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3.5.1.26: N4-(beta-N-acetylglucosaminyl)-L-asparaginase

This is an abbreviated version!
For detailed information about N4-(beta-N-acetylglucosaminyl)-L-asparaginase, go to the full flat file.

Word Map on EC 3.5.1.26

Reaction

N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine
+
H2O
=
N-acetyl-beta-D-glucosaminylamine
 +
L-aspartate

Synonyms

1-aspartamido-beta-N-acetylglucosamine amidohydrolase, 4-L-aspartylglucosylamine amido hydrolase, AGA, amidase-1, amidase-2, amidase-3, aspartylglucosaminidase, aspartylglucosylaminase, aspartylglucosylamine deaspartylase, aspartylglycosylamine amidohydrolase, AtAGA, beta-aspartylglucosylamine amidohydrolase, EC 3.5.1.37, GA, glucosylamidase, glycoasparaginase, glycosylasparaginase, LhAGA, More, N-aspartyl-beta-glucosaminidase, N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.26 N4-(beta-N-acetylglucosaminyl)-L-asparaginase

Inhibitors

Inhibitors on EC 3.5.1.26 - N4-(beta-N-acetylglucosaminyl)-L-asparaginase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
-
90% inhibition at 0.1%, v/v
3-hydroxybutanone
-
competitive inhibition, Ki: 4.1 mM
3-phosphono-DL-2-aminopropionic acid
-
phosphono transition state mimic, competitive inhibitor
5-Diazo-4-oxo-L-norvaline
acetate
-
slight inhibition at 3.2 mM
aspartic acid
-
40% inhibition at 1 mM
Aspartylaniline
-
competitive inhibition
Aspartylcyclohexylamine
-
competitive inhibition
bafilomycin A1
-
-
Chloroquine
-
-
EDTA
-
50% inhibition at 1 mM
glycine
L-2-bromosuccinic acid
-
competitive inhibitor
L-2-chlorosuccinic acid
-
competitive inhibitor
L-2-methylsuccinic acid
-
competitive inhibitor
L-asparagine
L-aspartic acid
-
competitive inhibitor
L-cysteic acid
-
sulfo transition state mimic, competitive inhibitor
N-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)bromoacetamide
-
substrate analogue, noncompetitive inhibitor
N-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)chloroacetamide
-
substrate analogue, noncompetitive inhibitor
N-acetylcysteine
N1-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)glycinamide
-
substrate analogue, noncompetitive inhibitor
p-chloromercuribenzoate
-
50% inhibition at 1 mM
succinic acid
-
competitive inhibitor
additional information
-