4.2.1.19: imidazoleglycerol-phosphate dehydratase

This is an abbreviated version!
For detailed information about imidazoleglycerol-phosphate dehydratase, go to the full flat file.

Reaction

Synonyms

dehydratase, imidazoleglycerol phosphate, His3, HisB, HisN5B, IGP dehydratase, IGPD, imidazoleglycerol phosphate dehydratase, imidazoleglycerolphoshate dehydratase

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.1 Hydro-lyases

                4.2.1.19 imidazoleglycerol-phosphate dehydratase

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Results	in table
3	Activating Compound
34630	AA Sequence
1	CAS Registry Number
10	Cloned(Commentary)
7	Crystallization (Commentary)
4	General Stability
20	Inhibitors
4	Ki Value [mM]
9	KM Value [mM]
1	Localization
10	Metals/Ions
16	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
33	Organism
1	Oxidation Stability
6	Pathway
137	PDB ID
5	pH Optimum
2	pH Range
1	pH Stability
1	Protein Variants
11	Purification (Commentary)
4	Reaction
1	Reaction Type
33	Reference
6	Source Tissue
3	Specific Activity [micromol/min/mg]
33	Substrates and Products (Substrate)
10	Subunits
16	Synonyms
1	Systematic Name
2	Temperature Stability [°C]
1	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 4.2.1.19 - imidazoleglycerol-phosphate dehydratase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

3-Amino-1,2,4-triazole

10 entries

EDTA

Neurospora crassa

-

-

5538

phosphate

3 entries

Zn2+

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

5535

[3-Hydroxy-2-(1H-[1,2,4]triazol-3-yl)-butyl]-phosphonic acid

Triticum aestivum

-

IRL 1803

5547

[3-Hydroxy-2-(1H-[1,2,4]triazol-3-yl)-cyclohexyl]-phosphonic acid

Triticum aestivum

-

IRL 1856

5547

[3-Hydroxy-2-(1H-[1,2,4]triazol-3-yl)-propyl]-phosphonic acid

Triticum aestivum

-

IRL 1695

5547

additional information

Saccharomyces cerevisiae

-

not inhibited by histidinol phosphate, histidinol, histidine

5534

-

3-Amino-1,2,4-triazole

Arabidopsis thaliana

-

-

5545

3-Amino-1,2,4-triazole

Mycobacterium tuberculosis

-

competitive

728872

3-Amino-1,2,4-triazole

Saccharomyces cerevisiae

-

-

5532

3-Amino-1,2,4-triazole

Saccharomyces cerevisiae

-

Ki: 0.03 mM

5533

3-Amino-1,2,4-triazole

Saccharomyces cerevisiae

-

-

5534

3-Amino-1,2,4-triazole

Saccharomyces cerevisiae

-

Ki: 0.12 mM

5546

3-Amino-1,2,4-triazole

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

5535, 5536

3-Amino-1,2,4-triazole

Staphylococcus aureus

-

-

5536

3-Amino-1,2,4-triazole

Triticum aestivum

-

-

5540

3-Amino-1,2,4-triazole

Triticum aestivum

-

Ki: 0.0026 mM

5545

phosphate

Arabidopsis thaliana

O23346

-

749384

phosphate

Saccharomyces cerevisiae

-

Ki: 0.008 mM

5533

phosphate

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

5535