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3.5.1.46: 6-aminohexanoate-oligomer exohydrolase

This is an abbreviated version!
For detailed information about 6-aminohexanoate-oligomer exohydrolase, go to the full flat file.

Word Map on EC 3.5.1.46

Reaction

N-(6-aminohexanoyl)-6-aminohexanoate
+
H2O
= 2 6-aminohexanoate

Synonyms

6-aminohexanoic acid oligomer hydrolase, EII, EII', Nylon oligomers degrading enzyme EII, Nylon oligomers degrading enzyme EII', nylon oligomer hydrolase, 6-aminohexanoate oligomer hydrolase, NylCA, NylCK, NylCP2, Hyb-24DN, nylon-oligomer degrading enzyme, NylB, 6-aminohexanoate-dimer hydrolase, N-(6-aminohexanoyl)-6-aminohexanoate amidohydrolase, 6-aminohexanoate dimer hydrolase, Ahx dimer hydrolase, Hyb-24

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.46 6-aminohexanoate-oligomer exohydrolase

General Information

General Information on EC 3.5.1.46 - 6-aminohexanoate-oligomer exohydrolase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
the yield of this reverse reaction in 90% t-butyl alcohol vaies drastically when enzyme mutants with substitutions of several amino acids located at the entrance of the catalytic cleft are used
metabolism
enzymatic degradation of 6-aminohexanoate and its oligomers in Arthrobacter sp. KI7 by the Nyl enzymes. A 6-aminohexanoate oligomer is converted to adipate, pathway overview. 6-Aminohexanoate oligomers are almost completely converted to the monomers (Ahx) by the three nylon oligomer-degrading enzymes, NylA, NylB, and NylC. 6-Aminohexanoate aminotransferase (NylD1) catalyzes the reaction of 6-aminohexanoate to adipate semialdehyde using alpha-oxoglutarate, pyruvate, and glyoxylate as amino acceptors, generating glutamate, alanine, and glycine, respectively. The reaction requires pyridoxal phosphate as a cofactor. For further metabolism, adipate semialdehyde dehydrogenase (NylE1) catalyzes the oxidative reaction of adipate semialdehyde to adipate using NADP+ as a cofactor
evolution
additional information