3.5.1.25: N-acetylglucosamine-6-phosphate deacetylase
This is an abbreviated version!
For detailed information about N-acetylglucosamine-6-phosphate deacetylase, go to the full flat file.
Word Map on EC 3.5.1.25
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3.5.1.25
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deaminase
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chitin
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fructose-6-phosphate
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glcn-6-phosphate
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non-o1
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drug development
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diagnostics
- 3.5.1.25
- deaminase
- chitin
- fructose-6-phosphate
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glcn-6-phosphate
- non-o1
- drug development
- diagnostics
Reaction
Synonyms
2-acetamido-2-deoxy-D-glucose-6-phosphate amidohydrolase, acetylaminodeoxyglucosephosphate acetylhydrolase, acetylglucosamine phosphate deacetylase, CaNAG2/Dac1, deacetylase, acetylglucosaminephosphate, EC 3.5.1.80, GlcNAc 6-P deacetylase, GlcNAc-6-phosphate deacetylase, GlnNAc6P deacetylase, Lmo0956, Lmo0956 protein, Lmo2108, Lmo2108 protein, MMNagA, MSNagA, N-acetyl-D-glucosamine-6-phosphate deacetylase, N-acetylglucosamine 6-phosphate deacetylase, N-acetylglucosamine-6-P deacetylase, N-acetylglucosamine-6-phosphate de-N-acetylase, N-acetylglucosamine-6-phosphate deacetylase, NAG2, NagA, NAGPase
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Engineering
Engineering on EC 3.5.1.25 - N-acetylglucosamine-6-phosphate deacetylase
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additional information
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a nagA mutation causes the accumulation of the allosteric activator GlcNAc6P, permitting allosteric activation of nagB, the GlcNAc6P deaminase, and derepresses the nag operon, with a stronger effect than a mutation of nagC, structure of the nag operon, overview
additional information
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mutations in nagA result in accumulation of millimolar of N-acetylglucosamine, presumably by preventing peptidoglycan recycling. Mutations in the genes encoding the key enzymes upstream of nagA in the recycling pathway (amG, nagZ, nagK, murQ, and anmK), which are expected to interrupt the recycling process, reduce but do not eliminate accumulation of N-acetyl-6-phosphate
additional information
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mutations in nagA result in accumulation of millimolar of N-acetylglucosamine, presumably by preventing peptidoglycan recycling. Mutations in the genes encoding the key enzymes upstream of nagA in the recycling pathway (amG, nagZ, nagK, murQ, and anmK), which are expected to interrupt the recycling process, reduce but do not eliminate accumulation of N-acetyl-6-phosphate
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additional information
knockout of gene lmo0956, phenotype, overview
additional information
knockout of gene lmo0956, phenotype, overview
additional information
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knockout of gene lmo0956, phenotype, overview
additional information
knockout of gene lmo1208, phenotype, overview
additional information
knockout of gene lmo1208, phenotype, overview
additional information
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knockout of gene lmo1208, phenotype, overview
additional information
construction of mutant enzymes mutated to either a QXN motif to replicate the single metal-binding motif found in both the Escherichia coli and Vibrio cholerae NagA enzymes, or to AXA, resulting in highly reduced activity for the QXN mutant and complete loss of activity for the AXA mutant
additional information
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construction of mutant enzymes mutated to either a QXN motif to replicate the single metal-binding motif found in both the Escherichia coli and Vibrio cholerae NagA enzymes, or to AXA, resulting in highly reduced activity for the QXN mutant and complete loss of activity for the AXA mutant