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EC 1.14.14.37 Details
show Brenda entryEC number
1.14.14.37
Accepted name
4-hydroxyphenylacetaldehyde oxime monooxygenase
Reaction
(E)-4-hydroxyphenylacetaldehyde oxime + [reduced NADPH—hemoprotein reductase] + O2 = (S)-4-hydroxymandelonitrile + [oxidized NADPH—hemoprotein reductase] + 2 H2O (overall reaction);;(1a) (E)-4-hydroxyphenylacetaldehyde oxime = (Z)-4-hydroxyphenylacetaldehyde oxime;;(1b) (Z)-4-hydroxyphenylacetaldehyde oxime = 4-hydroxyphenylacetonitrile + H2O;;(1c) 4-hydroxyphenylacetonitrile + [reduced NADPH—hemoprotein reductase] + O2 = (S)-4-hydroxymandelonitrile + [oxidized NADPH—hemoprotein reductase] + H2O
Other name(s)
4-hydroxybenzeneacetaldehyde oxime monooxygenase,
cytochrome P450II-dependent monooxygenase,
NADPH-cytochrome P450 reductase (CYP71E1),
CYP71E1,
4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase
Systematic name
(E)-4-hydroxyphenylacetaldehyde oxime,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase
Comment
This cytochrome P-450 (heme thiolate) enzyme is involved in the biosynthesis of the cyanogenic glucoside dhurrin in sorghum. It catalyses three different activities - isomerization of the (E) isomer to the (Z) isomer, dehydration, and C-hydroxylation.
History
created 2000 as EC 1.14.13.68, modified 2005, transferred 2016 to EC 1.14.14.37
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.14.2 created 1972, deleted 1976 1.14.14.4 created 2000, deleted 2002
