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4.2.1.51: prephenate dehydratase

This is an abbreviated version!
For detailed information about prephenate dehydratase, go to the full flat file.

Word Map on EC 4.2.1.51

Reaction

prephenate
=
phenylpyruvate
+
H2O
+
CO2

Synonyms

Chorismate mutase/prephenate dehydratase, dehydratase, prephenate, monofunctional prephenate dehydratase, P-protein, cyclohexydienyl dehydratase, CM-PD, PDT, P-protein dehydratase, PheA, prephenate dehydratase, MjPDT, Sa-PDT, Ct-PDT, prephenate dehydratase 1, ADT1, ADT2, ADT6, chorismate mutase-prephenate dehydratase, PDT protein, MtbPDT, chorismate mutase prephenate dehydratase, CM–PDT, AroQ, CM/PDT/PDHG, PpADT-B, PpADT-C, PpADT-G, Cmut1, Gmut9, Gmut11

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.51 prephenate dehydratase

Inhibitors

Inhibitors on EC 4.2.1.51 - prephenate dehydratase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-methyl-DL-tyrosine
-
1 mM, 23% inhibition
3-phenylpropanoate
-
-
4-methyltryptophan
-
-
5,5'-dithiobis(2-nitrobenzoate)
-
-
5-Fluorotryptophan
-
-
5-Methyltryptophan
-
-
6-Fluorotryptophan
-
-
alpha-oxo-1-carboxy-4-tetrahydrothiopyranpropanoic acid S-oxide
-
-
alpha-oxo-1-carboxy-5,6-dihydrothiopyranpropanoic acid S-oxide
-
-
cis-aconitate
-
-
citrate
-
-
Cu2+
-
0.1 mM, 100% inhibition
D-tryptophan
-
-
Fe2+
-
0.1 mM, 85% inhibition
Hg2+
-
0.1 mM, 94% inhibition
L-Phe
L-phenylalanine
L-Trp
-
at concentration up to 0.1 mM
L-tryptophan
L-Tyr
-
at concentration up to 0.1 mM
L-tyrosine
-
1 mM, 66% inhibition
m-Chlorophenylalanine
-
-
m-Fluorophenylalanine
m-hydroxyphenylalanine
-
-
N-carbobenzoxyphenylalanine
-
-
N-ethylmaleimide
-
-
Ni2+
-
0.1 mM, 83% inhibition
o-chlorophenylalanine
-
-
o-Fluorophenylalanine
-
-
o-hydroxyphenylalanine
-
-
p-Chlorophenylalanine
-
-
p-Fluorophenylalanine
Phe
0.005 mM, 66% inhibition, competitive with prephenate
tetrathionate
-
-
trans-aconitate
-
-
Zn2+
-
0.1 mM, 58% inhibition
additional information
-