4.3.1.19: threonine ammonia-lyase

This is an abbreviated version!
For detailed information about threonine ammonia-lyase, go to the full flat file.

Reaction

Synonyms

BsBTD1, CgBTD1, CgCTD, EC 4.2.1.16, EcBTD2, EcCTD, FgIlv1, GSU0486, ilvA, L-TD, L-TDH, L-threonine deaminase, L-threonine dehydratase, MSMEG3183, OMR1, PpBTD2, pTD2, SaBTD1, SaCTD, SgBTD1, SlTD1, SlTD2, sp0454, TD, TD1, TD2, tdcB, TDH, TH, Thr ammonia-lyase, threonine ammonia-lyase, Threonine deaminase, threonine deaminase/dehydratase, threonine dehydrase, threonine dehydratase, threonine dehydratase/deaminase

ECTree

     4 Lyases

         4.3 Carbon-nitrogen lyases

             4.3.1 Ammonia-lyases

                4.3.1.19 threonine ammonia-lyase

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Results	in table
32	Activating Compound
36525	AA Sequence
3	Application
1	CAS Registry Number
25	Cloned(Commentary)
44	Cofactor
4	Crystallization (Commentary)
4	Expression
12	General Information
3	General Stability
8	IC50 Value
155	Inhibitors
6	kcat/KM [mM/s]
4	Ki Value [mM]
72	KM Value [mM]
3	Localization
17	Metals/Ions
65	Molecular Weight [Da]
34	Natural Substrates/ Products (Substrates)
150	Organism
9	Pathway
14	PDB ID
36	pH Optimum
7	pH Range
1	pI Value
41	Protein Variants
38	Purification (Commentary)
6	Reaction
9	Reaction Type
119	Reference
20	Source Tissue
48	Specific Activity [micromol/min/mg]
8	Storage Stability
171	Substrates and Products (Substrate)
31	Subunits
84	Synonyms
1	Systematic Name
17	Temperature Optimum [°C]
3	Temperature Range [°C]
28	Temperature Stability [°C]
21	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 4.3.1.19 - threonine ammonia-lyase

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SYSTEMATIC NAME

IUBMB Comments

L-threonine ammonia-lyase (2-oxobutanoate-forming)

Most enzymes that catalyse this reaction are pyridoxal-phosphate-dependent, although some enzymes contain an iron-sulfur cluster instead. The reaction catalysed by both types of enzymes involves the initial elimination of water to form an enamine intermediate (hence the enzyme's original classification as EC 4.2.1.16, threonine dehydratase), followed by tautomerization to an imine form and hydrolysis of the C-N bond [3,5]. The latter reaction, which can occur spontaneously, is also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase [5]. The enzymes from a number of sources also act on L-serine, cf. EC 4.3.1.17, L-serine ammonia-lyase.