3.4.24.22: stromelysin 2
This is an abbreviated version!
For detailed information about stromelysin 2, go to the full flat file.
Word Map on EC 3.4.24.22
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3.4.24.22
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metalloproteinases
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mmp-9
-
collagen
-
metastasis
-
timps
-
endothelial
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stromelysin-1
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gelatinase
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cartilage
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basement
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keratinocytes
-
zymography
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matrilysin
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diagnostics
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collagenase-1
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collagenolytic
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medicine
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sdc1
-
metalloelastase
- 3.4.24.22
- metalloproteinases
- mmp-9
- collagen
- metastasis
- timps
- endothelial
- stromelysin-1
- gelatinase
- cartilage
-
basement
- keratinocytes
-
zymography
- matrilysin
- diagnostics
- collagenase-1
-
collagenolytic
- medicine
- sdc1
- metalloelastase
Reaction
Similar to stromelysin 1, but action on collagen types III, IV and V is weak =
Synonyms
Matrix metalloproteinase 10, Matrix metalloproteinase-10, MMP-10, MMP10, More, Proteoglycanase 2, ST-2, stromelysin 2, stromelysin-2, Transformation-associated protein 34A, Transin 2, Transins, 2
ECTree
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Reference on EC 3.4.24.22 - stromelysin 2
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Breathnach, R.; Matrisian, L.M.; Gesnel, M.C.; Staub, A.; Leroy, P.
Sequences coding for part of oncogene-induced transin are highly conserved in a related rat gene
Nucleic Acids Res.
15
1139-1151
1987
Rattus norvegicus
Muller, D.; Quantin, B.; Gesnel, M.C.; Millon-Collard, R.; Abecassis, J.; Breathnach, R.
The collagenase gene family in humans consists of at least four members
Biochem. J.
253
187-192
1988
Homo sapiens
Nicholson, R.; Murphy, G.; Breathnach, R.
Human and rat malignant-tumor-associated mRNAs encode stromelysin-like metalloproteinases
Biochemistry
28
5195-5203
1989
Homo sapiens
Meyer, E.; Vollmer, J.Y.; Bovey, R.; Stamenkovic, I.
Matrix metalloproteinases 9 and 10 inhibit protein kinase C-potentiated, p53-mediated apoptosis
Cancer Res.
65
4261-4272
2005
Homo sapiens
Wertz, K.; Seifert, N.; Hunziker, P.B.; Riss, G.; Wyss, A.; Lankin, C.; Goralczyk, R.
beta-Carotene inhibits UVA-induced matrix metalloprotease 1 and 10 expression in keratinocytes by a singlet oxygen-dependent mechanism
Free Radic. Biol. Med.
37
654-670
2004
Homo sapiens
Saunders, W.B.; Bayless, K.J.; Davis, G.E.
MMP-1 activation by serine proteases and MMP-10 induces human capillary tubular network collapse and regression in 3D collagen matrices
J. Cell Sci.
118
2325-2340
2005
Homo sapiens
Van Themsche, C.; Alain, T.; Kossakowska, A.E.; Urbanski, S.; Potworowski, E.F.; St-Pierre, Y.
Stromelysin-2 (matrix metalloproteinase 10) is inducible in lymphoma cells and accelerates the growth of lymphoid tumors in vivo
J. Immunol.
173
3605-3611
2004
Mus musculus
Bertini, I.; Calderone, V.; Fragai, M.; Luchinat, C.; Mangani, S.; Terni, B.
Crystal structure of the catalytic domain of human matrix metalloproteinase 10
J. Mol. Biol.
336
707-716
2004
Homo sapiens
Krampert, M.; Bloch, W.; Sasaki, T.; Bugnon, P.; Ruelicke, T.; Wolf, E.; Aumailley, M.; Parks, W.C.; Werner, S.
Activities of the matrix metalloproteinase stromelysin-2 (MMP-10) in matrix degradation and keratinocyte organization in wounded skin
Mol. Biol. Cell
15
5242-5254
2004
Mus musculus
Aung, P.P.; Oue, N.; Mitani, Y.; Nakayama, H.; Yoshida, K.; Noguchi, T.; Bosserhoff, A.K.; Yasui, W.
Systematic search for gastric cancer-specific genes based on SAGE data: melanoma inhibitory activity and matrix metalloproteinase-10 are novel prognostic factors in patients with gastric cancer
Oncogene
25
2546-2557
2006
Homo sapiens
Salmela, M.T.; Pender, S.L.; Karjalainen-Lindsberg, M.L.; Puolakkainen, P.; Macdonald, T.T.; Saarialho-Kere, U.
Collagenase-1 (MMP-1), matrilysin-1 (MMP-7), and stromelysin-2 (MMP-10) are expressed by migrating enterocytes during intestinal wound healing
Scand. J. Gastroenterol.
39
1095-1104
2004
Homo sapiens
Zhang, X.; Zhu, S.; Luo, G.; Zheng, L.; Wei, J.; Zhu, J.; Mu, Q.; Xu, N.
Expression of MMP-10 in lung cancer
Anticancer Res.
27
2791-2795
2007
Homo sapiens
Barksby, H.E.; Milner, J.M.; Patterson, A.M.; Peake, N.J.; Hui, W.; Robson, T.; Lakey, R.; Middleton, J.; Cawston, T.E.; Richards, C.D.; Rowan, A.D.
Matrix metalloproteinase 10 promotion of collagenolysis via procollagenase activation: implications for cartilage degradation in arthritis
Arthritis Rheum.
54
3244-3253
2006
Homo sapiens
Miyata, Y.; Iwata, T.; Maruta, S.; Kanda, S.; Nishikido, M.; Koga, S.; Kanetake, H.
Expression of matrix metalloproteinase-10 in renal cell carcinoma and its prognostic role
Eur. Urol.
52
791-797
2007
Homo sapiens
Orbe, J.; Montero, I.; Rodriguez, J.A.; Beloqui, O.; Roncal, C.; Paramo, J.A.
Independent association of matrix metalloproteinase-10, cardiovascular risk factors and subclinical atherosclerosis
J. Thromb. Haemost.
5
91-97
2007
Homo sapiens
Richardson, S.M.; Doyle, P.; Minogue, B.M.; Gnanalingham, K.; Hoyland, J.A.
Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral disc
Arthritis Res. Ther.
11
R126
2009
Homo sapiens
Lijnen, H.R.; Van Hoef, B.; Rodriguez, J.A.; Paramo, J.A.
Stromelysin-2 (MMP-10) deficiency does not affect adipose tissue formation in a mouse model of nutritionally induced obesity
Biochem. Biophys. Res. Commun.
389
378-381
2009
Mus musculus
Yen, C.Y.; Chen, C.H.; Chang, C.H.; Tseng, H.F.; Liu, S.Y.; Chuang, L.Y.; Wen, C.H.; Chang, H.W.
Matrix metalloproteinases (MMP) 1 and MMP10 but not MMP12 are potential oral cancer markers
Biomarkers
14
244-249
2009
Homo sapiens
Wilkins-Port, C.E.; Ye, Q.; Mazurkiewicz, J.E.; Higgins, P.J.
TGF-beta1 + EGF-initiated invasive potential in transformed human keratinocytes is coupled to a plasmin/MMP-10/MMP-1-dependent collagen remodeling axis: role for PAI-1
Cancer Res.
69
4081-4091
2009
Homo sapiens
Friese, R.S.; Rao, F.; Khandrika, S.; Thomas, B.; Ziegler, M.G.; Schmid-Schoenbein, G.W.; OConnor, D.T.
Matrix metalloproteinases: discrete elevations in essential hypertension and hypertensive end-stage renal disease
Clin. Exp. Hypertens.
31
521-533
2009
Homo sapiens
Lorente, L.; Martin, M.M.; Labarta, L.; Diaz, C.; Sole-Violan, J.; Blanquer, J.; Orbe, J.; Rodriguez, J.A.; Jimenez, A.; Borreguero-Leon, J.M.; Belmonte, F.; Medina, J.C.; Lliminana, M.C.; Ferrer-Agueero, J.M.; Ferreres, J.; Mora, M.L.; Lubillo, S.; Sanchez, M.; Barrios, Y.; Sierra, A.; Paramo, J.A.
Matrix metalloproteinase-9, -10, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mortality in sepsis
Crit. Care
13
R158
2009
Homo sapiens
Tomomatsu, T.; Takamura, Y.; Kubo, E.; Akagi, Y.
Aldose reductase inhibitor counteracts the attenuated adhesion of human corneal epithelial cells induced by high glucose through modulation of MMP-10 expression
Diabetes Res. Clin. Pract.
86
16-23
2009
Homo sapiens
Boyd, S.; Virolainen, S.; Paerssinen, J.; Skoog, T.; van Hogerlinden, M.; Latonen, L.; Kylloenen, L.; Toftgard, R.; Saarialho-Kere, U.
MMP-10 (Stromelysin-2) and MMP-21 in human and murine squamous cell cancer
Exp. Dermatol.
18
1044-1052
2009
Homo sapiens, Mus musculus, Mus musculus ICR
Komosinska-Vassev, K.; Olczyk, P.; Winsz-Szczotka, K.; Kuznik-Trocha, K.; Klimek, K.; Olczyk, K.
Age- and gender-dependent changes in connective tissue remodeling: physiological differences in circulating MMP-3, MMP-10, TIMP-1 and TIMP-2 Level
Gerontology
57
44-52
2010
Homo sapiens
Heo, S.H.; Choi, Y.J.; Ryoo, H.M.; Cho, J.Y.
Expression profiling of ETS and MMP factors in VEGF-activated endothelial cells: role of MMP-10 in VEGF-induced angiogenesis
J. Cell. Physiol.
224
734-742
2010
Homo sapiens (P09238), Homo sapiens
Kaner, R.J.; Santiago, F.; Crystal, R.G.
Up-regulation of alveolar macrophage matrix metalloproteinases in HIV1(+) smokers with early emphysema
J. Leukoc. Biol.
86
913-922
2009
Homo sapiens
Cuadrado, E.; Rosell, A.; Penalba, A.; Slevin, M.; Alvarez-Sabin, J.; Ortega-Aznar, A.; Montaner, J.
Vascular MMP-9/TIMP-2 and neuronal MMP-10 up-regulation in human brain after stroke: a combined laser microdissection and protein array study
J. Proteome Res.
8
3191-3197
2009
Homo sapiens
Wu, L.; Chien, W.M.; Hartman, M.E.; Moussavi-Harami, F.; Liu, Y.; Chin, M.T.
Regulation of MMP10 expression by the transcription factor CHF1/Hey2 is mediated by multiple E boxes
Biochem. Biophys. Res. Commun.
415
662-668
2011
Mus musculus
Orbe, J.; Barrenetxe, J.; Rodriguez, J.A.; Vivien, D.; Orset, C.; Parks, W.C.; Birkland, T.P.; Serrano, R.; Purroy, A.; Martinez de Lizarrondo, S.; Angles-Cano, E.; Paramo, J.A.
Matrix metalloproteinase-10 effectively reduces infarct size in experimental stroke by enhancing fibrinolysis via a thrombin-activatable fibrinolysis inhibitor-mediated mechanism
Circulation
124
2909-2919
2011
Mus musculus
Deraz, E.M.; Kudo, Y.; Yoshida, M.; Obayashi, M.; Tsunematsu, T.; Tani, H.; Siriwardena, S.B.; Kiekhaee, M.R.; Qi, G.; Iizuka, S.; Ogawa, I.; Campisi, G.; Lo Muzio, L.; Abiko, Y.; Kikuchi, A.; Takata, T.
MMP-10/stromelysin-2 promotes invasion of head and neck cancer
PLoS ONE
6
e25438
2011
Homo sapiens
Regala, R.; Justilien, V.; Walsh, M.; Weems, C.; Khoor, A.; Murray, N.; Fields, A.
Matrix metalloproteinase-10 promotes Kras-mediated bronchio-alveolar stem cell expansion and lung cancer formation
PLoS ONE
6
e26439
2011
Mus musculus
Liu, H.; Qin, Y.; Bi, J.; Guo, A.; Fu, L.; Guan, X.
Overexpression of matrix metalloproteinase 10 is associated with poor survival in patients with early stage of esophageal squamous cell carcinoma
Dis. Esophagus
25
656-663
2012
Homo sapiens
Batra, J.; Robinson, J.; Soares, A.; Fields, A.; Radisky, D.; Radisky, E.
Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: Binding studies and crystal structure
J. Biol. Chem.
287
15935-15946
2012
Homo sapiens (P01033), Homo sapiens
Schlage, P.; Egli, F.; Nanni, P.; Wang, L.; Kizhakkedathu, J.; Apte, S.; Keller, U.
Time-resolved analysis of the matrix metalloproteinase 10 substrate degradome
Mol. Cell. Proteomics
13
580-593
2014
Mus musculus (O55123), Mus musculus BALB/c (O55123)
Justilien, V.; Regala, R.; Tseng, I.; Walsh, M.; Batra, J.; Radisky, E.; Murray, N.; Fields, A.
Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential
PLoS ONE
7
e35040
2012
Mus musculus (O55123), Mus musculus, Mus musculus C57BL/6 (O55123)
Batra, J.; Soares, A.; Mehner, C.; Radisky, E.
Matrix metalloproteinase-10/TIMP-2 structure and analyses define conserved core interactions and diverse exosite interactions in MMP/TIMP complexes
PLoS ONE
8
e75836
2013
Homo sapiens (P16035)
Avouac, J.; Guignabert, C.; Hoffmann-Vold, A.M.; Ruiz, B.; Dorfmuller, P.; Pezet, S.; Amar, O.; Tu, L.; Van Wassenhove, J.; Sadoine, J.; Launay, D.; Elhai, M.; Cauvet, A.; Subramaniam, A.; Resnick, R.; Hachulla, E.; Molberg, Oe.; Kahan, A.; Humbert, M.; Allanore, Y.
Role of stromelysin 2 (matrix metalloproteinase 10) as a novel mediator of vascular remodeling underlying pulmonary hypertension associated with systemic sclerosis
Arthritis Rheumatol.
69
2209-2221
2017
Mus musculus (O55123), Mus musculus, Homo sapiens (P09238), Homo sapiens
Kadeh, H.; Heydari, F.; Saravani, S.; Ghodsi, I.N.
Protein expression of stromelysin-2 in head and neck squamous cell carcinomas
Asian Pac. J. Cancer Prev.
16
7843-7846
2015
Homo sapiens
Vandivort, T.C.; Birkland, T.P.; Domiciano, T.P.; Mitra, S.; Kavanagh, T.J.; Parks, W.C.
Stromelysin-2 (MMP-10) facilitates clearance and moderates inflammation and cell death following lung exposure to long multiwalled carbon nanotubes
Int. J. Nanomedicine
12
1019-1031
2017
Mus musculus
McMahan, R.S.; Birkland, T.P.; Smigiel, K.S.; Vandivort, T.C.; Rohani, M.G.; Manicone, A.M.; McGuire, J.K.; Gharib, S.A.; Parks, W.C.
Stromelysin-2 (MMP10) moderates inflammation by controlling macrophage activation
J. Immunol.
197
899-909
2016
Mus musculus (O55123), Mus musculus, Mus musculus C57BL/6J (O55123)
Mirastschijski, U.; Dinesh, N.; Baskaran, S.; Wedekind, D.; Gavrilovic, J.; Murray, M.Y.; Bevan, D.; Kelm, S.
Novel specific human and mouse stromelysin-1 (MMP-3) and stromelysin-2 (MMP-10) antibodies for biochemical and immunohistochemical analyses
Wound Repair Regen.
27
309-323
2019
Mus musculus (O55123), Mus musculus, Mus musculus C57BL/KsOlaHsd-Db/+ (O55123)
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