Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-aminohexanoate dimer + H2O | Paenarthrobacter ureafaciens | the enzyme hydrolyzes the Ahx oligomers by an exo-type mechanism | 2 6-aminohexanoate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Paenarthrobacter ureafaciens | P07061 | i.e. Flavobacterium sp. K172 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-aminohexanoate dimer + H2O | - |
Paenarthrobacter ureafaciens | 2 6-aminohexanoate | - |
? | |
6-aminohexanoate dimer + H2O | the enzyme hydrolyzes the Ahx oligomers by an exo-type mechanism | Paenarthrobacter ureafaciens | 2 6-aminohexanoate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
6-aminohexanoate dimer hydrolase | - |
Paenarthrobacter ureafaciens |
Ahx dimer hydrolase | - |
Paenarthrobacter ureafaciens |
NylB | - |
Paenarthrobacter ureafaciens |
General Information | Comment | Organism |
---|---|---|
evolution | Ahx dimer hydrolase (NylB), a member of the penicillin-recognizing family of serine-reactive hydrolases | Paenarthrobacter ureafaciens |
metabolism | enzymatic degradation of 6-aminohexanoate and its oligomers in Arthrobacter sp. KI7 by the Nyl enzymes. A 6-aminohexanoate oligomer is converted to adipate, pathway overview. 6-Aminohexanoate oligomers are almost completely converted to the monomers (Ahx) by the three nylon oligomer-degrading enzymes, NylA, NylB, and NylC. 6-Aminohexanoate aminotransferase (NylD1) catalyzes the reaction of 6-aminohexanoate to adipate semialdehyde using alpha-oxoglutarate, pyruvate, and glyoxylate as amino acceptors, generating glutamate, alanine, and glycine, respectively. The reaction requires pyridoxal phosphate as a cofactor. For further metabolism, adipate semialdehyde dehydrogenase (NylE1) catalyzes the oxidative reaction of adipate semialdehyde to adipate using NADP+ as a cofactor | Paenarthrobacter ureafaciens |
additional information | enzyme Ahx dimer hydrolase hydrolyzes the Ahx oligomers by an exo-type mechanism | Paenarthrobacter ureafaciens |