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Literature summary for 1.14.14.78 extracted from

  • Farley, S.M.; Leonard, S.W.; Taylor, A.W.; Birringer, M.; Edson, K.Z.; Rettie, A.E.; Traber, M.G.
    omega-Hydroxylation of phylloquinone by CYP4F2 is not increased by alpha-tocopherol (2013), Mol. Nutr. Food Res., 57, 1785-1793.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.14.78

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus CYP4F2 discriminates between tocopherols and phylloquinone in vitro, but alpha-tocopherol does not apparently increase phylloquinone omega-hydroxylation by this mechanism ?
-
 ?
phylloquinone + [reduced NADPH-hemoprotein reductase] + O2 Rattus norvegicus
-
 omega-hydroxyphylloquinone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
gamma-tocopherol + [reduced NADPH-hemoprotein reductase] + O2
-
 Rattus norvegicus 13'-hydroxy-gamma-tocopherol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
additional information CYP4F2 discriminates between tocopherols and phylloquinone in vitro, but alpha-tocopherol does not apparently increase phylloquinone omega-hydroxylation by this mechanism Rattus norvegicus ?
-
 ?
phylloquinone + [reduced NADPH-hemoprotein reductase] + O2
-
 Rattus norvegicus omega-hydroxyphylloquinone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CYP4F2
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Rattus norvegicus