4.2.1.19: imidazoleglycerol-phosphate dehydratase

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For detailed information about imidazoleglycerol-phosphate dehydratase, go to the full flat file.

Word Map on EC 4.2.1.19

4.2.1.19

herbicide

auxotrophs

3-amino-1,2,4-triazole

phosphonate

histidinol

Reaction

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate

Synonyms

dehydratase, imidazoleglycerol phosphate, His3, HisB, HisN5B, IGP dehydratase, IGPD, imidazoleglycerol phosphate dehydratase, imidazoleglycerolphoshate dehydratase

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.1 Hydro-lyases

4.2.1.19 imidazoleglycerol-phosphate dehydratase

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Results	in table
3	Activating Compound
34630	AA Sequence
1	CAS Registry Number
10	Cloned(Commentary)
7	Crystallization (Commentary)
4	General Stability
20	Inhibitors
4	Ki Value [mM]
9	KM Value [mM]
1	Localization
10	Metals/Ions
16	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
33	Organism
1	Oxidation Stability
6	Pathway
137	PDB ID
5	pH Optimum
2	pH Range
1	pH Stability
1	Protein Variants
11	Purification (Commentary)
4	Reaction
1	Reaction Type
33	Reference
6	Source Tissue
3	Specific Activity [micromol/min/mg]
33	Substrates and Products (Substrate)
10	Subunits
16	Synonyms
1	Systematic Name
2	Temperature Stability [°C]
1	Turnover Number [1/s]

Crystallization

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Crystallization on EC 4.2.1.19 - imidazoleglycerol-phosphate dehydratase

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crystallized in presence of Mn, unit-cell parameters: a = b = 157.9 A, c = 480 A, alpha = beta = 90°, gamma = 120°, with either 16 or 24 subunits in the asymmetric unit, space group R3, 3.0 A resolution

Arabidopsis thaliana

663551

crystals belong to space group R3 with cell parameters a = 157.9 A, b = 157.9 A, c = 480 A, alpha = beta = 90°, gamma = 120°. Structure of manganese assembled, active form of the enzyme at 3.0 A resolution

Arabidopsis thaliana

666944

structure of isoform IGPD2 in complex with phosphate, to 1.75 A resolution. The holoenzyme has an open conformation where the C-terminal region (R193-R206, termed the C loop), which contains a number of conserved residues, is disordered. structure of mutant E21Q, to 1.12 A resolution

Arabidopsis thaliana

O23346

749384

trimeric form without Mn2+, hanging drop vapor diffusion method

Cryptococcus neoformans

P0CO22

652527

3 entries