Literature summary for 3.5.1.46 extracted from

akehara, I.; Fujii, T.; Tanimoto, Y.; Kato, D.I.; Takeo, M.; Negoro, S.
Metabolic pathway of 6-aminohexanoate in the nylon oligomer-degrading bacterium Arthrobacter sp. KI72 identification of the enzymes responsible for the conversion of 6-aminohexanoate to adipate (2018), Appl. Microbiol. Biotechnol., 102, 801-814 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
6-aminohexanoate dimer + H2O	Paenarthrobacter ureafaciens	the enzyme hydrolyzes the Ahx oligomers by an exo-type mechanism	2 6-aminohexanoate	-	?

Organism

Organism	UniProt	Comment	Textmining
Paenarthrobacter ureafaciens	P07061	i.e. Flavobacterium sp. K172	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6-aminohexanoate dimer + H2O	-	Paenarthrobacter ureafaciens	2 6-aminohexanoate	-	?
6-aminohexanoate dimer + H2O	the enzyme hydrolyzes the Ahx oligomers by an exo-type mechanism	Paenarthrobacter ureafaciens	2 6-aminohexanoate	-	?

Synonyms

Synonyms	Comment	Organism
6-aminohexanoate dimer hydrolase	-	Paenarthrobacter ureafaciens
Ahx dimer hydrolase	-	Paenarthrobacter ureafaciens
NylB	-	Paenarthrobacter ureafaciens

General Information

General Information	Comment	Organism
evolution	Ahx dimer hydrolase (NylB), a member of the penicillin-recognizing family of serine-reactive hydrolases	Paenarthrobacter ureafaciens
metabolism	enzymatic degradation of 6-aminohexanoate and its oligomers in Arthrobacter sp. KI7 by the Nyl enzymes. A 6-aminohexanoate oligomer is converted to adipate, pathway overview. 6-Aminohexanoate oligomers are almost completely converted to the monomers (Ahx) by the three nylon oligomer-degrading enzymes, NylA, NylB, and NylC. 6-Aminohexanoate aminotransferase (NylD1) catalyzes the reaction of 6-aminohexanoate to adipate semialdehyde using alpha-oxoglutarate, pyruvate, and glyoxylate as amino acceptors, generating glutamate, alanine, and glycine, respectively. The reaction requires pyridoxal phosphate as a cofactor. For further metabolism, adipate semialdehyde dehydrogenase (NylE1) catalyzes the oxidative reaction of adipate semialdehyde to adipate using NADP+ as a cofactor	Paenarthrobacter ureafaciens
additional information	enzyme Ahx dimer hydrolase hydrolyzes the Ahx oligomers by an exo-type mechanism	Paenarthrobacter ureafaciens

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Release 2023.1 (January 2023)