Cloned (Comment) | Organism |
---|---|
gene lmo0956, genetic organization, phylogenetic analysis | Listeria monocytogenes |
gene lmo2108, genetic organization, phylogenetic analysis | Listeria monocytogenes |
Protein Variants | Comment | Organism |
---|---|---|
additional information | knockout of gene lmo0956, phenotype, overview | Listeria monocytogenes |
additional information | knockout of gene lmo1208, phenotype, overview | Listeria monocytogenes |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Listeria monocytogenes | 5737 | - |
cytosol | - |
Listeria monocytogenes | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-D-glucosamine 6-phosphate + H2O | Listeria monocytogenes | - |
D-glucosamine 6-phosphate + acetate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Listeria monocytogenes | Q8Y5F6 | gene lmo2108 | - |
Listeria monocytogenes | Q8Y8E8 | - |
- |
Listeria monocytogenes | Q8Y8E8 | gene lmo0956 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-D-glucosamine 6-phosphate + H2O | - |
Listeria monocytogenes | D-glucosamine 6-phosphate + acetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Lmo0956 | - |
Listeria monocytogenes |
Lmo0956 protein | protein with N-acetylglucosamine-6-phosphate de-N-acetylase domain | Listeria monocytogenes |
Lmo2108 | - |
Listeria monocytogenes |
Lmo2108 protein | protein with N-acetylglucosamine-6-phosphate de-N-acetylase domain | Listeria monocytogenes |
N-acetylglucosamine-6-P deacetylase | - |
Listeria monocytogenes |
N-acetylglucosamine-6-phosphate de-N-acetylase | - |
Listeria monocytogenes |
NagA | - |
Listeria monocytogenes |
General Information | Comment | Organism |
---|---|---|
malfunction | mutants deficient in protein Lmo0956 reveal strikingly altered cell morphology, strongly reduced cell wall murein content and decreased sensitivity to cell wall hydrolase, mutanolysin and peptide antibiotic, colistin | Listeria monocytogenes |
metabolism | gene products of operon 150, consisting of three genes: lmo0956, lmo0957, and lmo0958, are necessary for the cytosolic steps of the amino-sugar-recycling pathway. The reverse reaction to Glc-N-6-P is catalyzed by GlmS | Listeria monocytogenes |
additional information | enzyme structure modeling, overview | Listeria monocytogenes |
physiological function | Lmo0956 protein is required for cell wall peptidoglycan and teichoic acid biosynthesis and is essential for bacterial cell growth, cell division, and sensitivity to cell wall hydrolases and peptide antibiotics. Lmo0956 and Lmo2108 are involved in the deacetylation of muropeptides that have been taken up into the bacterial cell | Listeria monocytogenes |
physiological function | cytoplasmic de-N-acetylase Lmo0956 is required for cell wall peptidoglycan and teichoic acid biosynthesis and is also essential for bacterial cell growth, cell division, and sensitivity to cell wall hydrolases and peptide antibiotics | Listeria monocytogenes |