EC Number   |
General Information |
Reference |
|---|
    1.1.1.17 | evolution |
sequence analysis suggests that algal and apicomplexa M1PDHs represent a distinct type of mannitol-1-phosphate dehydrogenase in the PSLDR family |
741122 |
| 1.1.1.17 | evolution |
the C-terminus of MtlD from Acinetobacter baylyi is similar to dehydrogenase domains found in other dehydrogenases with a glycine-rich conserved domain (Rossmann-fold) starting at position 247 for cosubstrate binding (GIHGFGAIGGG). The N-terminal domain of MtlD is similar to members of the HAD (haloacid dehalogenase) superfamily |
-, 729646 |
| 1.1.1.17 | evolution |
the enzyme belongs to the medium chain dehydrogenases |
722935 |
| 1.1.1.17 | malfunction |
deletion of gene mtlD results in a complete loss of salt-dependent mannitol biosynthesis |
722126 |
| 1.1.1.17 | malfunction |
the Corynebacterium glutamicum arabitol-negative DELTAmtlD deletion mutant can be complemented by heterologous expression of Bacillus methanolicus strain MGA3 operon atlABCD or gene atlD |
761143 |
| 1.1.1.17 | metabolism |
mannitol-1-phosphate dehydrogenase mediates the first step of two-step pathway for osmo-induced synthesis of mannitol, regulated by salinity on the transcriptional as well as on the activity level, overview |
722126 |
| 1.1.1.17 | metabolism |
mannitol-1-phosphate dehydrogenase MtlD is essential for mannitol biosynthesis and catalyses the first step in mannitol biosynthesis, the reduction of fructose-6-phosphate to the intermediate mannitol-1-phosphate |
-, 729646 |
| 1.1.1.17 | metabolism |
the enzyme catalyzes the first step of the synthesis of mannitol, i.e. reduction of the photo-assimilate fructose-6-phosphate, mannitol cycle, overview |
-, 723496 |
| 1.1.1.17 | metabolism |
the enzyme is involved in the arabitol catabolism and the pentose phosphate pathway, model of the pathways for arabitol catabolism in bacteria, overview |
-, 761143 |
| 1.1.1.17 | metabolism |
the enzyme is involved in the mannitol cycle in the fungus |
711878 |
