4.2.1.51: prephenate dehydratase

This is an abbreviated version!
For detailed information about prephenate dehydratase, go to the full flat file.

Reaction

Synonyms

ADT1, ADT2, ADT6, AroQ, chorismate mutase prephenate dehydratase, chorismate mutase-prephenate dehydratase, Chorismate mutase/prephenate dehydratase, CM-PD, CM/PDT/PDHG, Cmut1, CM�PDT, Ct-PDT, cyclohexydienyl dehydratase, dehydratase, prephenate, Gmut11, Gmut9, MjPDT, monofunctional prephenate dehydratase, MtbPDT, P-protein, P-protein dehydratase, PDT, PDT protein, PheA, PpADT-B, PpADT-C, PpADT-G, prephenate dehydratase, prephenate dehydratase 1, Sa-PDT

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.1 Hydro-lyases

                4.2.1.51 prephenate dehydratase

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Results	in table
40	Activating Compound
37529	AA Sequence
5	Application
1	CAS Registry Number
23	Cloned(Commentary)
5	Crystallization (Commentary)
1	Expression
11	General Information
2	General Stability
2	IC50 Value
65	Inhibitors
7	kcat/KM [mM/s]
7	Ki Value [mM]
47	KM Value [mM]
3	Localization
2	Metals/Ions
43	Molecular Weight [Da]
48	Natural Substrates/ Products (Substrates)
284	Organism
7	Pathway
18	PDB ID
11	pH Optimum
3	pH Range
1	pH Stability
42	Protein Variants
23	Purification (Commentary)
5	Reaction
3	Reaction Type
65	Reference
3	Source Tissue
34	Specific Activity [micromol/min/mg]
8	Storage Stability
103	Substrates and Products (Substrate)
32	Subunits
54	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
4	Temperature Stability [°C]
26	Turnover Number [1/s]

KM Value

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KM Value on EC 4.2.1.51 - prephenate dehydratase

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.12 - 0.17

L-arogenate

2 entries

1.3 - 4.88

phenylpyruvate

3 entries

0.01 - 4.88

prephenate

41 entries

additional information

additional information

Escherichia coli

-

Km for chorismate of wild-type and mutants

649980

-

0.12

L-arogenate

Oryza sativa

A8CF65, Q6Z3Y3

wild-type, rice PDT is a bifunctional enzyme

694629

0.17

L-arogenate

Oryza sativa

A8CF65, Q6Z3Y3

mutant S298I, rice PDT is a bifunctional enzyme

694629

1.3

phenylpyruvate

Archaeoglobus fulgidus

O30012

measuring the appearance of phenylpyruvate at 320 nm, performed with 1 mM prephenate in 200 mM Tris buffer

692260

2.29

phenylpyruvate

Oryza sativa

A8CF65, Q6Z3Y3

wild-type

694629

4.88

phenylpyruvate

Oryza sativa

A8CF65, Q6Z3Y3

Mtr1 mutant

694629

0.01

prephenate

Sphingomonas paucimobilis

-

presence of 1 mM L-Trp

33879

0.015

prephenate

Sphingomonas paucimobilis

-

presence of 1 mM L-Tyr

33879

0.017

prephenate

Sphingomonas paucimobilis

-

presence of 1 mM L-Phe

33879

0.02

prephenate

Pseudomonas sp.

-

presence of L-Tyr

33890

0.022

prephenate

Methanocaldococcus jannaschii

-

30°C

678167

0.07

prephenate

Corynebacterium glutamicum

-

wild-type enzyme, pH 7.5, 30°C

649516

0.08

prephenate

Corynebacterium glutamicum

-

mutant S99T, pH 7.5, 30°C

649516

0.09

prephenate

Corynebacterium glutamicum

-

mutant S99C, pH 7.5, 30°C

649516

0.1

prephenate

Corynebacterium glutamicum

-

-

33885

0.12

prephenate

Escherichia coli

-

mutant E159A/E232A, 37°C

649980

0.13

prephenate

Corynebacterium glutamicum

-

mutant S99A, pH 7.5, 30°C

649516

0.15

prephenate

Pinus pinaster

A0A1I9WKA1, A0A1I9WKA2, A0A1I9WKA6

pH 8.0, 37°C

748952

0.16

prephenate

Escherichia coli

-

mutant E232A, 37°C

649980

0.17

prephenate

Pantoea agglomerans

-

-

33892

0.18

prephenate

Corynebacterium glutamicum

-

mutant S99M, pH 7.5, 30°C

649516

0.25

prephenate

Escherichia coli

-

mutant E159A, 37°C

649980

0.29

prephenate

Corynebacterium glutamicum

-

mutant E164D, pH 7.5, 30°C

649516

0.3

prephenate

Pinus pinaster

A0A1I9WKA1, A0A1I9WKA2, A0A1I9WKA6

pH 8.0, 37°C, prephenate dehydratase Cmut1

748952

0.33

prephenate

Candida maltosa

-

-

33876

0.34

prephenate

Pinus pinaster

A0A1I9WKA1, A0A1I9WKA2, A0A1I9WKA6

pH 8.0, 37°C

748952

0.46

prephenate

Corynebacterium glutamicum

-

mutant T183S, pH 7.5, 30°C

649516

0.47 - 1

prephenate

Escherichia coli

-

-

3574

0.5

prephenate

Mycobacterium tuberculosis

-

-

665625

0.56

prephenate

Escherichia coli

-

native P-protein, 37°C

649980

0.57

prephenate

Escherichia coli

-

mutant T278S, 37°C

649980

0.61

prephenate

Corynebacterium glutamicum

-

mutant R184L, pH 7.5, 30°C

649516

0.65

prephenate

Escherichia coli

-

recombinant prephenate dehydratase domain, 37°C

649980

0.67

prephenate

Cupriavidus necator

-

-

33883

1

prephenate

Escherichia coli

-

-

33886

1.2

prephenate

Pseudomonas sp.

-

absence of L-Tyr

33890

1.2

prephenate

Methanococcus maripaludis

-

pH and temperature not specified in the publication

727742

1.3

prephenate

Archaeoglobus fulgidus

O30012

77°C, pH not specified in the publication

692260

1.65

prephenate

Escherichia coli

-

mutant N160A, 37°C

649980

1.73

prephenate

Corynebacterium glutamicum

-

mutant F185Y, pH 7.5, 30°C

649516

2.09

prephenate

Escherichia coli

-

mutant C216S, 37°C

649980

2.11

prephenate

Pinus pinaster

A0A1I9WKA1, A0A1I9WKA2, A0A1I9WKA6

pH 8.0, 37°C, prephenate dehydratase Gmut11

748952

2.15

prephenate

Pinus pinaster

A0A1I9WKA1, A0A1I9WKA2, A0A1I9WKA6

pH 8.0, 37°C, prephenate dehydratase Gmut9

748952

2.29

prephenate

Oryza sativa

A8CF65, Q6Z3Y3

wild-type, rice PDT is a bifunctional enzyme

694629

2.72

prephenate

Pinus pinaster

A0A1I9WKA1, A0A1I9WKA2, A0A1I9WKA6

pH 8.0, 37°C

748952

3

prephenate

Escherichia coli

-

above, mutant W226L, 37°C

649980

4.88

prephenate

Oryza sativa

A8CF65, Q6Z3Y3

mutant S298I, rice PDT is a bifunctional enzyme

694629