3.4.24.22: stromelysin 2

This is an abbreviated version!
For detailed information about stromelysin 2, go to the full flat file.

Word Map on EC 3.4.24.22

3.4.24.22

metalloproteinases

mmp-9

collagen

metastasis

timps

endothelial

stromelysin-1

gelatinase

cartilage

basement

keratinocytes

zymography

matrilysin

diagnostics

collagenase-1

collagenolytic

medicine

sdc1

metalloelastase

Reaction

Similar to stromelysin 1, but action on collagen types III, IV and V is weak =

Synonyms

Matrix metalloproteinase 10, Matrix metalloproteinase-10, MMP-10, MMP10, More, Proteoglycanase 2, ST-2, stromelysin 2, stromelysin-2, Transformation-associated protein 34A, Transin 2, Transins, 2

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.22 stromelysin 2

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Results	in table
1	Activating Compound
8	AA Sequence
7	Application
1	CAS Registry Number
11	Cloned(Commentary)
3	Crystallization (Commentary)
1174	Disease/ Diagnostics
14	Expression
50	General Information
22	Inhibitors
3	Ki Value [mM]
2	KM Value [mM]
19	Localization
10	Metals/Ions
3	Molecular Weight [Da]
16	Natural Substrates/ Products (Substrates)
54	Organism
6	PDB ID
4	pH Optimum
1	pH Range
4	Posttranslational Modification
8	Protein Variants
2	Purification (Commentary)
1	Reaction
1	Reaction Type
49	Reference
94	Source Tissue
2	Storage Stability
43	Substrates and Products (Substrate)
1	Subunits
73	Synonyms
2	Temperature Optimum [°C]
1	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 3.4.24.22 - stromelysin 2

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1,10-phenanthroline

DTT

EDTA

EGTA

GM6001

a broad-spectrum MMP inhibitor

707982

N-isobutyl-N-(4-methoxy-phenylsulfonyl)glycyl hydroxamic acid

Homo sapiens

i.e. NNGH, study of binding mode. Interaction of inhibitor with Zn1 atom and S1 subsite

669828

PAI-1

Homo sapiens

functions as an upstream regulator of a MMP-10-initiated collagenolytic phenotype, it blocks conversion of MMP-10 to its active form. Neutralization of endogenous PAI-1 with function blocking antibodies accelerates both collagenolysis and activation of MMP-10

707982

Specific tissue inhibitor of metalloproteinases

2 entries

TIMP-1

3 entries

TIMP-2

2 entries

tissue inhibitor of metalloproteinases 1

Homo sapiens

P01033

TIMP-1, the protein is expressed in HEK 293E cells, enzyme binding structure analysis and mechanism of inhibition, detailed overview and comparison to stromelysin-1, EC 3.4.24.17

734175

tissue inhibitor of metalloproteinases 2

2 entries

additional information

Homo sapiens

P16035

the endogenous tissue inhibitors of metalloproteinases (TIMPs) regulate proteolytic activity by binding tightly to the MMP active site. While each of the four TIMPs can inhibit most MMPs, binding data reveal tremendous heterogeneity in affinities of different TIMP/MMP pairs. Identification of a group of highly conserved contacts at the heart of MMP/TIMP complexes that define the conserved mechanism of inhibition, as well as a second category of diverse adventitious contacts at the periphery of the interfaces

735101