-CoA = 2,4,6-trihydroxybenzophenone + CoA + CO2
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myristoyl-CoA + acetyl-CoA = 3-oxopalmitoyl-CoA + CoA
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malonyl-CoA + N-methylanthraniloyl-CoA = CoA + 1,3-dihydroxy-N-methylacridone + CO2
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acetyl-CoA + 16-epivellosimine = CoA + vinorine
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acetyl-CoA + 10-desacetyltaxuyunnanin C = CoA + taxuyunnanin C
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benzoyl-CoA + 10-deacetyl-2-debenzoylbaccatin III = CoA + 10-deacetylbaccatin III
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2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine
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acetyl-CoA + corrinoid protein = CoA + CO + methylcorrinoid protein
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malonyl-CoA + 4-coumaroyl-CoA + NADPH + H+ = CoA + isoliquiritigenin + CO2 + NADP+ + H2O
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malonyl-CoA + delphinidin 3-O-beta-D-glucoside = CoA + delphinidin 3-O-(6-malonyl-beta-D-glucoside)
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4-coumaroyl-CoA + a flavonol 3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] = CoA + a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside]
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acetyl-CoA + deacetylcephalosporin C = CoA + cephalosporin C
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acetyl-CoA + L-2,4-diaminobutanoate = CoA + N4-acetyl-L-2,4-diaminobutanoate
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butanoyl-CoA + phosphate = butanoylphosphate + CoA
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[elongator tRNAMet]-cytidine34 + ATP + acetyl-CoA = [elongator tRNAMet]-N4-acetylcytidine34 + ADP + phosphate + coenzyme A
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a very-long-chain acyl-CoA + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + coenzyme A
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acetyl-CoA + imidazole = CoA + N-acetylimidazole
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acetyl-CoA + fumigaclavine B = CoA + fumigaclavine A
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3 malonyl-CoA + hexanoyl-CoA = 3 CoA + 3,5,7-trioxododecanoyl-CoA + 3 CO2
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octanoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2
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acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose = CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-glucose
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acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose = CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose
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4-coumaroyl-CoA + malonyl-CoA + H2O = 2 CoA + 4-hydroxybenzalacetone + 2 CO2
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3 malonyl-CoA + benzoyl-CoA = 4 CoA + 2,4,6-trihydroxybenzophenone + 3 CO2
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7 malonyl-CoA + hexanoyl-[acyl-carrier protein] = 7 CoA + norsolorinic acid anthrone + [acyl-carrier protein] + 7 CO2 + 2 H2O
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propanoyl-CoA + phosphate = CoA + propanoyl phosphate
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acetyl-CoA + GDP-4-amino-4,6-dideoxy-alpha-D-mannose = CoA + GDP-4-acetamido-4,6-dideoxy-alpha-D-mannose
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isovaleryl-CoA + S-adenosyl-L-methionine = CoA + S-methyl-5'-thioadenosine + N-isovaleryl-L-homoserine lactone
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4-coumaroyl-CoA + S-adenosyl-L-methionine = CoA + S-methyl-5'-thioadenosine + N-(4-coumaroyl)-L-homoserine lactone
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malonyl-CoA + 2-aminobenzoyl-CoA = 2 CoA + 4-hydroxy-2(1H)-quinolone + CO2
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anthraniloyl-CoA + methanol = CoA + O-methyl anthranilate
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10 malonyl-CoA = tetracenomycin F2 + 10 CoA + 10 CO2 + 2 H2O
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acetyl-CoA + 5 malonyl-CoA + 3 NADPH + 3 H+ = 5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 4 H2O + 3 NADP+
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acetyl-CoA + 5 malonyl-CoA + 2 NADPH + 2 H+ = 2-hydroxy-5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 3 H2O + 2 NADP+
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malonyl-CoA + 5 (2S)-methylmalonyl-CoA + 5 NADPH + 5 H+ = 10-deoxymethynolide + 6 CoA + 6 CO2 + 5 NADP+ + 2 H2O
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malonyl-CoA + 6 (2S)-methylmalonyl-CoA + 5 NADPH + 5 H+ = narbonolide + 7 CoA + 7 CO2 + 5 NADP+ + 2 H2O
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acetyl-CoA + malonyl-CoA + [2-methylbutanoate polyketide synthase] + 2 NADPH + 2 H+ + S-adenosyl-L-methionine = (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CoA + CO2 + 2 NADP+ + S-adenosyl-L-homocysteine + H2O
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2 sinapoyl-CoA + spermidine = 2 CoA + N1,N8-bis(sinapoyl)-spermidine
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2 4-coumaroyl-CoA + spermidine = 2 CoA + N1,N8-bis(4-coumaroyl)-spermidine
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