4.2.1.49: urocanate hydratase

This is an abbreviated version!
For detailed information about urocanate hydratase, go to the full flat file.

Reaction

Synonyms

4'-Imidazolone-5'-propionate hydro-lyase, 4,5-dihydro-4-oxo-5-imidazole-propanoate hydro-lyase, 4-Imidazolone-5'-propionate hydrolyase, HutU, Hydratase, urocanate, Imidazolonepropionate hydrolase, UROC1, Urocanase

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.1 Hydro-lyases

                4.2.1.49 urocanate hydratase

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Results	in table
22924	AA Sequence
1	Application
1	CAS Registry Number
6	Cloned(Commentary)
22	Cofactor
4	Crystallization (Commentary)
29	Disease/ Diagnostics
1	Expression
7	General Information
1	General Stability
111	Inhibitors
1	Ki Value [mM]
15	KM Value [mM]
15	Molecular Weight [Da]
76	Natural Substrates/ Products (Substrates)
199	Organism
8	Pathway
18	PDB ID
7	pH Optimum
1	pH Range
1	pI Value
3	Protein Variants
13	Purification (Commentary)
28	Reaction
1	Reaction Type
82	Reference
17	Source Tissue
18	Specific Activity [micromol/min/mg]
6	Storage Stability
166	Substrates and Products (Substrate)
12	Subunits
14	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
4	Temperature Range [°C]
3	Temperature Stability [°C]

Disease

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Disease on EC 4.2.1.49 - urocanate hydratase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Ataxia

Mutations in the urocanase gene UROC1 are associated with urocanic aciduria.

19304569

Carcinoma, Hepatocellular

A lipotrope-dependent increase of histidase and urocanase in the livers of choline-deficient rats and in the Reuber H-35 transplanted hepatoma.

4148642

Hepatitis

Histidase and urocanase activities of liver and plasma. Correlations between tissue enzyme levels and plasmatic increases during human and mouse viral hepatitis.

5962915

Hepatitis A

DETECTION OF HISTIDASE AND UROCANASE IN BLOOD OF PATIENTS WITH INFECTIOUS HEPATITIS.

14185909

Hyperthyroidism

Quantification of the carbon flow through the folate-dependent one-carbon pool using radiolabeled histidine: effect of altered thyroid and folate status.

8638944

Intellectual Disability

Mutations in the urocanase gene UROC1 are associated with urocanic aciduria.

19304569

Intellectual Disability

Untargeted metabolomics identifies unique though benign biochemical changes in patients with pathogenic variants in UROC1.

30619714

Liver Diseases

Investigations on correlations between serum enzymes and histological findings in liver disease. With special reference to transaminases and urocanase.

4145127

Liver Diseases

Study of serum urocanase in liver diseases.

5560981

Malnutrition

Histidine metabolism in experimental protein malnutrition in rats.

16749119

Neoplasms

ENZYMES OF HISTIDINE METABOLISM IN NORMAL AND TUMOR TISSUES; HISTIDASE AND UROCANASE ACTIVITY.

14249832

urocanate hydratase deficiency

A liver urocanase deficiency.

6107814

urocanate hydratase deficiency

Untargeted metabolomics identifies unique though benign biochemical changes in patients with pathogenic variants in UROC1.

30619714

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