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EC 1.3.8.9 Details
show Brenda entryEC number
1.3.8.9
Accepted name
very-long-chain acyl-CoA dehydrogenase
Reaction
a very-long-chain acyl-CoA + electron-transfer flavoprotein = a very-long-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein
Other name(s)
ACADVL (gene name).
Systematic name
very-long-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
Comment
Contains FAD as prosthetic group. One of several enzymes that catalyse the first step in fatty acids β-oxidation. The enzyme is most active toward long-chain acyl-CoAs such as C14, C16 and C18, but is also active with very-long-chain acyl-CoAs up to 24 carbons. It shows no activity for substrates of less than 12 carbons. Its specific activity towards palmitoyl-CoA is more than 10-fold that of the long-chain acyl-CoA dehydrogenase [1]. cf. EC 1.3.8.1, short-chain acyl-CoA dehydrogenase, EC 1.3.8.7, medium-chain acyl-CoA dehydrogenase, and EC 1.3.8.8, long-chain acyl-CoA dehydrogenase.
History
created 1961 as EC 1.3.2.2, transferred 1964 to EC 1.3.99.3, part transferred 2012 to EC 1.3.8.9
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.3.2.1 created 1961, deleted 1964 1.3.2.2 created 1961, deleted 1964
