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Information on EC 1.1.1.17 - mannitol-1-phosphate 5-dehydrogenase
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EC Tree
1.1.1.17 mannitol-1-phosphate 5-dehydrogenaseSpecify your search results
Word Map
- 1.1.1.17
- fructose-6-phosphate
- mannitol-1-phosphatase
-
mannitol-specific
-
phosphoenolpyruvate-dependent
- ectocarpus
- arabitol
-
1-phosphatase
-
mannitol-producing
- synthesis
- agriculture
- analysis
- pharmacology
The enzyme appears in viruses and cellular organisms
Synonyms
mannitol-1-phosphate dehydrogenase, mannitol 1-phosphate dehydrogenase, m1pdh, d-mannitol-1-phosphate dehydrogenase, mannitol 1-phosphate 5-dehydrogenase, bbmpd, mannitol-1-phosphate 5-dehydrogenase, esm1pdh1, mtl-1-p dehydrogenase, esm1pdh2, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
BMMGA3_01075
BMMGA3_RS01080
D-mannitol-1-phosphate dehydrogenase
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-
-
-
dehydrogenase, mannitol 1-phosphate
-
-
-
-
fructose 6-phosphate reductase
-
-
-
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HAD hydrolase, family IA, variant 3
hexose reductase
-
-
-
-
HMPREF0010_00722
M1PDH
M1PDH1
M1PDH2
M1PDH3
mannitol 1-phosphate 5-dehydrogenase
mannitol 1-phosphate dehydrogenase
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-
-
-
mannitol-1-phosphate dehydrogenase
MpdA
MPDH
Mtl-1-P dehydrogenase
MtlD
additional information
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+
-
-
-
-
D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+
the hydride transfer is strongly rate-determining for the overall enzymatic reaction
D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+
the phosphate moiety in Man-ol1P and Fru6P is essential for substrate recognition and/or catalysis by Aspergillus fumigatus M1PDH. Binding of D-mannitol 1-phosphate and NAD+ is random, whereas D-fructose 6-phosphate binds only after NADH has bound to the enzyme. Hydride transfer is rate-determining for D-mannitol 1-phosphate oxidation by AfM1PDH. The enzyme behaves kinetically as a fructose 6-phosphate reductase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
intramolecular phosphate transfer
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-
-
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oxidation
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-
-
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redox reaction
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-
-
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reduction
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-
-
-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
D-mannitol-1-phosphate:NAD+ 5-oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY
9028-24-4
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
D-mannitol 1-phosphate + 3-acetylpyridine-NAD+
D-fructose 6-phosphate + ?
-
7% of the activity compared to NAD+
-
?
D-mannitol 1-phosphate + acetylpyridine adenine dinucleotide
D-fructose 6-phosphate + ?
-
50% of the activity compared to NAD+
-
?
D-mannitol 1-phosphate + dichlorophenolindophenol
D-fructose 6-phosphate + reduced dichlorophenolindophenol
-
higher activity than for NAD+
-
?
D-mannitol 1-phosphate + nicotinamide 6-(2-hydoxyethylamino) purine dinucleotide
D-fructose 6-phosphate + ?
-
75% of the activity compared to NAD+
-
?
D-mannitol 1-phosphate + nicotinamide hypoxanthine dinucleotide
D-fructose 6-phosphate + ?
-
84% of the activity compared to NAD+
-
?
D-sorbitol 6-phosphate + NAD+
D-glucose 6-phosphate + NADH + H+
-
38.8% of the activity compared to D-mannitol 1-phosphate
-
r
ethanol + NAD+
acetaldehyde + NADH
-
56% of the activity compared to D-mannitol 1-phosphate
-
r
D-arabitol 1-phosphate + NAD+
D-xylulose 5-phosphate + NADH + H+
-
-
-
r
D-arabitol 1-phosphate + NAD+
D-xylulose 5-phosphate + NADH + H+
-
-
-
r
D-arabitol 1-phosphate + NAD+
D-xylulose 5-phosphate + NADH + H+
-
-
-
r
D-arabitol 1-phosphate + NAD+
D-xylulose 5-phosphate + NADH + H+
-
-
-
r
D-fructose 6-phosphate + NADH + H+
D-mannitol 1-phosphate + NAD+
-
-
-
?
D-fructose 6-phosphate + NADH + H+
D-mannitol 1-phosphate + NAD+
-
-
-
?
D-fructose 6-phosphate + NADH + H+
D-mannitol 1-phosphate + NAD+
-
-
-
-
r
D-fructose 6-phosphate + NADH + H+
D-mannitol 1-phosphate + NAD+
-
-
-
-
r
D-fructose 6-phosphate + NADH + H+
D-mannitol 1-phosphate + NAD+
-
-
-
r
D-fructose 6-phosphate + NADPH + H+
D-mannitol 1-phosphate + NADP+
-
-
-
?
D-fructose 6-phosphate + NADPH + H+
D-mannitol 1-phosphate + NADP+
-
-
-
?
D-fructose 6-phosphate + NADPH + H+
D-mannitol 1-phosphate + NADP+
-
-
-
-
r
D-fructose 6-phosphate + NADPH + H+
D-mannitol 1-phosphate + NADP+
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
the enzyme is involved in mannitol biosynthesis, which is required for plant pathogenicity by Alternaria alternata, overview
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
the enzyme is involved in mannitol biosynthesis, which is required for plant pathogenicity by Alternaria alternata, overview
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
?
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
M1PDH is stereospecific for transferring the hydrogen to NAD+, in situ proton NMR studies of enzymatic oxidation of D-5-[2H]-mannitol 1-phosphate, overview
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-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
AfM1PDH primarily functions as a D-fructose-6-phosphate reductase and is specific for its natural pair of substrates
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-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
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highly specific for both substrates
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r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
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random bi-bi kinetic with two dead-end complexes
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r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
the enzyme shows higher activity in the reduction reaction
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-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
Ectocarpus siliculosus Ec32 / CCAP 1310/4
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-
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r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
Ectocarpus siliculosus Ec32 / CCAP 1310/4
the enzyme shows higher activity in the reduction reaction
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r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
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-
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r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
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part of the phosphoenolpyruvate phosphotransferase system
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?
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
highly specific for both substrates
-
?
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
highly specific for both substrates
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
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favours reverse reaction
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r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
highly specific for both substrates
-
?
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
?
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
?
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
the enzyme competes with two sorbitol-6-phosphate dehydrogenase for D-fructose 6-phosphate, metabolic flux in engineered organisms, overview
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r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
?
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
?
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
?
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
?
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
highly specific for both substrates
-
?
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
part of the phosphoenolpyruvate phosphotransferase system
-
?
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
-
r
D-mannitol 1-phosphate + NADP+
D-fructose 6-phosphate + NADPH + H+
-
-
-
r
D-mannitol 1-phosphate + NADP+
D-fructose 6-phosphate + NADPH + H+
-
-
-
r
additional information
?
-
MtlD is a bifunctional enzyme of mannitol biosynthesis that combines mannitol-1-phosphate dehydrogenase and phosphatase activities in a single polypeptide chain
-
-
?
additional information
?
-
MtlD is a bifunctional enzyme of mannitol biosynthesis that combines mannitol-1-phosphate dehydrogenase and phosphatase activities in a single polypeptide chain
-
-
?
additional information
?
-
-
important role for Lys213 in the catalytic mechanism of M1PDH
-
-
?
additional information
?
-
-
M1PDH does not catalyze the oxidation of D-mannitol, D-sorbitol, D-ribitol, xylitol, D-xylose, L-xylose, D-glucose, D-mannose, L-arabinose, D-arabinose, D-galactose, L-fucose, and D-lyxose. The enzyme is also inactive above a level of 1% activity with D-fructose 6-phosphate for reduction of D-fructose, L-sorbose, D-xylulose, D-fructose 1,6-bisphosphate, D-glucose 6-phosphate, and D-glucose 1-phosphate
-
-
?
additional information
?
-
-
required for assimilation of mannitol and glucitol
-
-
?
additional information
?
-
-
high specificity for substrates fructose-6-phosphate/NADH and mannitol-1-phosphate/NAD+, no substrate: fructose-1-phosphate, fructose-1,6-bisphosphate, glucose-1-phosphate, NADPH, NADP+
-
-
?
additional information
?
-
mannitol is present in large amounts in brown algae, where its synthesis involved two steps: a mannitol-1-phosphate dehydrogenase (M1PDH) catalyzes a reversible reaction between fructose-6-phosphate (F6P) and mannitol-1-phosphate (M1P) (EC 1.1.1.17), and a mannitol-1-phosphatase hydrolyzes M1P to mannitol (EC 3.1.3.22)
-
-
?
additional information
?
-
mannitol is present in large amounts in brown algae, where its synthesis involved two steps: a mannitol-1-phosphate dehydrogenase (M1PDH) catalyzes a reversible reaction between fructose-6-phosphate (F6P) and mannitol-1-phosphate (M1P) (EC 1.1.1.17), and a mannitol-1-phosphatase hydrolyzes M1P to mannitol (EC 3.1.3.22)
-
-
?
additional information
?
-
mannitol is present in large amounts in brown algae, where its synthesis involved two steps: a mannitol-1-phosphate dehydrogenase (M1PDH) catalyzes a reversible reaction between fructose-6-phosphate (F6P) and mannitol-1-phosphate (M1P) (EC 1.1.1.17), and a mannitol-1-phosphatase hydrolyzes M1P to mannitol (EC 3.1.3.22)
-
-
?
additional information
?
-
EsM1PDH1cat isozyme is specific for D-fructose 6-phosphate and D-mannitol 1-phosphate
-
-
?
additional information
?
-
EsM1PDH1cat isozyme is specific for D-fructose 6-phosphate and D-mannitol 1-phosphate
-
-
?
additional information
?
-
EsM1PDH1cat isozyme is specific for D-fructose 6-phosphate and D-mannitol 1-phosphate
-
-
?
additional information
?
-
no activity with D-glucose 6-phosphate, sorbitol 6-phosphate, D-fructose 1-phosphate
-
-
?
additional information
?
-
-
no activity with D-glucose 6-phosphate, sorbitol 6-phosphate, D-fructose 1-phosphate
-
-
?
additional information
?
-
-
Petunia hybrida (Hook) Vilm. cv. Mitchell is transformed with an Escherichia coli gene encoding mannitol 1-phosphate dehydrogenase. The high-mannitol containing lines are more tolerant of chilling stress than the low mannitol containing transgenic lines and wild-type. In the higher mannitol lines only 0.04% to 0.06% of the total osmotic potential generated from all solutes can be attributed to mannitol, thus its action is more like that of an osmoprotectant rather than an osmoregulator
-
-
?
additional information
?
-
mannitol 1-phosphate metabolism is required for sporulation in planta of the wheat pathogen Stagonospora nodorum
-
-
?
additional information
?
-
-
mannitol 1-phosphate metabolism is required for sporulation in planta of the wheat pathogen Stagonospora nodorum
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
D-fructose 6-phosphate + NADH + H+
D-mannitol 1-phosphate + NAD+
-
-
-
-
r
D-fructose 6-phosphate + NADPH + H+
D-mannitol 1-phosphate + NADP+
-
-
-
-
r
D-sorbitol 6-phosphate + NAD+
D-glucose 6-phosphate + NADH + H+
-
38.8% of the activity compared to D-mannitol 1-phosphate
-
r
ethanol + NAD+
acetaldehyde + NADH
-
56% of the activity compared to D-mannitol 1-phosphate
-
r
D-arabitol 1-phosphate + NAD+
D-xylulose 5-phosphate + NADH + H+
-
-
-
r
D-arabitol 1-phosphate + NAD+
D-xylulose 5-phosphate + NADH + H+
-
-
-
r
D-arabitol 1-phosphate + NAD+
D-xylulose 5-phosphate + NADH + H+
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
the enzyme is involved in mannitol biosynthesis, which is required for plant pathogenicity by Alternaria alternata, overview
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
the enzyme is involved in mannitol biosynthesis, which is required for plant pathogenicity by Alternaria alternata, overview
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
?
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
AfM1PDH primarily functions as a D-fructose-6-phosphate reductase and is specific for its natural pair of substrates
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
highly specific for both substrates
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
random bi-bi kinetic with two dead-end complexes
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
the enzyme shows higher activity in the reduction reaction
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
Ectocarpus siliculosus Ec32 / CCAP 1310/4
the enzyme shows higher activity in the reduction reaction
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
part of the phosphoenolpyruvate phosphotransferase system
-
?
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
highly specific for both substrates
-
?
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
highly specific for both substrates
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
favours reverse reaction
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
highly specific for both substrates
-
?
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
?
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
?
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
the enzyme competes with two sorbitol-6-phosphate dehydrogenase for D-fructose 6-phosphate, metabolic flux in engineered organisms, overview
-
-
r
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
?
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
?
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
highly specific for both substrates
-
?
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
part of the phosphoenolpyruvate phosphotransferase system
-
?
D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
-
-
-
-
r
D-mannitol 1-phosphate + NADP+
D-fructose 6-phosphate + NADPH + H+
-
-
-
r
D-mannitol 1-phosphate + NADP+
D-fructose 6-phosphate + NADPH + H+
-
-
-
r
additional information
?
-
MtlD is a bifunctional enzyme of mannitol biosynthesis that combines mannitol-1-phosphate dehydrogenase and phosphatase activities in a single polypeptide chain
-
-
?
additional information
?
-
MtlD is a bifunctional enzyme of mannitol biosynthesis that combines mannitol-1-phosphate dehydrogenase and phosphatase activities in a single polypeptide chain
-
-
?
additional information
?
-
-
required for assimilation of mannitol and glucitol
-
-
?
additional information
?
-
mannitol is present in large amounts in brown algae, where its synthesis involved two steps: a mannitol-1-phosphate dehydrogenase (M1PDH) catalyzes a reversible reaction between fructose-6-phosphate (F6P) and mannitol-1-phosphate (M1P) (EC 1.1.1.17), and a mannitol-1-phosphatase hydrolyzes M1P to mannitol (EC 3.1.3.22)
-
-
?
additional information
?
-
mannitol is present in large amounts in brown algae, where its synthesis involved two steps: a mannitol-1-phosphate dehydrogenase (M1PDH) catalyzes a reversible reaction between fructose-6-phosphate (F6P) and mannitol-1-phosphate (M1P) (EC 1.1.1.17), and a mannitol-1-phosphatase hydrolyzes M1P to mannitol (EC 3.1.3.22)
-
-
?
additional information
?
-
mannitol is present in large amounts in brown algae, where its synthesis involved two steps: a mannitol-1-phosphate dehydrogenase (M1PDH) catalyzes a reversible reaction between fructose-6-phosphate (F6P) and mannitol-1-phosphate (M1P) (EC 1.1.1.17), and a mannitol-1-phosphatase hydrolyzes M1P to mannitol (EC 3.1.3.22)
-
-
?
additional information
?
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Petunia hybrida (Hook) Vilm. cv. Mitchell is transformed with an Escherichia coli gene encoding mannitol 1-phosphate dehydrogenase. The high-mannitol containing lines are more tolerant of chilling stress than the low mannitol containing transgenic lines and wild-type. In the higher mannitol lines only 0.04% to 0.06% of the total osmotic potential generated from all solutes can be attributed to mannitol, thus its action is more like that of an osmoprotectant rather than an osmoregulator
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mannitol 1-phosphate metabolism is required for sporulation in planta of the wheat pathogen Stagonospora nodorum
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mannitol 1-phosphate metabolism is required for sporulation in planta of the wheat pathogen Stagonospora nodorum
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