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Information on EC 1.14.14.78 - phylloquinone omega-hydroxylase

for references in articles please use BRENDA:EC1.14.14.78
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IUBMB Comments
A heme-thiolate protein (cytochrome P-450). Isolated from human tissue. The enzyme will also act on menaquinone-4. Prolonged action of CYP4F2, but not CYP4F11, on the omega hydroxyl group oxidizes it to the corresponding carboxylic acid. CYP4F2 also oxidizes leukotriene B4; see EC 1.14.13.30, leukotriene-B4 20-monooxygenase .
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The enzyme appears in viruses and cellular organisms
Synonyms
CYP4F11, CYP4F14, CYP4F2, cytochrome P450 4F11, leukotriene B4 omega-hydroxylase, vitamin K1 omega-hydroxylase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
phylloquinone + [reduced NADPH-hemoprotein reductase] + O2 = omega-hydroxyphylloquinone + [oxidized NADPH-hemoprotein reductase] + H2O
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