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EC 1.14.14.143 Details
show Brenda entryEC number
1.14.14.143
Accepted name
(+)-menthofuran synthase
Reaction
(+)-pulegone + [reduced NADPH—hemoprotein reductase] + O2 = (+)-menthofuran + [oxidized NADPH—hemoprotein reductase] + H2O
Other name(s)
menthofuran synthase,
(+)-pulegone 9-hydroxylase,
(+)-MFS,
cytochrome P450 menthofuran synthase
Systematic name
(+)-pulegone,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (9-hydroxylating)
Comment
A cytochrome P-450 (heme-thiolate) protein. The conversion of substrate into product involves the hydroxylation of the syn-methyl (C9), intramolecular cyclization to the hemiketal and dehydration to the furan [1]. This is the second cytochrome P-450-mediated step of monoterpene metabolism in peppermint, with the other step being catalysed by EC 1.14.14.99, (S)-limonene 3-monooxygenase [1].
History
created 2008 as EC 1.14.13.104, transferred 2018 to EC 1.14.14.143
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.14.2 created 1972, deleted 1976 1.14.14.4 created 2000, deleted 2002
