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EC 3.5.99.6 Details
show Brenda entryEC number
3.5.99.6
Accepted name
glucosamine-6-phosphate deaminase
Reaction
α-D-glucosamine 6-phosphate + H2O = D-fructose 6-phosphate + NH3
Other name(s)
glucosaminephosphate isomerase (ambiguous),
glucosamine-6-phosphate isomerase (ambiguous),
phosphoglucosaminisomerase (ambiguous),
glucosamine phosphate deaminase,
aminodeoxyglucosephosphate isomerase (ambiguous),
phosphoglucosamine isomerase (ambiguous),
2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol isomerizing)
Systematic name
2-amino-2-deoxy-α-D-glucose-6-phosphate aminohydrolase (ketol isomerizing)
CAS registry number
9013-10-9
Comment
The enzyme uses ring opening and isomerization of the aldose-ketose type to convert the -CH(-NH2)-CH=O group of glucosamine 6-phosphate into -C(=NH)-CH2-OH, forming 2-deoxy-2-imino-D-arabino-hexitol, which then hydrolyses to yield fructose 6-phosphate and ammonia. N-Acetyl-D-glucosamine 6-phosphate, which is not broken down, activates the enzyme.
History
created 1961 as EC 5.3.1.10, transferred 2000 to EC 3.5.99.6
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1 Oxidoreductases
3 Hydrolases
3.5.99.1 riboflavinase
