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EC 2.7.7.19 Details
EC number
2.7.7.19
Accepted name
polynucleotide adenylyltransferase
Reaction
ATP + RNAn = diphosphate + RNAn+1
Other name(s)
NTP polymerase,
RNA adenylating enzyme,
AMP polynucleotidylexotransferase,
ATP-polynucleotide adenylyltransferase,
ATP:polynucleotidylexotransferase,
poly(A) polymerase,
poly(A) synthetase,
polyadenylate nucleotidyltransferase,
polyadenylate polymerase,
polyadenylate synthetase,
polyadenylic acid polymerase,
polyadenylic polymerase,
terminal riboadenylate transferase,
poly(A) hydrolase,
RNA formation factors, PF1,
adenosine triphosphate:ribonucleic acid adenylyltransferase
Systematic name
ATP:polynucleotide adenylyltransferase
CAS registry number
9026-30-6
Comment
Also acts slowly with CTP. Catalyses template-independent extension of the 3′- end of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3′-OH terminal group. See also EC 2.7.7.6 DNA-directed RNA polymerase.
History
created 1965
EC Tree
1.12.7.1 created 1972, deleted 1978
2.7.7.16 created 1961, deleted 1972, [transferred to EC 3.1.4.22, deleted 1980]
2.7.7.17 created 1965, deleted 1972, [transferred to EC 3.1.4.23, deleted 1980]
2.7.7.20 created 1965, deleted 1972
2.7.7.26 created 1961 as EC 3.1.4.8, transferred 1965 to EC 2.7.7.26, deleted 1972
2.7.7.29 created 1972, deleted 2004