4.2.1.51: prephenate dehydratase
This is an abbreviated version!
For detailed information about prephenate dehydratase, go to the full flat file.
Word Map on EC 4.2.1.51
-
4.2.1.51
-
l-phenylalanine
-
arogenate
-
l-tyrosine
-
dahp
-
l-phe
-
7-phosphate
-
cyclohexadienyl
-
l-tyr
-
3-deoxy-d-arabino-heptulosonate
-
feedback-inhibited
-
5.4.99.5
-
synthesis
-
industry
- 4.2.1.51
- l-phenylalanine
- arogenate
- l-tyrosine
- dahp
- l-phe
- 7-phosphate
-
cyclohexadienyl
- l-tyr
-
3-deoxy-d-arabino-heptulosonate
-
feedback-inhibited
-
5.4.99.5
- synthesis
- industry
Reaction
Synonyms
ADT1, ADT2, ADT6, AroQ, chorismate mutase prephenate dehydratase, chorismate mutase-prephenate dehydratase, Chorismate mutase/prephenate dehydratase, CM-PD, CM/PDT/PDHG, Cmut1, CM–PDT, Ct-PDT, cyclohexydienyl dehydratase, dehydratase, prephenate, Gmut11, Gmut9, MjPDT, monofunctional prephenate dehydratase, MtbPDT, P-protein, P-protein dehydratase, PDT, PDT protein, PheA, PpADT-B, PpADT-C, PpADT-G, prephenate dehydratase, prephenate dehydratase 1, Sa-PDT
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Reference on EC 4.2.1.51 - prephenate dehydratase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Friedrich, B.; Friedrich, C.G.; Schlegel, H.G.
Purification and properties of chorismate mutase-prephenate dehydratase and prephenate dehydrogenase from Alcaligenes eutrophus
J. Bacteriol.
126
712-722
1976
Cupriavidus necator
Gething, M.J.; Davidson, B.E.; Dopheide, T.A.A.
Chorismate mutase/prephenate dehydratase from Escherichia coli K12. 1. The effect of NaCl and its use in a new purification involving affinity chromatography on sepharosyl-phenylalanine
Eur. J. Biochem.
71
317-325
1976
Escherichia coli
Stewart, J.; Wilson, D.B.; Ganem, B.
Chorismate mutase/prephenate dehydratase from Escherichia coli: subcloning, overproduction and purification
Tetrahedron
47
2573-2577
1991
Escherichia coli
-
Ahmad, S.; Wilson, A.T.; Jensen, R.A.
Chorismate mutase: prephenate dehydratase from Acinetobacter calcoaceticus. Purification, properties and immunological cross-reactivity
Eur. J. Biochem.
176
69-79
1988
Acinetobacter calcoaceticus
Zhang, S.; Pohnert, G.; Kongsaeree, P.; Wilson, D.B.; Clardy, J.; Ganem, B.
Chorismate mutase-prephenate dehydratase from Escherichia coli. Study of catalytic and regulatory domains using genetically engineered proteins
J. Biol. Chem.
273
6248-6253
1998
Escherichia coli
Davidson, B.E.
Chorismate mutase-prephenate dehydratase from Escherichia coli
Methods Enzymol.
142
432-439
1987
Escherichia coli
Bertaux, S.; Harrison, R.G.
Purification of prephenate dehydratase from Corynebacterium glutamicum by affinity chromatography
Prep. Biochem.
21
269-275
1991
Corynebacterium glutamicum
Jensen, R.A.; d'Amato, T.A.; Hochstein, L.I.
An extreme-halophile archaebacterium possesses the interlock type or prephenate dehydratase characteristic of gram-positive eubacteria
Arch. Microbiol.
148
365-371
1988
Haloarcula vallismortis
Fischer, R.; Jensen, R.
Prephenate dehydratase (monofunctional)
Methods Enzymol.
142
507-512
1987
Bacillus subtilis
Follettie, M.T.; Sinskey, A.J.
Molecular cloning and nucleotide sequence of the Corynebacterium glutamicum pheA gene
J. Bacteriol.
167
695-702
1986
Corynebacterium glutamicum
Ozaki, A.; Katsumata, R.; Oka, T.; Furuya, A.
Cloning of the genes concerend in phenylalanine biosynthesis in Corynebacterium glutamicum and its application to breeding of a phenylalanine producing strain
Agric. Biol. Chem.
49
2925-2930
1985
Corynebacterium glutamicum
-
Bode, R.; Melo, C.; Birnbaum, D.
Regulation of chorismate mutase, prephenate dehydrogenase and prephenate dehydratase of Candida maltosa
J. Basic Microbiol.
25
291-298
1985
Candida maltosa
-
Baldwin, G.S.; Davidson, B.E.
Kinetic studies on the mechanism of chorismate mutase/prephenate dehydratase from Escherichia coli K12
Biochim. Biophys. Acta
742
374-383
1983
Escherichia coli
Baldwin, G.S.; McKenzie, G.H.; Davidson, B.E.
The self-association of chorismate mutase/prephenate dehydratase from Escherichia coli K12
Arch. Biochem. Biophys.
211
76-85
1981
Escherichia coli
Krauss, G.; Suessmuth, R.; Lingens, F.
[A prephenate dehydratase from Flavobacterium devorans stimulated by aromatic amino acids (author s transl)
Hoppe-Seyler's Z. Physiol. Chem.
361
809-818
1980
Sphingomonas paucimobilis
Riepl, R.G.; Glover, G.I.
Regulation and state of aggregation of Bacillus subtilis prephenate dehydratase in the presence of allosteric effectors
J. Biol. Chem.
254
10321-10328
1979
Bacillus subtilis
Riepl, R.G.; Glover, G.I.
Purification of Prephenate dehydratase from Bacillus subtilis
Arch. Biochem. Biophys.
191
192-197
1978
Bacillus subtilis
Friedrich, C.G.; Friedrich, B.; Schlegel, H.G.
Regulation of Chorismate mutase-prephenate dehydratase and prephenate dehydrogenase from alcaligenes eutrophus
J. Bacteriol.
126
723-732
1976
Cupriavidus necator
Hagino, H.; Nakayama, K.
Regulatory properties of prephenate dehydrogenase and prephenate dehydratase from Corynebacterium glutamicum
Agric. Biol. Chem.
38
2367-2376
1974
Corynebacterium glutamicum
-
Dopheide, T.A.A.; Crewther, P.; Davidson, B.E.
Chorismate mutase-prephenate dehydratase from Escherichia coli K-12. II. Kinetic properties
J. Biol. Chem.
247
4447-4452
1972
Escherichia coli
Davidson, B.E.; Blackburn, E.H.; Dopheide, T.A.A.
Chorismate mutase-prephenate dehydratase from Escherichia coli K-12. I. Purification, molecular weight, and amino acid composition
J. Biol. Chem.
247
4441-4446
1972
Escherichia coli
Schmit, J.C.; Artz, S.W.; Zalkin, H.
Chorismate mutase-prephenate dehydratase. Evidence for distinct catalytic and regulatory sites
J. Biol. Chem.
245
4019-4027
1970
Salmonella enterica subsp. enterica serovar Typhimurium
Schmit, J.C.; Zalkin, H.
Chorismate mutase-prephenate dehydratase. Partial purification and properties of the enzyme from Salmonella typhimurium
Biochemistry
8
174-181
1969
Salmonella enterica subsp. enterica serovar Typhimurium
Cerutti, P.; Guroff, G.
Enzymatic formation of phenylpyruvic acid in Pseudomonas sp. (ATCC11299a) and its regulation
J. Biol. Chem.
240
3034-3038
1965
Pseudomonas sp.
Bushweller, J.H.; Bartlett, P.A.
Sulfoxide analogues of dihydro- and tetrahydroprephenate as inhibitors of prephenate dehydratase
J. Org. Chem.
54
2404-2409
1989
Escherichia coli
-
Xia, T.; Ahmad, S.; Zhao, G.; Jensen, R.A.
A single cyclohexadienyl dehydratase specifies the prephenate dehydratase and arogenate dehydratase components of one of two independent pathways to L-phenylalanine in Erwinia herbicola
Arch. Biochem. Biophys.
286
461-465
1991
Pantoea agglomerans
Nelms, J.; Edwards, R.M.; Warwick, J.; Fotheringham, I.
Novel mutations in the pheA gene of Escherichia coli K-12 which result in highly feedback inhibition-resistant variants of chorismate mutase/prephenate dehydratase
Appl. Environ. Microbiol.
58
2592-2598
1992
Escherichia coli
Ikeda, M.; Ozaki, A.; Katsumata, R.
Phenylalanine production by metabolically engineered Corynebacterium glutamicum with the pheA gene of Escherichia coli
Appl. Microbiol. Biotechnol.
39
318-323
1993
Escherichia coli
Vrijbloed, J.W.; Hylckama Vlieg, J.; Put, J.; Hessels, G.I.; Dijkhuizen, L.
Molecular cloning with a pMEA300-derived shuttle vector and characterization of the Amycolatopsis methanolica prephenate dehydratase gene
J. Bacteriol.
177
6666-6669
1995
Amycolatopsis methanolica
Euverink, G.J.W.; Wolters, D.J.; Dijkhuizen, L.
Prephenate dehydratase of the actinomycete Amycolatopsis methanolica: purification and characterization of wild-type and deregulated mutant proteins
Biochem. J.
308
313-320
1995
Amycolatopsis methanolica
Chan, M.S.; Hsu, W.H.
Cloning of m-fluorophenylalanine-resistant gene and mutational analysis of feedback-resistant prephenate dehydratase from Corynebacterium glutamicum
Biochem. Biophys. Res. Commun.
219
537-542
1996
Corynebacterium glutamicum
Fischer, R.S.; Zhao, G.; Jemsen, R.A.
Cloning, sequencing, and expression of the P-protein gene (pheA) of Pseudomonas stutzeri in Escherichia coli: implications for evolutionary relationships in phenylalanine biosynthesis
J. Gen. Microbiol.
137
1293-1301
1991
Pseudomonas stutzeri
Hsu, S.K.; Lin, L.L.; Lo, H.H.; Hsu, W.H.
Mutational analysis of feedback inhibition and catalytic sites of prephenate dehydratase from Corynebacterium glutamicum
Arch. Microbiol.
181
237-244
2004
Corynebacterium glutamicum, Corynebacterium glutamicum CCRC 11384
Zhang, S.; Wilson, D.B.; Ganem, B.
Probing the catalytic mechanism of prephenate dehydratase by site-directed mutagenesis of the Escherichia coli P-protein dehydratase domain
Biochemistry
39
4722-4728
2000
Escherichia coli
Jimenez, N.; Gonzalez-Candelas, F.; Silva, F.J.
Prephenate dehydratase from the aphid endosymbiont (Buchnera) displays changes in the regulatory domain that suggest its desensitization to inhibition by phenylalanine
J. Bacteriol.
182
2967-2969
2000
Buchnera aphidicola (P57472), Buchnera aphidicola
Liberles, J.S.; Thorolfsson, M.; Martinez, A.
Allosteric mechanisms in ACT domain containing enzymes involved in amino acid metabolism
Amino Acids
28
1-12
2005
Escherichia coli
Prakash, P.; Pathak, N.; Hasnain, S.E.
pheA (Rv3838c) of Mycobacterium tuberculosis encodes an allosterically regulated monofunctional prephenate dehydratase that requires both catalytic and regulatory domains for optimum activity
J. Biol. Chem.
280
20666-20671
2005
Mycobacterium tuberculosis
Vivan, A.L.; Dias, M.V.; Schneider, C.Z.; Filgueira De Azevedo, W.J.; Basso, L.A.; Santos, D.S.
Crystallization and preliminary X-ray diffraction analysis of prephenate dehydratase from Mycobacterium tuberculosis H37Rv
Acta Crystallogr. Sect. F
62
357-360
2006
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Kleeb, A.C.; Kast, P.; Hilvert, D.
A monofunctional and thermostable prephenate dehydratase from the archaeon Methanocaldococcus jannaschii
Biochemistry
45
14101-14110
2006
Methanocaldococcus jannaschii
Tan, K.; Li, H.; Zhang, R.; Gu, M.; Clancy, S.T.; Joachimiak, A.
Structures of open (R) and close (T) states of prephenate dehydratase (PDT)-implication of allosteric regulation by L-phenylalanine
J. Struct. Biol.
162
94-107
2007
Chlorobaculum tepidum, Staphylococcus aureus
Warpeha, K.M.; Lateef, S.S.; Lapik, Y.; Anderson, M.; Lee, B.S.; Kaufman, L.S.
G-protein-coupled receptor 1, G-protein Galpha-subunit 1, and prephenate dehydratase 1 are required for blue light-induced production of phenylalanine in etiolated Arabidopsis
Plant Physiol.
140
844-855
2006
Arabidopsis thaliana (Q9ZUY3)
Chavez-Bejar, M.I.; Lara, A.R.; Lopez, H.; Hernandez-Chavez, G.; Martinez, A.; Ramirez, O.T.; Bolivar, F.; Gosset, G.
Metabolic engineering of Escherichia coli for L-tyrosine production by expression of genes coding for the chorismate mutase domain of the native chorismate mutase-prephenate dehydratase and a cyclohexadienyl dehydrogenase from Zymomonas mobilis
Appl. Environ. Microbiol.
74
3284-3290
2008
Zymomonas mobilis (Q5NLV8), Zymomonas mobilis, Zymomonas mobilis ATCC 31821 (Q5NLV8)
Lim, S.; Springstead, J.R.; Yu, M.; Bartkowski, W.; Schroeder, I.; Monbouquette, H.G.
Characterization of a key trifunctional enzyme for aromatic amino acid biosynthesis in Archaeoglobus fulgidus
Extremophiles
13
191-198
2009
Archaeoglobus fulgidus (O30012), Archaeoglobus fulgidus, Nanoarchaeum equitans (Q74NC4), Nanoarchaeum equitans
Yamada, T.; Matsuda, F.; Kasai, K.; Fukuoka, S.; Kitamura, K.; Tozawa, Y.; Miyagawa, H.; Wakasa, K.
Mutation of a rice gene encoding a phenylalanine biosynthetic enzyme results in accumulation of phenylalanine and tryptophan
Plant Cell
20
1316-1329
2008
Oryza sativa (A8CF65), Oryza sativa (Q6Z3Y3), Oryza sativa
Vivan, A.L.; Caceres, R.A.; Abrego, J.R.; Borges, J.C.; Ruggiero Neto, J.; Ramos, C.H.; de Azevedo, W.F.; Basso, L.A.; Santos, D.S.
Structural studies of prephenate dehydratase from Mycobacterium tuberculosis H37Rv by SAXS, ultracentrifugation, and computational analysis
Proteins
72
1352-1362
2008
Mycobacterium tuberculosis (P9WIC3), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WIC3), Mycobacterium tuberculosis H37Rv
Van Vleet, J.; Kleeb, A.; Kast, P.; Hilvert, D.; Cleland, W.W.
13C isotope effect on the reaction catalyzed by prephenate dehydratase
Biochim. Biophys. Acta
1804
752-754
2010
Methanocaldococcus jannaschii
Zhou, H.; Liao, X.; Wang, T.; Du, G.; Chen, J.
Enhanced l-phenylalanine biosynthesis by co-expression of pheA(fbr) and aroF(wt)
Biores. Technol.
101
4151-4156
2010
Escherichia coli (C7EXK8), Escherichia coli, Escherichia coli K06 (C7EXK8)
Tzin, V.; Malitsky, S.; Aharoni, A.; Galili, G.
Expression of a bacterial bi-functional chorismate mutase/prephenate dehydratase modulates primary and secondary metabolism associated with aromatic amino acids in Arabidopsis
Plant J.
60
156-167
2009
Escherichia coli
Battilana, J.; Costantini, L.; Emanuelli, F.; Sevini, F.; Segala, C.; Moser, S.; Velasco, R.; Versini, G.; Stella Grando, M.
The 1-deoxy-D: -xylulose 5-phosphate synthase gene co-localizes with a major QTL affecting monoterpene content in grapevine
Theor. Appl. Genet.
118
653-669
2009
Vitis vinifera x Vitis vinifera, Vitis vinifera x Vitis riparia
Sharma, V.; Joshi, R.; Gulati, A.
Seasonal clonal variations and effects of stresses on quality chemicals and prephenate dehydratase enzyme activity in tea (Camellia sinensis)
Eur. Food Res. Technol.
232
307-317
2011
Camellia sinensis
Bross, C.D.; Corea, O.R.; Kaldis, A.; Menassa, R.; Bernards, M.A.; Kohalmi, S.E.
Complementation of the pha2 yeast mutant suggests functional differences for arogenate dehydratases from Arabidopsis thaliana
Plant Physiol. Biochem.
49
882-890
2011
Arabidopsis thaliana
Porat, I.; Waters, B.W.; Teng, Q.; Whitman, W.B.
Two biosynthetic pathways for aromatic amino acids in the archaeon Methanococcus maripaludis
J. Bacteriol.
186
4940-4950
2004
Methanococcus maripaludis
Shin, M.H.; Ku, H.K.; Song, J.S.; Choi, S.; Son, S.Y.; Kim, H.D.; Kim, S.K.; Park, I.Y.; Lee, S.J.
X-ray structure of prephenate dehydratase from Streptococcus mutans
J. Microbiol.
52
490-495
2014
Streptococcus mutans (Q8DUV6), Streptococcus mutans
Liu, S.; Xiao, M.; Zhang, L.; Xu, J.; Ding, Z.; Gu, Z.; Shi, G.
Production of L-phenylalanine from glucose by metabolic engineering of wild type Escherichia coli W3110
Process Biochem.
48
413-419
2013
Escherichia coli, Escherichia coli W3110 / ATCC 27325
-
Wu, W.B.; Guo, X.L.; Zhang, M.L.; Huang, Q.G.; Qi, F.; Huang, J.Z.
Enhancement of L-phenylalanine production in Escherichia coli by heterologous expression of Vitreoscilla hemoglobin
Biotechnol. Appl. Biochem.
65
476-483
2018
Escherichia coli (C7EXK8)
El-Azaz, J.; de la Torre, F.; Avila, C.; Canovas, F.M.
Identification of a small protein domain present in all plant lineages that confers high prephenate dehydratase activity
Plant J.
87
215-229
2016
Pinus pinaster, Pinus pinaster (A0A1I9WKA1), Pinus pinaster (A0A1I9WKA2), Pinus pinaster (A0A1I9WKA6)
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