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Information on EC 1.14.20.6 - flavonol synthase

for references in articles please use BRENDA:EC1.14.20.6
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IUBMB Comments
In addition to the desaturation of (2R,3R)-dihydroflavonols to flavonols, the enzyme from Citrus unshiu (satsuma mandarin) also has a non-specific activity that trans-hydroxylates the flavanones (2S)-naringenin and the unnatural (2R)-naringenin at C-3 to kaempferol and (2R,3R)-dihydrokaempferol, respectively . Requires Fe2+.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
AaFLS1, BnFLS, Cs-COR054, Cs-COR113, FKS2, flavonoid 2-oxoglutarate-dependent dioxygenase, flavonol synthase, FLS, FLS1, FLS2, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a dihydroflavonol + 2-oxoglutarate + O2 = a flavonol + succinate + CO2 + H2O
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