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EC 1.14.14.26 Details
show Brenda entryEC number
1.14.14.26
Accepted name
24-hydroxycholesterol 7α-hydroxylase
Reaction
(24S)-cholest-5-ene-3β,24-diol + [reduced NADPH—hemoprotein reductase] + O2 = (24S)-cholest-5-ene-3β,7α,24-triol + [oxidized NADPH—hemoprotein reductase] + H2O
Other name(s)
24-hydroxycholesterol 7α-monooxygenase,
CYP39A1,
CYP39A1 oxysterol 7α-hydroxylase
Systematic name
(24S)-cholest-5-ene-3β,24-diol,NADPH—hemoprotein reductase:oxygen oxidoreductase (7α-hydroxylating)
CAS registry number
288309-90-0
Comment
A P-450 heme-thiolate protein that is found in liver microsomes and in ciliary non-pigmented epithelium [2]. The enzyme is specific for (24S)-cholest-5-ene-3β,24-diol, which is formed mostly in the brain by EC 1.14.14.25, cholesterol 24-hydroxylase. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH—hemoprotein reductase.
History
created 2005 as EC 1.14.13.99, transferred 2016 to EC 1.14.14.26
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.14.2 created 1972, deleted 1976 1.14.14.4 created 2000, deleted 2002
