4.2.1.49: urocanate hydratase

This is an abbreviated version!
For detailed information about urocanate hydratase, go to the full flat file.

Word Map on EC 4.2.1.49

Reaction

3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate
=
Urocanate
+
H2O

Synonyms

Urocanase, Hydratase, urocanate, 4'-Imidazolone-5'-propionate hydro-lyase, 4-Imidazolone-5'-propionate hydrolyase, Imidazolonepropionate hydrolase, 4,5-dihydro-4-oxo-5-imidazole-propanoate hydro-lyase, UROC1, HutU

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.49 urocanate hydratase

Reference

Reference on EC 4.2.1.49 - urocanate hydratase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kaminskas, E.; Kimhi, Y.; Magasanik, B.
Urocanase and N-formimino-L-glutamate formiminohydrolase of Bacillus subtilis, two enzymes of the histidine degradation pathway
J. Biol. Chem.
245
3536-3544
1970
Klebsiella aerogenes, Bacillus subtilis, Salmonella enterica subsp. enterica serovar Typhimurium, Bacillus subtilis SH-11
Manually annotated by BRENDA team
George, D.J.; Phillips, A.T.
Identification of alpha-ketobutyrate as the prosthetic group of urocanase from Pseudomonas putida
J. Biol. Chem.
245
528-537
1970
Gallus gallus, Felis catus, Pseudomonas putida
Manually annotated by BRENDA team
Kaeppeli, F.; Retey, J.
Studies on the mechanism and stereospecificity of the urocanase reaction
Eur. J. Biochem.
23
198-202
1971
Bos taurus, Pseudomonas putida
Manually annotated by BRENDA team
Magasanik, B.; Kaminskas, E.; Kimhi, Y.
Urocanase (Bacillus subtilis)
Methods Enzymol.
17B
51-55
1971
Klebsiella aerogenes, Bacillus subtilis, Bacillus subtilis SH-11
-
Manually annotated by BRENDA team
Phillips, A.T.; George, D.J.
Urocanase (Pseudomonas putida)
Methods Enzymol.
17B
73-79
1971
Bos taurus, Felis catus, Pseudomonas putida
-
Manually annotated by BRENDA team
Hassall, H.; Greenberg, D.M.
Urocanase (beef liver)
Methods Enzymol.
17B
84-88
1971
Bos taurus
-
Manually annotated by BRENDA team
Lynch, M.C.; Phillips, A.T.
Urocanase of Pseudomonas putida
J. Biol. Chem.
247
7799-7805
1972
Pseudomonas putida
Manually annotated by BRENDA team
Hug, D.H.; Roth, D.
Inhibition of urocanase by cupric ion
Biochim. Biophys. Acta
293
497-505
1973
Pseudomonas putida, Pseudomonas putida A3.12
Manually annotated by BRENDA team
Hug, D.H.; Hunter, J.K.
Effect of temperature on urocanase from a psychrophile, Pseudomonas putida
Biochemistry
13
1427-1430
1974
Pseudomonas putida, Rattus norvegicus, Pseudomonas putida A3.12
Manually annotated by BRENDA team
Cohn, M.S.; Lynch, M.C.; Phillips, A.T.
Catalytic and thermodynamic properties of the urocanate hydratase reaction
Biochim. Biophys. Acta
377
444-453
1975
Pseudomonas putida
Manually annotated by BRENDA team
Lane R.S.; Scheuer, S.A.; Thill, G.; Dyll, R.J.
Irreversible inactivation of urocanase by 4-bromocrotonate
Biochem. Biophys. Res. Commun.
71
400-407
1976
Pseudomonas putida
Manually annotated by BRENDA team
Egan, R.M.; Phillips, A.T.
Presence of tightly bound NAD+ in urocanase of Pseudomonas putida
J. Biol. Chem.
252
5701-5707
1977
Pseudomonas putida, Pseudomonas putida A3.12
Manually annotated by BRENDA team
Klee, C.B.; La John, L.E.; Kirk, K.L.; Cohen, L.A.
2-Fluorourocanic acid, a potent reversible inhibitor of urocanase
Biochem. Biophys. Res. Commun.
75
674-681
1977
Pseudomonas fluorescens
Manually annotated by BRENDA team
Hug, D.H.; O'Donnell, P.S.; Hunter, J.K.
Photoactivation of urocanase in Pseudomonas putida
J. Biol. Chem.
253
7622-7629
1978
Pseudomonas putida, Pseudomonas putida A3.12
Manually annotated by BRENDA team
Hug, D.H.; O'Donnell, P.S.; Hunter, J.K.
Thioglycolate, competitive inhibitor of urocanase
Biochem. Biophys. Res. Commun.
81
1435-1442
1978
Pseudomonas putida, Pseudomonas putida A3.12
Manually annotated by BRENDA team
Hacking, A.J.; Bell, M.V.; Hassall, H.
The purification and properties of urocanase from Pseudomonas testosteroni
Biochem. J.
171
41-50
1978
Klebsiella aerogenes, Bacillus subtilis, Bos taurus, Gallus gallus, Comamonas testosteroni, Felis catus, Comamonas testosteroni N.C.I.B. 10808
Manually annotated by BRENDA team
Keul, V.; Kaeppeli, F.; Ghosh, C.; Krebs, T.; Robinson, J.A.; Retey, J.
Identification of the prosthetic group of urocanase
J. Biol. Chem.
254
843-851
1979
Bos taurus, Pseudomonas putida
Manually annotated by BRENDA team
O'Donnell, P.S.; Hug, D.H.; Hunter, J.K.
Sulfhydryl groups in urocanase: Relationship to nicotinamide adenine dinucleotide binding
Arch. Biochem. Biophys.
202
242-249
1980
Pseudomonas putida, Pseudomonas putida A3.12
Manually annotated by BRENDA team
Gerlinger, E.; Hull, W.E.; Retey, J.
Mechanistic study of urocanase reaction using deuterated substrates and 1H-NMR spectroscopy
Eur. J. Biochem.
117
629-634
1981
Pseudomonas putida
Manually annotated by BRENDA team
Hug, D.H.; Hunter, J.K.
Roles of cysteine sulfinate and transaminase on in vivo dark reversion of urocanase in Pseudomonas putida
J. Bacteriol.
151
813-818
1982
Pseudomonas putida, Pseudomonas putida A3.12
Manually annotated by BRENDA team
Matherly, L.H.; Phillips, A.T.
Identification of enol tautomer of imidazolone propionate as the urocanase reaction product
Arch. Biochem. Biophys.
220
314-317
1983
Pseudomonas putida
Manually annotated by BRENDA team
Gerlinger, E.; Hull, W.E.; Retey, J.
Mechanistic studies of the urocanase reaction using 1H- and 31P-NMR spectroscopy and the substrate analogue 2-methylurocanate
Tetrahedron
39
3523-3528
1983
Pseudomonas putida
-
Manually annotated by BRENDA team
Hug, D.H.; O'Donnell, P.S.
Evidence against a temperature-dependent conformational change in urocanase from Pseudomonas putida
Biochim. Biophys. Acta
830
101-104
1985
Pseudomonas putida, Pseudomonas putida A3.12
Manually annotated by BRENDA team
Consevage, M.W.; Porter, R.D.; Phillips, A.T.
Cloning and expression in Escherichia coli of histidine utilization genes from Pseudomonas putida
J. Bacteriol.
162
138-146
1985
Pseudomonas putida
Manually annotated by BRENDA team
Venema, R.C.; Hug, D.H.
Activation of urocanase from Pseudomonas putida by electronically excited triplet species
J. Biol. Chem.
260
12190-12193
1985
Pseudomonas putida, Pseudomonas putida A3.12
Manually annotated by BRENDA team
Gerlinger, E.; Retey, J.
Proposal for the mechanism of action of urocanase. Interference from the inhibition by 2-methylurocanate
Z. Naturforsch. C
42
349-352
1987
Pseudomonas putida
Manually annotated by BRENDA team
Hug, D.H.; Hunter, J.K.; Bedell, B.A.
Photo- and thermal-activation of bovine liver urocanase
Photochem. Photobiol.
48
763-766
1988
Bos taurus
Manually annotated by BRENDA team
O'Donnell, P.S.; Hug, D.H.
Thermal activation of photoactivatable urocanase from Pseudomonas putida
J. Photochem. Photobiol. B, Biol.
3
429-435
1989
Pseudomonas putida, Pseudomonas putida A3.12
Manually annotated by BRENDA team
Hunter, J.K.; Hug, D.H.
Specific inhibition of bacterial and bovine urocanase by glycylglycine
Pept. Res.
2
240-245
1989
Bos taurus, Pseudomonas putida, Pseudomonas putida A3.12
Manually annotated by BRENDA team
Klepp, J.; Fallert-Mller, A.; Grimm, K.; Hull, W.E.; Retey, J.
Mechanism of action of urocanase
Eur. J. Biochem.
192
669-676
1990
Pseudomonas putida
Manually annotated by BRENDA team
Klepp, J.; Retey, J.
The stoichiometry of the tightly bound NAD+ in urocanase
Eur. J. Biochem.
185
615-619
1989
Pseudomonas putida
Manually annotated by BRENDA team
Koberstaedt, A.; Lenz, M.; Retey, J.
Isolation, sequencing and expression in E. coli of the urocanase gene from white clover (Trifolium repens)
FEBS Lett.
311
206-208
1992
Trifolium repens
Manually annotated by BRENDA team
Lenz, M.; Retey, J.
Cloning, expression and mutational analysis of the urocanase gene (hutU) from Pseudomonas putida
Eur. J. Biochem.
217
429-434
1993
Pseudomonas putida
Manually annotated by BRENDA team
Retey, J.
The urocanase story: A novel role of NAD+ as electrophile
Arch. Biochem. Biophys.
314
1-16
1994
Klebsiella aerogenes, Bacillus subtilis, Bos taurus, Cavia porcellus, Gallus gallus, Clostridium tetanomorphum, Felis catus, Pseudomonas putida, Rattus norvegicus, Trifolium repens
Manually annotated by BRENDA team
Schubert, C.; Roettele, H.; Spraul, M.; Retey, J.
On the mechanism of action of urocanase: observation of the enzyme-bound NAD+ -inhibitor adduct by 13C NMR spectroscopy
Angew. Chem. Int. Ed. Engl.
34
652-4
1995
Pseudomonas putida
-
Manually annotated by BRENDA team
Kessler, D.; Retey, J.; Schulz, G.E.
Structure and action of urocanase
J. Mol. Biol.
342
183-194
2004
Pseudomonas putida (P25080), Pseudomonas putida
Manually annotated by BRENDA team
Espinos, C.; Pineda, M.; Martinez-Rubio, D.; Lupo, V.; Ormazabal, A.; Vilaseca, M.A.; Spaapen, L.J.; Palau, F.; Artuch, R.
Mutations in the urocanase gene UROC1 are associated with urocanic aciduria
J. Med. Genet.
46
407-411
2009
Homo sapiens
Manually annotated by BRENDA team
Cabral, M.P.; Soares, N.C.; Aranda, J.; Parreira, J.R.; Rumbo, C.; Poza, M.; Valle, J.; Calamia, V.; Lasa, I.; Bou, G.
Proteomic and functional analyses reveal a unique lifestyle for Acinetobacter baumannii biofilms and a key role for histidine metabolism
J. Proteome Res.
10
3399-3417
2011
Acinetobacter baumannii, Acinetobacter baumannii ATCC 17978
Manually annotated by BRENDA team
Bender, R.A.
Regulation of the histidine utilization (Hut) system in bacteria
Microbiol. Mol. Biol. Rev.
76
565-584
2012
Pseudomonas syringae
Manually annotated by BRENDA team
Ramesh Babu, P.; Anirudh, C.; Rajasulochana, P.; Jaya Laxmi, T.
Structural elucidation of urocanate hydratase protein isolated from Salmonella typhi
Middle East J. Sci. Res.
20
1417-1420
2014
Salmonella enterica subsp. enterica serovar Typhi (Q8Z897)
-
Manually annotated by BRENDA team
Boreiko, S.; Silva, M.; Iulek, J.
Crystallization and X ray diffraction data analyses of the enzyme urocanate hydratase from Trypanosoma cruzi
Rev. Virt. Quim.
8
678-686
2016
Trypanosoma cruzi (Q4D9S6), Trypanosoma cruzi CL Brener (Q4D9S6)
-
Manually annotated by BRENDA team