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EC 1.14.14.22 Details
show Brenda entryEC number
1.14.14.22
Accepted name
dibenzothiophene sulfone monooxygenase
Reaction
dibenzothiophene-5,5-dioxide + FMNH2 + NADH + O2 = 2′-hydroxybiphenyl-2-sulfinate + H2O + FMN + NAD+ + H+ (overall reaction);;(1a) FMNH2 + O2 = FMN-N5-peroxide;;(1b) dibenzothiophene-5,5-dioxide + FMN-N5-peroxide = 2′-hydroxybiphenyl-2-sulfinate + FMN-N5-oxide;;(1c) FMN-N5-oxide + NADH = FMN + H2O + NAD+ + H+ (spontaneous)
Other name(s)
dszA (gene name)
Systematic name
dibenzothiophene-5,5-dioxide,FMNH2:oxygen oxidoreductase
Comment
This bacterial enzyme catalyses a step in the desulfurization pathway of dibenzothiophenes. The enzyme forms a two-component system with a dedicated NADH-dependent FMN reductase (EC 1.5.1.42) encoded by the dszD gene, which also interacts with EC 1.14.14.21, dibenzothiophene monooxygenase. The flavin-N5-oxide that is formed by the enzyme reacts spontaneously with NADH to give oxidized flavin, releasing a water molecule.
History
created 2016, modified 2019
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.14.2 created 1972, deleted 1976 1.14.14.4 created 2000, deleted 2002
