EC Explorer
[browse EC tree] - [search]
EC 1.14.14.131 Details
show Brenda entryEC number
1.14.14.131
Accepted name
bursehernin 5′-monooxygenase
Reaction
(–)-bursehernin + [reduced NADPH—hemoprotein reductase] + O2 = (–)-5′-demethylyatein + [oxidized NADPH—hemoprotein reductase] + H2O
Other name(s)
CYP71CU1 (gene name),
bursehernin 5′-hydroxylase
Systematic name
(–)-bursehernin,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (5′-hydroxylating)
Comment
A cytochrome P-450 (heme-thiolate) protein characterized from the plant Sinopodophyllum hexandrum. The enzyme is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs.
History
created 2016 as EC 1.14.13.213, transferred 2018 to EC 1.14.14.131
back to topEC Tree
1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.14.2 created 1972, deleted 1976 1.14.14.4 created 2000, deleted 2002
