Reference on EC 1.3.1.124 - 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Clejan, S.; Schulz, H.
Effect of growth hormone on fatty acid oxidation: growth hormone increases the activity of 2,4-dienoyl-CoA reductase in mitochondria
Arch. Biochem. Biophys.
246
820-828
1986
Rattus norvegicus
Osmundsen, H.; Cervenka, J.; Bremer, J.
A role for 2,4-enoyl-CoA reductase in mitochondrial beta-oxidation of polyunsaturated fatty acids. Effects of treatment with clofibrate on oxidation of polyunsaturated acylcarnitines by isolated rat liver mitochondria
Biochem. J.
208
749-757
1982
Rattus norvegicus
Dommes, V.; Baumgart, C.; Kunau, W.H.
Degradation of unsaturated fatty acids in peroxisomes. Existence of a 2,4-dienoyl-CoA reductase pathway
J. Biol. Chem.
256
8259-8262
1981
Rattus norvegicus
Kunau, W.H.; Dommes, P.
Degradation of unsaturated fatty acids. Identification of intermediates in the degradation of cis-4-decenoyl-CoA by extracts of beef-liver mitochondria
Eur. J. Biochem.
91
533-544
1978
Bos taurus
Kunau, W.H.; Dommes, V.; Dommes, P.
Degradation of unsaturated fatty acids. 4-Enoyl-CoA reductase: purification, characterization and physiological function
Prog. Lipid Res.
20
327-330
1981
Bos taurus
Hiltunen, J.K.; Davis, E.J.
Metabolism of pent-4-enoate in rat heart. Reduction of the double bond
Biochem. J.
194
427-432
1981
Rattus norvegicus, Rattus norvegicus Wistar
Borrebaek, B.; Osmundsen, H.; Christiansen, E.N.; Bremer, J.
Increased 4-enoyl-CoA reductase activity in liver mitochondria of rats fed high-fed diets and its effect on fatty acid oxidation and the inhibitory action of pent-4-enoate
FEBS Lett.
121
23-24
1980
Rattus norvegicus
Borrebaek, B.; Osmundsen, H.; Bremer, J.
In vivo induction of 4-enoyl-CoA reductase by clofibrate in liver mitochondria and its effect on pent-4-enoate metabolism
Biochem. Biophys. Res. Commun.
93
1173-1180
1980
Rattus norvegicus
Roe, C.R.; Millington, D.S.; Norwood, D.L.; Sprecher, H.; Mohammed, B.S.; Nada, M.; Schulz, H.; McVie, R.
2,4-Dienolyl-coenzyme A reductase deficiency: a possible new disorder of fatty acid oxidation
J. Clin. Invest.
85
1703-1707
1990
Homo sapiens
Koivuranta, K.T.; Hakkola, E.H.; Hiltunen, J.K.
Isolation and characterization of cDNA for human 120 kDa mitochondrial 2,4-dienoyl-coenzyme A reductase
Biochem. J.
304
787-792
1994
Homo sapiens
Mizugaki, M.; Hirose, A.; Suzuki, H.; Miura, K.; Edo, K.; Tomioka, Y.
Subcellular distribution of rat liver NADPH-2,4-dienoyl-CoA reductase
Biol. Pharm. Bull.
19
176-181
1996
Rattus norvegicus
Fillgrove, K.L.; Anderson, V.E.; Mizugaki, M.
Cloning, expression, and purification of the functional 2,4-dienoyl-CoA reductase from rat liver mitochondria
Protein Expr. Purif.
17
57-63
1999
Rattus norvegicus
Geisbrecht, B.V.; Liang, X.; Morrell, J.C.; Schulz, H.; Gould, S.J.
The mouse gene PDCR encodes a peroxisomal DELTA2, DELTA4-dienoyl-CoA reductase
J. Biol. Chem.
274
25814-25820
1999
Mus musculus
Yu, W.; Chu, X.; Chen, G.; Li, D.
Studies of human mitochondrial 2,4-dienoyl-CoA reductase
Arch. Biochem. Biophys.
434
195-200
2005
Homo sapiens
Alphey, M.S.; Yu, W.; Byres, E.; Li, D.; Hunter, W.N.
Structure and reactivity of human mitochondrial 2,4-dienoyl-CoA reductase: enzyme-ligand interactions in a distinctive short-chain reductase active site
J. Biol. Chem.
280
3068-3077
2005
Homo sapiens
Robert, J.; Marchesini, S.; Delessert, S.; Poirier, Y.
Analysis of the beta-oxidation of trans-unsaturated fatty acid in recombinant Saccharomyces cerevisiae expressing a peroxisomal PHA synthase reveals the involvement of a reductase-dependent pathway
BIOCHIM. BIOPHYS. ACTA
1734
169-177
2005
Saccharomyces cerevisiae
Hiltunen, J.K.; Filppula, S.A.; Haeyrinen, H.M.; Koivuranta, K.T.; Hakkola, E.H.
Peroxisomal beta-oxidation of polyunsaturated fatty acids
Biochimie
75
175-182
1993
Rattus norvegicus
Hiltunen, J.K.
Peroxisomes and beta-oxidation of long-chain unsaturated carboxylic acids
Scand. J. Clin. Lab. Invest. Suppl.
204
33-46
1991
Rattus norvegicus
Miinalainen, I.; Schmitz, W.; Huotari, A.; Autio, K.; Soininen, R.; Van Themaat, E.; Baes, M.; Herzig, K.; Conzelmann, E.; Hiltunen, J.
Mitochondrial 2,4-dienoyl-CoA reductase deficiency in mice results in severe hypoglycemia with stress intolerance and unimpaired ketogenesis
PLOS Genet.
5
e1000543
2009
Mus musculus
Satoh, M.; Haruta-Satoh, E.; Yamada, M.; Kado, S.; Nomura, F.
Overexpression of hydroxymethylglutaryl CoA synthase 2 and 2,4-dienoyl-CoA reductase in rat pancreas following chronic alcohol consumption
Pancreas
42
475-482
2013
Rattus norvegicus
Li, T.P.; Zhu, R.G.; Dong, Y.P.; Liu, Y.H.; Li, S.H.; Chen, G.
Effects of pectin pentaoligosaccharide from Hawthorn (Crataegus pinnatifida Bunge. var. Major) on the activity and mRNA levels of enzymes involved in fatty acid oxidation in the liver of mice fed a high-fat diet
J. Agric. Food Chem.
61
7599-7605
2013
Mus musculus
Luthria, D.; Baykousheva, S.; Sprecher, H.
Double bond removal from odd-numbered carbons during peroxisomal beta-oxidation of arachidonic acid requires both 2,4-dienoyl-CoA reductase and DELTA3,5,DELTA2,4-dienoyl-CoA isomerase
J. Biol. Chem.
270
13771-13776
1995
Rattus norvegicus (Q9Z2M4)
Gurvitz, A.; Wabnegger, L.; Yagi, A.I.; Binder, M.; Hartig, A.; Ruis, H.; Hamilton, B.; Dawes, I.W.; Hiltunen, J.K.; Rottensteiner, H.
Function of human mitochondrial 2,4-dienoyl-CoA reductase and rat monofunctional Delta3-Delta2-enoyl-CoA isomerase in beta-oxidation of unsaturated fatty acids
Biochem. J.
344 Pt 3
903-914
1999
Homo sapiens (Q16698)
Fillgrove, K.L.; Anderson, V.E.
The mechanism of dienoyl-CoA reduction by 2,4-dienoyl-CoA reductase is stepwise observation of a dienolate intermediate
Biochemistry
40
12412-12421
2001
Rattus norvegicus
De Nys, K.; Meyhi, E.; Mannaerts, G.P.; Fransen, M.; Van Veldhoven, P.P.
Characterisation of human peroxisomal 2,4-dienoyl-CoA reductase
Biochim. Biophys. Acta
1533
66-72
2001
Homo sapiens (Q9NUI1)
Dommes, V.; Luster, W.; Cvetanovi?, M.; Kunau, W.H.
Purification by affinity chromatography of 2,4-dienoyl-CoA reductases from bovine liver and Escherichia coli
Eur. J. Biochem.
125
335-341
1982
Bos taurus
Hakkola, E.H.; Hiltunen, J.K.
The existence of two mitochondrial isoforms of 2,4-dienoyl-CoA reductase in the rat
Eur. J. Biochem.
215
199-204
1993
Rattus norvegicus (Q64591)
Yokota, S.; Tomioka, Y.; Suzuki, H.; Mizugaki, M.
Immunocytochemical localization of delta 3, delta 2-enoyl-CoA isomerase and NADPH-dependent-2,4-dienoyl-CoA reductase in rat kidney
Histochemistry
99
463-469
1993
Rattus norvegicus
Kimura, C.; Kondo, A.; Koeda, N.; Yamanaka, H.; Mizugaki, M.
Studies on the metabolism of unsaturated fatty acids. XV. Purification and properties of 2,4-dienoyl-CoA reductase from rat liver peroxisomes
J. Biochem.
96
1463-1469
1984
Rattus norvegicus (Q9Z2M4)
Mizugaki, M.; Koeda, N.; Kondo, A.; Kimura, C.; Yamanaka, H.
Studies on the metabolism of unsaturated fatty acids. XVI. Purification and general properties of 2,4-dienoyl-CoA reductase from Candida lipolytica
J. Biochem.
97
837-843
1985
Yarrowia lipolytica
Dommes, P.; Dommes, V.; Kunau, W.H.
beta-Oxidation in Candida tropicalis. Partial purification and biological function of an inducible 2,4-dienoyl coenzyme A reductase
J. Biol. Chem.
258
10846-10852
1983
Candida tropicalis
Gurvitz, A.; Rottensteiner, H.; Kilpelaeinen, S.H.; Hartig, A.; Hiltunen, J.K.; Binder, M.; Dawes, I.W.; Hamilton, B.
The Saccharomyces cerevisiae peroxisomal 2,4-dienoyl-CoA reductase is encoded by the oleate-inducible gene SPS19
J. Biol. Chem.
272
22140-22147
1997
Saccharomyces cerevisiae (P32573), Saccharomyces cerevisiae
Geisbrecht, B.; Liang, X.; Morrell, J.; Schulz, H.; Gould, S.
The mouse gene PDCR encodes a peroxisomal DELTA2,DELTA4-dienoyl-CoA reductase
J. Biol. Chem.
274
25814-25820
1999
Mus musculus (Q9WV68)
Gurvitz, A.; Rottensteiner, H.; Hiltunen, J.K.; Binder, M.; Dawes, I.W.; Ruis, H.; Hamilton, B.
Regulation of the yeast SPS19 gene encoding peroxisomal 2,4-dienoyl-CoA reductase by the transcription factors Pip2p and Oaf1p beta-oxidation is dispensable for Saccharomyces cerevisiae sporulation in acetate medium
Mol. Microbiol.
26
675-685
1997
Saccharomyces cerevisiae (P32573), Saccharomyces cerevisiae
Blomme, A.; Ford, C.; Mui, E.; Patel, R.; Ntala, C.; Jamieson, L.; Planque, M.; McGregor, G.; Peixoto, P.; Hervouet, E.; Nixon, C.; Salji, M.; Gaughan, L.; Markert, E.; Repiscak, P.; Sumpton, D.; Blanco, G.; Lilla, S.; Kamphorst, J.; Graham, D.; Faulds, K
2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer
Nat. Commun.
11
2508
2020
Homo sapiens (Q16698)
Chu, X.; Yu, W.; Chen, G.; Li, D.
Expression, purification, and characterization of His-tagged human mitochondrial 2,4-dienoyl-CoA reductase
Protein Expr. Purif.
31
292-297
2003
Homo sapiens (Q16698)
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