4.3.1.19: threonine ammonia-lyase
This is an abbreviated version!
For detailed information about threonine ammonia-lyase, go to the full flat file.
Word Map on EC 4.3.1.19
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4.3.1.19
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valine
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pyridoxal
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l-isoleucine
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4.2.1.16
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alpha-ketobutyrate
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2-ketobutyrate
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l-serine
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homoserine
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isoleucine-valine
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acetohydroxy
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acetolactate
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citramalate
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attenuata
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feedback-resistant
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2-oxobutyrate
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acetohydroxyacid
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sinoatrial
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molecular biology
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synthesis
- 4.3.1.19
- valine
- pyridoxal
- l-isoleucine
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4.2.1.16
- alpha-ketobutyrate
- 2-ketobutyrate
- l-serine
- homoserine
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isoleucine-valine
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acetohydroxy
- acetolactate
- citramalate
- attenuata
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feedback-resistant
- 2-oxobutyrate
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acetohydroxyacid
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sinoatrial
- molecular biology
- synthesis
Reaction
Synonyms
BsBTD1, CgBTD1, CgCTD, EC 4.2.1.16, EcBTD2, EcCTD, FgIlv1, GSU0486, ilvA, L-TD, L-TDH, L-threonine deaminase, L-threonine dehydratase, MSMEG3183, OMR1, PpBTD2, pTD2, SaBTD1, SaCTD, SgBTD1, SlTD1, SlTD2, sp0454, TD, TD1, TD2, tdcB, TDH, TH, Thr ammonia-lyase, threonine ammonia-lyase, Threonine deaminase, threonine deaminase/dehydratase, threonine dehydrase, threonine dehydratase, threonine dehydratase/deaminase
ECTree
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Substrates Products
Substrates Products on EC 4.3.1.19 - threonine ammonia-lyase
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REACTION DIAGRAM
beta-chloro-L-alanine
3-chloro-2-oxopropionate + NH3
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L-serine
pyruvate + NH3
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dehydratase I: 26% of the activity with L-Thr, dehydratase II: 16% of the activity with L-Thr
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L-serine
pyruvate + NH3
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dehydratase I: 26% of the activity with L-Thr, dehydratase II: 16% of the activity with L-Thr
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L-Thr
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isoleucine-insensitive enzyme is subject to glucose-mediated catabolite repression
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L-Thr
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isoleucine-insensitive enzyme is subject to glucose-mediated catabolite repression
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L-Thr
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the enzyme is an important element in the flux control of Ile biosynthesis
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L-Thr
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increase of activity under gluconeogenic conditions in adult-rat hepatocytes cultured on collagen gel/nylon mesh
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L-Thr
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the enzyme is formed under anaerobic conditions, the enzyme is induced by L-Ser and L-Thr, cAMP is required for the synthesis of the enzyme
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L-threonine
2-oxobutanoate + NH3
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threonine deaminase is a key regulatory enzyme in the pathway for the biosynthesis of isoleucine, allosteric enzyme regulation model, overview
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L-threonine
2-oxobutanoate + NH3
the enzyme catalyzes the first step in the biosynthesis pathway of isoleucine for conversion of threonine to 2-oxobutanoate
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L-threonine
2-oxobutanoate + NH3
the enzyme catalyzes the first step in the biosynthesis pathway of isoleucine for conversion of threonine to 2-oxobutanoate
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L-threonine
2-oxobutanoate + NH3
a step in the pathway for the biosynthesis of isoleucine via isoleucine precursor 2-oxobutanoate generated from threonine, this pathway accounts for a minor fraction of isoleucine biosynthesis, while the majority of isoleucine is instead derived from acetyl-coenzyme A and pyruvate, possibly via the citramalate pathway, overview
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L-threonine
2-oxobutanoate + NH3
a step in the pathway for the biosynthesis of isoleucine via isoleucine precursor 2-oxobutanoate generated from threonine, this pathway accounts for a minor fraction of isoleucine biosynthesis, while the majority of isoleucine is instead derived from acetyl-coenzyme A and pyruvate, possibly via the citramalate pathway, overview
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L-threonine
2-oxobutanoate + NH3
the enzyme is involved in the biosynthesis of L-isoleucine
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L-threonine
2-oxobutanoate + NH3
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biodegradation of L-threonine, the enzyme is involved in the biosynthetis pathway for isoleucine production, which is competitng with the valine biosynthetic pathway for the second precursor pyruvate
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?
L-threonine
2-oxobutanoate + NH3
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biodegradation of L-threonine, the enzyme is involved in the biosynthetis pathway for isoleucine production, which is competitng with the valine biosynthetic pathway for the second precursor pyruvate
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?
L-threonine
2-oxobutanoate + NH3
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L-threonine
2-oxobutanoate + NH3
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L-threonine
2-oxobutanoate + NH3
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L-threonine
2-oxobutanoate + NH3
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GSU0486 also catalyzes the deamination of L-serine, EC 4.3.1.17
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additional information
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GSU0486 also catalyzes the deamination of L-serine, EC 4.3.1.17
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additional information
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GSU0486 also catalyzes the deamination of L-serine, EC 4.3.1.17
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additional information
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when pyridoxamine 5'-phosphate is incubated with the apoenzyme in the presence of small quantities of keto acids, e.g. pyruvate or 2-oxobutanoate, small amounts of L-Ala or L-aminobutanoate are formed, the reaction is not reversible
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