4.2.1.19: imidazoleglycerol-phosphate dehydratase

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For detailed information about imidazoleglycerol-phosphate dehydratase, go to the full flat file.

Word Map on EC 4.2.1.19

4.2.1.19

herbicide

auxotrophs

3-amino-1,2,4-triazole

phosphonate

histidinol

Reaction

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate

Synonyms

dehydratase, imidazoleglycerol phosphate, His3, HisB, HisN5B, IGP dehydratase, IGPD, imidazoleglycerol phosphate dehydratase, imidazoleglycerolphoshate dehydratase

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.1 Hydro-lyases

4.2.1.19 imidazoleglycerol-phosphate dehydratase

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Results	in table
3	Activating Compound
34630	AA Sequence
1	CAS Registry Number
10	Cloned(Commentary)
7	Crystallization (Commentary)
4	General Stability
20	Inhibitors
4	Ki Value [mM]
9	KM Value [mM]
1	Localization
10	Metals/Ions
16	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
33	Organism
1	Oxidation Stability
6	Pathway
137	PDB ID
5	pH Optimum
2	pH Range
1	pH Stability
1	Protein Variants
11	Purification (Commentary)
4	Reaction
1	Reaction Type
33	Reference
6	Source Tissue
3	Specific Activity [micromol/min/mg]
33	Substrates and Products (Substrate)
10	Subunits
16	Synonyms
1	Systematic Name
2	Temperature Stability [°C]
1	Turnover Number [1/s]

Metals Ions

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Metals Ions on EC 4.2.1.19 - imidazoleglycerol-phosphate dehydratase

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Mg2+

Cryptococcus neoformans

P0CO22

metalloprotein, transition metals induce aggregation and are required for catalysis, 1 equivalent of Mn2+ per subunit induces the formation of 24-mers from the trimeric enzyme

652527

Arabidopsis thaliana

the manganese cluster is critical in converting the inactive trimeric state of the enzyme into its biologically active 24-mer and also forms the active site. The substrate is bound to the manganese cluster as an imidazole moiety that subsequently collapse to yield a diazafulvene intermediate

666944

Mn2+

6 entries

additional information

2 entries