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EC 2.7.7.97 Details
EC number
2.7.7.97
Accepted name
3-hydroxy-4-methylanthranilate adenylyltransferase
Reaction
ATP + 3-hydroxy-4-methylanthranilate = diphosphate + 3-hydroxy-4-methylanthranilyl-adenylate
Other name(s)
acmA (gene name),
sibE (gene name),
actinomycin synthase I,
4-MHA-activating enzyme,
ACMS I,
actinomycin synthetase I,
4-MHA pentapeptide lactone synthase AcmA
Systematic name
ATP:3-hydroxy-4-methylanthranilate adenylyltransferase
Comment
The enzyme, characterized from the bacteria Streptomyces anulatus and Streptosporangium sibiricum, activates 3-hydroxy-4-methylanthranilate, a precursor of actinomycin antibiotics and the antitumor antibiotic sibiromycin, to an adenylate form, so it can be loaded onto a dedicated aryl-carrier protein.
History
created 2016
EC Tree
1.12.7.1 created 1972, deleted 1978
2.7.7.16 created 1961, deleted 1972, [transferred to EC 3.1.4.22, deleted 1980]
2.7.7.17 created 1965, deleted 1972, [transferred to EC 3.1.4.23, deleted 1980]
2.7.7.20 created 1965, deleted 1972
2.7.7.26 created 1961 as EC 3.1.4.8, transferred 1965 to EC 2.7.7.26, deleted 1972
2.7.7.29 created 1972, deleted 2004