4.2.1.49: urocanate hydratase

This is an abbreviated version!
For detailed information about urocanate hydratase, go to the full flat file.

Word Map on EC 4.2.1.49

Reaction

3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate
=
Urocanate
+
H2O

Synonyms

Urocanase, Hydratase, urocanate, 4'-Imidazolone-5'-propionate hydro-lyase, 4-Imidazolone-5'-propionate hydrolyase, Imidazolonepropionate hydrolase, 4,5-dihydro-4-oxo-5-imidazole-propanoate hydro-lyase, UROC1, HutU

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.49 urocanate hydratase

Application

Application on EC 4.2.1.49 - urocanate hydratase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
-
L70P and R450C mutations in the coding region of the UROC1 gene in a girl with urocanic aciduria presenting with mental retardation and intermittent ataxia. Both mutations cannot produce a fully functional enzyme, L70P substitution implies the disruption of an alpha-helix in the N-terminus, which alters its properties and therefore, its function. The R450C change renders impossible any interaction between urocanase and its substrate and loses its enzyme activity