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EC 1.14.11.9 Details
show Brenda entryEC number
1.14.11.9
Accepted name
flavanone 3-dioxygenase
Reaction
a (2S)-flavan-4-one + 2-oxoglutarate + O2 = a (2R,3R)-dihydroflavonol + succinate + CO2
Other name(s)
naringenin 3-hydroxylase,
flavanone 3-hydroxylase,
flavanone 3β-hydroxylase,
flavanone synthase I,
(2S)-flavanone 3-hydroxylase,
naringenin,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating),
F3H,
flavanone,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
Systematic name
(2S)-flavan-4-one,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
CAS registry number
75991-43-4
Comment
Requires Fe2+ and ascorbate. This plant enzyme catalyses an early step in the flavonoid biosynthesis pathway, leading to the production of flavanols and anthocyanins. Substrates include (2S)-naringenin, (2S)-eriodictyol, (2S)-dihydrotricetin and (2S)-pinocembrin. Some enzymes are bifuctional and also catalyse EC 1.14.20.6, flavonol synthase.
History
created 1983, modified 1989, modified 2004, modified 2016
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.4.1 created 1961, deleted 2002 1.6.4.2 created 1961, modified 1989, deleted 2002 1.6.4.3 created 1961, modified 1976, deleted 1983 1.6.4.4 created 1965, deleted 2002 1.6.4.5 created 1972, deleted 2002 1.6.4.6 created 1972, deleted 2002 1.6.4.7 created 1978, deleted 2002 1.6.4.8 created 1989, deleted 2002 1.6.4.9 created 1992, deleted 2002 1.6.4.10 created 1992, deleted 2002 1.14.11.5 created 1972, deleted 1976
